Experience

Iambic Therapeutics

• United States
• Biotechnology Research
• 1 - 100 Employee

• Principal Scientist

  • Oct 2021 - Present



Metacrine, Inc.

• United States
• Biotechnology Research
• 1 - 100 Employee

• Research Scientist II

  • Aug 2021 - Oct 2021

• Research Scientist I

  • Apr 2019 - Aug 2021



Gossamer Bio

• United States
• Biotechnology Research
• 100 - 200 Employee

• Research Scientist

  • May 2018 - Apr 2019



Dart NeuroScience

• Greater San Diego Area

• Senior Associate Scientist

  • Oct 2011 - Feb 2018

  • Designed and advanced a lead compound from a library hit to pre-clinical candidate status. • Synthesized more than one thousand novel compounds to optimize the ADME and pharmacokinetics properties. • Optimized synthetic routes to prepare advanced intermediates to explore SAR of promising cores more efficiently through the library approach. • Independently designed and proposed new compound targets based on structure activity relationship and ADME data. • Demonstrated expertise in… Show more • Designed and advanced a lead compound from a library hit to pre-clinical candidate status. • Synthesized more than one thousand novel compounds to optimize the ADME and pharmacokinetics properties. • Optimized synthetic routes to prepare advanced intermediates to explore SAR of promising cores more efficiently through the library approach. • Independently designed and proposed new compound targets based on structure activity relationship and ADME data. • Demonstrated expertise in the targeting of challenging CNS targets. • Delivered gram quantities of advanced compounds on time for various in-vivo and in-vitro studies. • Regular presentation and discussion of synthesis, SAR and DMPK results within multidisciplinary meetings. Show less • Designed and advanced a lead compound from a library hit to pre-clinical candidate status. • Synthesized more than one thousand novel compounds to optimize the ADME and pharmacokinetics properties. • Optimized synthetic routes to prepare advanced intermediates to explore SAR of promising cores more efficiently through the library approach. • Independently designed and proposed new compound targets based on structure activity relationship and ADME data. • Demonstrated expertise in… Show more • Designed and advanced a lead compound from a library hit to pre-clinical candidate status. • Synthesized more than one thousand novel compounds to optimize the ADME and pharmacokinetics properties. • Optimized synthetic routes to prepare advanced intermediates to explore SAR of promising cores more efficiently through the library approach. • Independently designed and proposed new compound targets based on structure activity relationship and ADME data. • Demonstrated expertise in the targeting of challenging CNS targets. • Delivered gram quantities of advanced compounds on time for various in-vivo and in-vitro studies. • Regular presentation and discussion of synthesis, SAR and DMPK results within multidisciplinary meetings. Show less



Pfizer

• United States
• Pharmaceutical Manufacturing
• 700 & Above Employee

• Senior Scientist

  • Sep 2003 - Aug 2011

  • Contributed to many projects in different therapeutic areas, including Diabetes, Ophthalmology and Oncology. • Designed, synthesized and purified compounds as well as interpretation of appropriate analytical data (NMR, LC/MS, EA, HPLC). • Optimization of key reactions. • Delivered compounds on time for in vivo studies which involved multistep (>10) synthesis. • Utilized structure activity relationship, HTS hits, and medicinal chemistry principles to design synthetic targets… Show more • Contributed to many projects in different therapeutic areas, including Diabetes, Ophthalmology and Oncology. • Designed, synthesized and purified compounds as well as interpretation of appropriate analytical data (NMR, LC/MS, EA, HPLC). • Optimization of key reactions. • Delivered compounds on time for in vivo studies which involved multistep (>10) synthesis. • Utilized structure activity relationship, HTS hits, and medicinal chemistry principles to design synthetic targets for lead discovery. • Optimization of structures to address issues of target potency, selectivity, and animal pharmacokinetics. • Utilized PMC approach, and the microwave reactor to increase productivity and to explore the SAR of a series in a timely manner. • Optimized and screened palladium-catalyzed coupling reactions to enable library production. • Managed outsourced projects through proposing viable synthetic routes, and keeping the project team updated with the progress of the outsourced packets frequently. • Contributed to patent applications through preparation of the experimental details and interpretation of analytical data. • Communication of chemistry progress to the project team through regular presentations in meetings and contributing to the monthly report. • Participated in ISO/OHSAS audit interview to ensure safe and clean environment at the work place. Show less • Contributed to many projects in different therapeutic areas, including Diabetes, Ophthalmology and Oncology. • Designed, synthesized and purified compounds as well as interpretation of appropriate analytical data (NMR, LC/MS, EA, HPLC). • Optimization of key reactions. • Delivered compounds on time for in vivo studies which involved multistep (>10) synthesis. • Utilized structure activity relationship, HTS hits, and medicinal chemistry principles to design synthetic targets… Show more • Contributed to many projects in different therapeutic areas, including Diabetes, Ophthalmology and Oncology. • Designed, synthesized and purified compounds as well as interpretation of appropriate analytical data (NMR, LC/MS, EA, HPLC). • Optimization of key reactions. • Delivered compounds on time for in vivo studies which involved multistep (>10) synthesis. • Utilized structure activity relationship, HTS hits, and medicinal chemistry principles to design synthetic targets for lead discovery. • Optimization of structures to address issues of target potency, selectivity, and animal pharmacokinetics. • Utilized PMC approach, and the microwave reactor to increase productivity and to explore the SAR of a series in a timely manner. • Optimized and screened palladium-catalyzed coupling reactions to enable library production. • Managed outsourced projects through proposing viable synthetic routes, and keeping the project team updated with the progress of the outsourced packets frequently. • Contributed to patent applications through preparation of the experimental details and interpretation of analytical data. • Communication of chemistry progress to the project team through regular presentations in meetings and contributing to the monthly report. • Participated in ISO/OHSAS audit interview to ensure safe and clean environment at the work place. Show less



SUGEN

• Research Associate

  • Jan 2000 - Sep 2003

  • Contributed to multiple kinase projects including c-Met as a key team player through synthesis, purification, and characterization of novel chemical entities. • Investigated reaction routes for construction of patented, novel c-Met kinase inhibitors. • Designed synthetic routes and executed the synthesis of analogs for lead optimization. • Purified final compounds through flash chromatography, preparative HPLC or crystallization. • Characterized final compounds, using HPLC, NMR… Show more • Contributed to multiple kinase projects including c-Met as a key team player through synthesis, purification, and characterization of novel chemical entities. • Investigated reaction routes for construction of patented, novel c-Met kinase inhibitors. • Designed synthetic routes and executed the synthesis of analogs for lead optimization. • Purified final compounds through flash chromatography, preparative HPLC or crystallization. • Characterized final compounds, using HPLC, NMR, and LC/MS for purity, before submitting for biochemical screening. • Contributed over 300 compounds to support the medicinal chemistry effort in different projects. Show less • Contributed to multiple kinase projects including c-Met as a key team player through synthesis, purification, and characterization of novel chemical entities. • Investigated reaction routes for construction of patented, novel c-Met kinase inhibitors. • Designed synthetic routes and executed the synthesis of analogs for lead optimization. • Purified final compounds through flash chromatography, preparative HPLC or crystallization. • Characterized final compounds, using HPLC, NMR… Show more • Contributed to multiple kinase projects including c-Met as a key team player through synthesis, purification, and characterization of novel chemical entities. • Investigated reaction routes for construction of patented, novel c-Met kinase inhibitors. • Designed synthetic routes and executed the synthesis of analogs for lead optimization. • Purified final compounds through flash chromatography, preparative HPLC or crystallization. • Characterized final compounds, using HPLC, NMR, and LC/MS for purity, before submitting for biochemical screening. • Contributed over 300 compounds to support the medicinal chemistry effort in different projects. Show less