Experience

University of Texas Southwestern Medical Center

• United States
• Higher Education
• 400 - 500 Employee

• Postdoctoral Researcher

  • Dec 2022 - Present

  Dallas, Texas, United States Understand cell migration/invasion of normal epithelial and carcinoma cells with specific focus on the cell-autonomous metabolic and plasticity requirements



Kansas State University

• United States
• Higher Education
• 700 & Above Employee

• Postdoctoral Researcher

  • Sep 2021 - Nov 2022

  Manhattan, Kansas, United States Project 1: Targeting tumor cell-specific ADAM proteases to improve anti-tumor immunity in mouse models of triple-negative breast cancer (TNBC) Project 2: Establish a mechanistic link between mutations in the human CLPB gene and congenital neutropenia



Kansas State University

• United States
• Higher Education
• 700 & Above Employee

• Graduate Research And Teaching Assistant

  • Jan 2016 - Dec 2020

  Manhattan, Kansas, United States Project 1: STRUCTURAL AND FUNCTIONAL CONSEQUENCES OF THE CANCER-LINKED MUTATIONS IN THE TRANSACTIVATION DOMAIN (TAD) OF P53 My research focused on understanding how the cancer-linked mutations in the N-terminal transactivation domain of p53 could perturb the balance between the binding of p53 to Human-Double-minute-2 (HDM2) and CREB-binding protein (CBP). By combining experimental and computational approaches, we assessed the conformational ensemble changes in p53 TAD resulting from… Show more Project 1: STRUCTURAL AND FUNCTIONAL CONSEQUENCES OF THE CANCER-LINKED MUTATIONS IN THE TRANSACTIVATION DOMAIN (TAD) OF P53 My research focused on understanding how the cancer-linked mutations in the N-terminal transactivation domain of p53 could perturb the balance between the binding of p53 to Human-Double-minute-2 (HDM2) and CREB-binding protein (CBP). By combining experimental and computational approaches, we assessed the conformational ensemble changes in p53 TAD resulting from the cancer-linked mutations. (NMR and Molecular simulation approaches were incorporated by collaborations) Project 2: SKD3/HUMAN CLPB, AN AAA+ ATPASE LINKED TO MULTIPLE PATHOLOGIES: CELLULAR LOCALIZATION AND PROCESSING SKD3, also known as mammalian ClpB, belongs to the AAA+ family of ATPases associated with different activities. The actual function of SKD3 is unknown. Mutations in the skd3/hclpB gene have been linked to various pathologies with a broad phenotypic spectrum, including 3-methylglutaconic aciduria, cataract, intellectual disability/developmental delay, congenital neutropenia, progressive brain atrophy, and movement disorder. The clinical manifestations of the mutations are currently impossible to explain due to the lack of understanding of the biological function of SKD3. Our goal of this project was to search for interacting partners and substrates of SKD3/hClpB and investigate how the ATP-dependent function of SKD3/hClpB supports the mitochondrial biogenesis, metabolism and/or proteostasis. Show less



University of Colombo

• Sri Lanka
• Higher Education
• 700 & Above Employee

• Teaching Assistant

  • Aug 2014 - Feb 2015

  Colombo, Western, Sri Lanka - Conducted laboratory courses for Molecular Biology and Biochemistry undergraduate students. - Coordinated and evaluated experimental laboratory sessions in Chemistry and Biochemistry for undergraduate students. - Conducted and evaluated tutorials for undergraduate students.



Nawaloka Molecular Biology and Genetics Laboratory

• Trainee Scientific Officer

  • Jul 2014 - Jul 2014

  Hands on experience on the following tests using real time PCR. 1) MTB and NTM Diagnosis Test 2) Nucleic acid Test (HIV, HBV and HCV test) 3) JAK2 Mutation Detection Test