Experience

Antler Bio Ltd

• Ireland
• Biotechnology
• 1 - 100 Employee

• Head Of Research And Development

  • Nov 2021 - Present

  England, United Kingdom



Imperial College London

• Research Services
• 700 & Above Employee

• Postdoctoral Research Associate

  • Feb 2019 - Nov 2021

  Hammersmith Hospital I investigate mechanisms of a novel dual methyl transferase inhibitor on the epigenomic landscape, biomarkers of drug resistance and PARP synergy in ovarian cancer cell lines. I have developed and supervised analysis of integrating G4-seq data with the ATAC-seq data I generated and a novel bioinformatics approach to identify motifs within accessible regions in super-enhancers.

• Research Associate in Epigenetics and Bioinformatics

  • May 2016 - Feb 2019

  Hammersmith hospital I researched the role of epigenetics in pancreatic cancer using a combination of wet-lab and and bioinformatic analyses. I used R/Python/bash/Unix to generate scripts and packages including, bedtools, samtools, ggplot2, ChIPseeker, ROSE, homer and Limma. I generated/analysed multiple pancreatic cancer cell line ATAC/ChIP-seq libraries and drug screens. Using an integrative analysis approach I identified potential responders to a given drug based on their genomic/epigenomic profiles. Part of… Show more I researched the role of epigenetics in pancreatic cancer using a combination of wet-lab and and bioinformatic analyses. I used R/Python/bash/Unix to generate scripts and packages including, bedtools, samtools, ggplot2, ChIPseeker, ROSE, homer and Limma. I generated/analysed multiple pancreatic cancer cell line ATAC/ChIP-seq libraries and drug screens. Using an integrative analysis approach I identified potential responders to a given drug based on their genomic/epigenomic profiles. Part of this work has been published in Cell (Reports) with a first-author paper in writing.



University of Nottingham

• United Kingdom
• Research Services
• 700 & Above Employee

• Researcher

  • Sep 2010 - Jul 2011

  Nottingham, United Kingdom Analysing the potential use of a multiple-protein based microarray which can simultaneously profile four different immunoglobulin classes, for use in canine allergy diagnostics.