Hsiu-Wen (Irene) Tsai
Director, Histology at Champions Oncology, Inc.- Claim this Profile
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Bio
Experience
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Champions Oncology, Inc.
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United States
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Biotechnology
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100 - 200 Employee
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Director, Histology
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Dec 2021 - Present
United States
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Subject Matter Expert
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Mar 2021 - Dec 2021
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The Johns Hopkins University
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United States
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Higher Education
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700 & Above Employee
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Research Fellow
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Aug 2018 - Mar 2021
Baltimore, Maryland Area * Explore immunologic and metabolic mechanisms promoting laryngotracheal inflammation, airway wall remodeling, and fibrosis to develop new therapeutic strategies for airway diseases. * Collect fibrosis scar from patients with iatrogenic laryngotracheal stenosis to analyze the cell subtypes by means of flow cytometry and single-cell RNA seq analysis. * Obtain fibrosis samples from patients with iatrogenic laryngotracheal stenosis to develop primary cell culture (fibroblasts and… Show more * Explore immunologic and metabolic mechanisms promoting laryngotracheal inflammation, airway wall remodeling, and fibrosis to develop new therapeutic strategies for airway diseases. * Collect fibrosis scar from patients with iatrogenic laryngotracheal stenosis to analyze the cell subtypes by means of flow cytometry and single-cell RNA seq analysis. * Obtain fibrosis samples from patients with iatrogenic laryngotracheal stenosis to develop primary cell culture (fibroblasts and epithelial cells) for in vitro assay. * Focus on airway epithelial stem cell differentiation and function test, including trans-membrane electrical resistance measurement, permeability test, and interactions with fibroblasts. Show less
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University of Florida
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United States
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Higher Education
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700 & Above Employee
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Postdoctoral Fellow
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May 2013 - Apr 2017
Gainesville, Florida Area * Set up multi-channel electrode arrays to record neurons in the brainstem of small animals to map the interconnections of respiratory-related neurons during a swallow, airway obstruction, and breathing. * Assisted with the development of an internal airway percussion medical device to increase the concentration of exhaled protein in humans and canines for the future diagnosis of pulmonary diseases. * Collaborated with a clinical physician for the measurement of cough ability in… Show more * Set up multi-channel electrode arrays to record neurons in the brainstem of small animals to map the interconnections of respiratory-related neurons during a swallow, airway obstruction, and breathing. * Assisted with the development of an internal airway percussion medical device to increase the concentration of exhaled protein in humans and canines for the future diagnosis of pulmonary diseases. * Collaborated with a clinical physician for the measurement of cough ability in elderly patients with non-tuberculous mycobacteria (NTM) infections. Demonstrated patients with NTM had defect cough ability that might cause lung infections.
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Graduate Research Assistant
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Aug 2008 - May 2013
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Staff Scientist
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Oct 2007 - Jul 2008
Hsinchu City, Taiwan * Developed and tested the safety and purity of new drugs for the treatment of cough. * Followed the USP to test the drug’s purity and stability. Analyzed the data and summarized the data for quality control.
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National Taiwan University Hospital
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Taiwan
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Medical Practices
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300 - 400 Employee
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Research Assistant
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Dec 2004 - Sep 2007
* Demonstrated transient limb ischemia and simvastatin increase the expression of heme-oxygenase-1 to protect the liver from ischemia-reperfusion injury
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Education
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University of Florida
Doctor of Philosophy - PhD, Physiological Sciences -
National Cheng Kung University
Master's degree, Biochemistry, Biophysics and Molecular Biology