Hope Flaxman
Research Scientist, Proteomics & UPS Biology at C4 Therapeutics, Inc.- Claim this Profile
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Bio
Experience
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C4 Therapeutics, Inc.
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United States
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Biotechnology
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1 - 100 Employee
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Research Scientist, Proteomics & UPS Biology
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Jan 2022 - Present
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Harvard University
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United States
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Higher Education
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700 & Above Employee
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Graduate Researcher
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2016 - Dec 2021
Structural and mechanistic studies of molecular glues and their targets, advised by Professor Christina Woo - Studied photo-rapamycin as a model system for gaining structural insight into ternary complexes using photo-affinity labeling proteomics - Optimized small molecule interactome mapping by photo-affinity labeling (SIM-PAL) method - Identified cyclophilin B as a major target of the natural product sanglifehrin A using photo-affinity labeling proteomics and collaborated with the Lagares’ lab (Massachusetts General Hospital) to demonstrate application of sanglifehrin A in fibrosis in cellular and mouse models - Revealed cyclic imides on protein C-termini as degrons for the immunomodulatory drug target cereblon utilizing targeted protein degradation and protein semi-synthesis - Collaborated with lab members with specialties including synthetic chemistry and bioinformatics, core facility staff, and labs at other institutions - Mentored 5 rotation students and 3 undergraduates - Assisted in instruction of organic chemistry (undergraduate, lab) and chemical biology (graduate, section) as a teaching fellow Show less
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Massachusetts Institute of Technology
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United States
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Higher Education
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700 & Above Employee
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Undergraduate Researcher
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Jan 2014 - May 2016
Investigation of the metal-binding protein S100A15, advised by Professor Elizabeth Nolan - Developed methods to overexpress and purify S100A15 and characterized its activity via metal-binding titrations and anti-microbial assays Investigation of the metal-binding protein S100A15, advised by Professor Elizabeth Nolan - Developed methods to overexpress and purify S100A15 and characterized its activity via metal-binding titrations and anti-microbial assays
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Precision Economics, LLC
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United States
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Financial Services
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1 - 100 Employee
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Intern
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May 2013 - Aug 2013
Assisted in the preparation of economics expert witness reports for valuation disputes Assisted in the preparation of economics expert witness reports for valuation disputes
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Massachusetts Institute of Technology
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United States
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Higher Education
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700 & Above Employee
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UROP in Applied Mathematics
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Feb 2013 - May 2013
Improved algorithms for data processing of biofluid dynamics in MATLAB Improved algorithms for data processing of biofluid dynamics in MATLAB
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MITRE
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United States
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IT Services and IT Consulting
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700 & Above Employee
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Intern
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Jan 2013 - Jan 2013
Developed computer vision programs in MATLAB Developed computer vision programs in MATLAB
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Fairfax County Public Schools
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United States
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Primary and Secondary Education
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700 & Above Employee
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Summer Chemistry Laboratory and Teaching Assistant, TJHSST
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Jul 2012 - Aug 2012
Assisted in teaching introductory high school chemistry to students in accelerated summer program Assisted in teaching introductory high school chemistry to students in accelerated summer program
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Naval Surface Warfare Center, Carderock Division, U.S.Navy
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Armed Forces
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200 - 300 Employee
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SEAP Intern in Battery Technology Group
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Jun 2011 - Aug 2011
Aided engineers in performing battery safety tests and developed model of battery heating and cooling during charge and discharge Aided engineers in performing battery safety tests and developed model of battery heating and cooling during charge and discharge
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Education
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Harvard University
Doctor of Philosophy (Ph.D.), Chemistry and Chemical Biology -
MIT
Bachelor's Degree, Chemistry and Biology