I-Chiao Lee
Postdoctoral Researcher at Wageningen Bioveterinary Research- Claim this Profile
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Bio
Experience
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Wageningen Bioveterinary Research
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Netherlands
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Research Services
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100 - 200 Employee
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Postdoctoral Researcher
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Jul 2017 - Present
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Wageningen University & Research
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Netherlands
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Research Services
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700 & Above Employee
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AIO
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Apr 2011 - Mar 2016
This PhD research focuses on the molecular analysis of potential probiotic effector molecules of Lactobacillus plantarum. Throughout the studies of probiotic activity, it became apparent that the probiotic effects are often species and/or strain specific. This thesis focuses on potential cell envelope effector molecules involved in interaction with the mammalian host cells, including lipoteichoic acid (LTA), lipo- and glyco-proteins, and extracellular polysaccharides (EPS), of L. plantarum WCFS1. Her research showed that surface molecules not only play important roles in bacterial physiology, but also in the interaction with the host mucosa through pattern recognition receptors expressed by the host cells. With the growing amount of evidence of structural variations in surface molecules, which are influenced by genetic background, physiological status, environmental factors, and other biological processes, these molecules form a unique signature associated with each strain that as a consequence elicits a strain-specific response when interacting with host cells. Show less
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Internship
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Apr 2010 - Aug 2010
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Education
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Wageningen University
MSc, Biotechnology