Experience

Nvelop Therapeutics

• United States
• Biotechnology Research
• 1 - 100 Employee

• Senior Scientist

  • Apr 2023 - Present



Oncorus

• United States
• Biotechnology Research
• 1 - 100 Employee

• Scientist

  • Jan 2020 - Mar 2023

  •ONCR-021 (CVA21-LNP): -Designed and optimized new ribozymes and leaders to achieve maximum linealized ONCR-021 RNA during manufacturing. -Developed in-vitro assays to quickly assess kickoff and screen different ONCR-021 ribozymes and leaders. -Validated receptor necessity and sufficiency of ONCR-021 in human cancer cell lines. -Determined cross-species specificity of ONCR-021 viral entry receptor. -Characterized ONCR-021 viral genomic drift rate (replication fidelity). -Characterized ONCR-021 RdRp recombination rate. •ONCR-GBM (EGFR-targeted HSV1): -Demonstrated ONCR-GBM entry receptor targeting from Nectin-1 only to EGFR and Nectin-1 -Validated ONCR-GBM EGFR receptor necessity and sufficiency in human GBM cell lines. •New Discovery candidates (vRNA-LNP): -Developed and validated 3 novel oncolytic synthetic viruses as candidates for our IV self-amplifying vRNA-LNP platform. -Optimized IVT RNA template to completely remove abortive IVT RNA production. -Optimized IVT RNA capping for maximal kickoff and suitability for large scale LNP-RNA encapsidation. -Optimized the design, production and purification of numerous viral vectors and lentivirus vectors (LVV). -Armed the new viruses with therapeutic immunostimulatory payloads and optimized payload production to higher levels than for our other platforms. -Experience with creation and optimization of chimeric RNA viruses with different entry receptor tropisms. -Implemented a stable IRES-dependent strategy to limit possible community transmission of our new candidates. -Performed in-vitro selection of best indications and syngeneic lines for future candidate development. -Mentored and trained numerous co-ops, students and lab personnel. Show less



University of Rochester Medical Center

• United States
• Hospitals and Health Care
• 700 & Above Employee

• Graduate Researcher

  • Jul 2014 - Nov 2019

  - Developed novel techniques to quantify metabolic fluxes. - Utilized targeted LC-MS and other metabolic assays to quantify HCMV-induced changes in metabolic fluxes and steady state metabolite concentrations. - Generated novel HCMV recombinant viruses by BAC-recombineering. - Developed protocols to generate and genotype CRISPR/Cas9 knock-out primary human cell lines. - Collaborated in three additional projects: - Developed new genetic tools to improve in vitro and in vivo study of Influenza A and B viruses. - Tested new drugs for anti-retroviral use to fight HIV-1 infection and latency. - Studied the mechanisms behind Frog virus 3 viral pathogenesis and immunity in Xenopus laevis. Show less



CNIC - Spanish National Center for Cardiovascular Research / Centro Nac. Investigaciones Cardiovasc.

• Spain
• Research Services
• 400 - 500 Employee

• Researcher

  • Sep 2013 - Sep 2013

  - Investigated the use of attenuated vaccinia viruses as vaccine vectors. - Investigated the use of attenuated vaccinia viruses as vaccine vectors.



Drexel University College of Medicine

• United States
• Higher Education
• 700 & Above Employee

• Researcher

  • Jun 2012 - Oct 2012

  - Studied the binding site interactions of peptide triazole inactivators of HIV-1 with the glycoprotein gp120. - Studied the binding site interactions of peptide triazole inactivators of HIV-1 with the glycoprotein gp120.



Amigó Foundation

• Madrid y alrededores, España

• Volunteer

  • Sep 2009 - Jun 2010

  Tutored students from underprivileged families. Tutored students from underprivileged families.



Universidad Francisco de Vitoria

• Spain
• Higher Education
• 700 & Above Employee

• Laboratory assistantship

  • Sep 2008 - Jun 2009

  Laboratory assistantship in a Prostate Cancer Research group studying genetic expression in prostate cancer with an emphasis on identifying and characterizing the key molecules participating in the development and progression of the disease. Laboratory assistantship in a Prostate Cancer Research group studying genetic expression in prostate cancer with an emphasis on identifying and characterizing the key molecules participating in the development and progression of the disease.