Hongyu Zhang

Summer Intern at Roche Sequencing USA
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Contact Information
us****@****om
(386) 825-5501
Location
Los Angeles, California, United States, US

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Bio

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Credentials

  • Become a Financial Analyst
    LinkedIn
    Nov, 2022
    - Oct, 2024
  • Financial Accounting Foundations
    LinkedIn
    Oct, 2022
    - Oct, 2024
  • Strategic Planning Foundations
    LinkedIn
    Oct, 2022
    - Oct, 2024

Experience

    • United States
    • Biotechnology Research
    • 100 - 200 Employee
    • Summer Intern
      • May 2023 - Present

    • United States
    • Higher Education
    • 700 & Above Employee
    • Ph.D Candidate
      • Sep 2018 - Present

      -Constructed phage display libararywith llama VHH genome and performed bio-panning and screening for selection of antibodies that bind to Fatty acid amide hydrolase (FAAH). -Performed Affinity maturation on the selected antibodies and determined the affinity of the antibodies by ELISA and SPR assays.-Combined innovative molecular and computational biology techniques to understand the key enzyme, Activation-induced cytidine deaminase, in the affinity maturation process.-Constructed Illumina NGS library from single-strand DNA and optimized the protocol for identifying rare mutations created by the target enzyme. -Used Python to process and clean up the NGS sequencing data for analysis. Show less

    • Teaching Assistant
      • Jan 2021 - May 2021

      -Taught weekly lab sections to undergrad students. -Presentations aimed to help students understand the concepts of the weekly lab experiment.-Helped write and grade homework assignments and lab exams.

    • Switzerland
    • Venture Capital and Private Equity Principals
    • 1 - 100 Employee
    • Research Fellow
      • Feb 2022 - Jul 2022

      -Performed due diligence on startups weekly to evaluate the scientific validity and investment opportunities. -Sourced potential clients each week to help build deal flows. -Scouted at startups that could fit in Nodes’ Biotech X AI program. -Performed due diligence on startups weekly to evaluate the scientific validity and investment opportunities. -Sourced potential clients each week to help build deal flows. -Scouted at startups that could fit in Nodes’ Biotech X AI program.

    • United States
    • Non-profit Organizations
    • 1 - 100 Employee
    • Vice-director of Career Development
      • Jun 2020 - Dec 2020

      -Connected students to various career resources. -Initiated the connection between CGSA and USC resources (USC ALI and USC Career Center). -Started the collaboration between CGSA and multiple Recruiter companies including Boss Zhipin and Liepin. -Connected students to various career resources. -Initiated the connection between CGSA and USC resources (USC ALI and USC Career Center). -Started the collaboration between CGSA and multiple Recruiter companies including Boss Zhipin and Liepin.

    • United States
    • Higher Education
    • 700 & Above Employee
    • Research Assistant
      • Jun 2017 - Sep 2018

      -Produced lentivirus with shRNA and infected cholangiocarcinoma cancer cells to knock TET1 gene activity. -Performed cell counting, MTT assay, and colony formation assay to determine how TET1 gene can affect the survival of cancer cells. -Used western blot and qPCR experiments to find out the signal pathway of TET1 gene. -Grew and took care of transgenic mice. -Produced lentivirus with shRNA and infected cholangiocarcinoma cancer cells to knock TET1 gene activity. -Performed cell counting, MTT assay, and colony formation assay to determine how TET1 gene can affect the survival of cancer cells. -Used western blot and qPCR experiments to find out the signal pathway of TET1 gene. -Grew and took care of transgenic mice.

    • Research Assistant
      • Mar 2016 - Jul 2017

      -Brainstormed and designed a better way to treat Multiple Myeloma with patient-specific features, which is possible to be industrial mass production.-Conducted literature reviews and searched IMGT/LIGM database to find a possible targeting method for the Myeloma cell with better accuracy.-Generated a library of amino acid sequences which could be the potential treatment targets

    • Research Assistant
      • Mar 2016 - Jul 2017

      -Determined the level and quantity of pancreatic trypsin leakage by immunohistochemistry of intestinal sections after hemorrhagic shock.-Studied two forms of protease inhibitions, single enteral inhibition with doxycycline (a MMPs inhibitor) without and with enteral serine protease inhibition, analyzed the results using ImageJ.-Concluded that the irreversible opening of the mucosal barrier in hemorrhagic shock involves multiple proteases and a dual inhibition serves to minimize the leakage of digestive enzymes out of the lumen of the small intestine.-Explored the influence of aging and diet on digestive enzyme leakage in brain tissues. Show less

Education

  • University of Southern California
    Doctor of Philosophy - PhD, Molecular Biology
    2018 - 2023
  • University of California, San Diego
    Bachelor's degree, Biomedical/Medical Engineering
    2013 - 2017
  • Andrews Osborne Academy
    High School Diploma
    2010 - 2013

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