Jacob McPhail
Scientist at StressMarq Biosciences Inc.- Claim this Profile
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Bio
Experience
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StressMarq Biosciences Inc.
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Canada
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Biotechnology Research
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1 - 100 Employee
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Scientist
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May 2020 - Present
Currently investigating the abnormal aggregation of key proteins driving neurodegenerative disease and developing these oligomeric proteins for use in Alzheimer's and Parkinson's drug discovery. Currently investigating the abnormal aggregation of key proteins driving neurodegenerative disease and developing these oligomeric proteins for use in Alzheimer's and Parkinson's drug discovery.
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University of Victoria
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Canada
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Higher Education
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700 & Above Employee
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PhD, Biochemistry
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Sep 2015 - May 2020
I studied the lipid kinase PI4KB to elucidate its key roles in the replication of several prominent human pathogens, including RNA viruses, malaria and cryptosporidium. I utilized numerous structural and biophysical techniques, including hydrogen-deuterium exchange mass spectrometry (HDX-MS), to study PI4KB and its crucial regulatory proteins at the molecular level. I also studied several novel inhibitors of PI4KB and the related PI3Ks using X-ray crystallography and kinase assays to aid in anti-viral, anti-malarial, and anti-cancer drug development. Show less
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Medicines for Malaria Venture
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Switzerland
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Non-profit Organizations
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100 - 200 Employee
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Research Collaborator
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Sep 2015 - May 2020
As part of an international collaboration focusing on drug development against the malaria parasite, I screened novel anti-malarial compounds for inhibition of a malaria kinase (PI4K) using lipid kinase activity assays on biochemically reconstituted membranes in the Dr. John Burke Laboratory. As part of an international collaboration focusing on drug development against the malaria parasite, I screened novel anti-malarial compounds for inhibition of a malaria kinase (PI4K) using lipid kinase activity assays on biochemically reconstituted membranes in the Dr. John Burke Laboratory.
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Wize
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United Kingdom
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Newspaper Publishing
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Instructor
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Sep 2018 - Apr 2020
I developed and instructed online final exam prep courses for 1st year Biology at UVic (BIOL184 and BIOL186) for over 1000+ students. I developed and instructed online final exam prep courses for 1st year Biology at UVic (BIOL184 and BIOL186) for over 1000+ students.
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Instructor
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Sep 2016 - Sep 2019
I developed and instructed in-person final exam prep courses for 1st year Biology at UVic (BIOL184 and BIOL186) for class sizes ranging from 70-200+ students. I developed and instructed in-person final exam prep courses for 1st year Biology at UVic (BIOL184 and BIOL186) for class sizes ranging from 70-200+ students.
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Public Health Agency of Canada | Agence de la santé publique du Canada
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Government Administration
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700 & Above Employee
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Bacteriology Technician (Co-op)
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Sep 2013 - Dec 2013
I cloned, expressed and purified a Shiga toxin mutant from enterohemorrhagic E.coli 0157:H7 for utilization as a safe, non-toxic antigen for immunological experiments. I cloned, expressed and purified a Shiga toxin mutant from enterohemorrhagic E.coli 0157:H7 for utilization as a safe, non-toxic antigen for immunological experiments.
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Canadian Food Inspection Agency
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Canada
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Government Administration
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700 & Above Employee
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Virology Technician (Co-op)
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May 2013 - Aug 2013
I screened Canadian crops for infection with Plum Pox virus using ELISA and RT-qPCR, and also studied virions using transmission electron microscopy (TEM). I screened Canadian crops for infection with Plum Pox virus using ELISA and RT-qPCR, and also studied virions using transmission electron microscopy (TEM).
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Research Technician (Co-op)
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Jan 2013 - Apr 2013
I optimized the plaque reduction neutralization test (PRNT) for measles virus for use in a national measles immunity survey. I optimized the plaque reduction neutralization test (PRNT) for measles virus for use in a national measles immunity survey.
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Education
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University of Victoria
Doctor of Philosophy - PhD, Biochemistry -
University of Victoria
Bachelor of Science (Honours) with Co-op, Microbiology