Isabel Kurth
Vice President, Research at Inspirna, Inc. (formerly known as Rgenix, Inc.)- Claim this Profile
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Bio
Experience
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Vice President, Research
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Feb 2013 - Present
- Pre-clinical development strategy for oncology drug portfolio - Leading pre-clinical research and biomarker activities for small molecule and therapeutic antibody drug candidates - Supervising study teams to characterize MOA, evaluate in vitro and in vivo efficacy and assess translational biomarkers - Pre-clinical development strategy for oncology drug portfolio - Leading pre-clinical research and biomarker activities for small molecule and therapeutic antibody drug candidates - Supervising study teams to characterize MOA, evaluate in vitro and in vivo efficacy and assess translational biomarkers
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Rockefeller University
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United States
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Medical Practices
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1 - 100 Employee
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Post-doctoral Associate
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2007 - 2012
Developed a novel method to monitor lagging strand DNA synthesis. Investigated replisome function and revealed the mechanisms of lagging strand polymerase release.
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Director of Communication, Postdoctoral Association
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Aug 2008 - Jul 2011
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Columbia University
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United States
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Higher Education
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700 & Above Employee
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Post-doctoral Research Fellow
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Jan 2006 - Apr 2007
Established a cell-free system from Xenopus egg extracts to study telomere replication and telomere-mediated DNA damage response. Demonstrated the presence of functional origins within telomeric DNA. Characterized the DNA damage response of telomeric DNA in cell-free extract systems. Established a cell-free system from Xenopus egg extracts to study telomere replication and telomere-mediated DNA damage response. Demonstrated the presence of functional origins within telomeric DNA. Characterized the DNA damage response of telomeric DNA in cell-free extract systems.
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ISREC
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Research Services
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1 - 100 Employee
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Post-doctoral Research Associate
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Jun 2005 - Nov 2005
Characterized effects of telomerase RNA mutants on telomerase activity.
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Graduate Student
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Apr 2001 - Jun 2005
Biochemical analysis of human telomerase. Implemented and improved protein expression, reconstitution and purification of recombinant human telomerase. Characterized effects of telomerase RNA mutants on telomerase activity.Analyzed the regulation of telomerase activity by hPot1.
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Education
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ISREC/ University of Lausanne
PhD, Biochemistry -
University of Bern
M. Sc., Chemistry