Hongyu Zhang
Summer Intern at Roche Sequencing USA- Claim this Profile
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Bio
Credentials
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Become a Financial Analyst
LinkedInNov, 2022- Oct, 2024 -
Financial Accounting Foundations
LinkedInOct, 2022- Oct, 2024 -
Strategic Planning Foundations
LinkedInOct, 2022- Oct, 2024
Experience
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Roche Sequencing USA
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United States
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Biotechnology Research
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100 - 200 Employee
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Summer Intern
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May 2023 - Present
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University of Southern California
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United States
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Higher Education
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700 & Above Employee
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Ph.D Candidate
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Sep 2018 - Present
-Constructed phage display libararywith llama VHH genome and performed bio-panning and screening for selection of antibodies that bind to Fatty acid amide hydrolase (FAAH). -Performed Affinity maturation on the selected antibodies and determined the affinity of the antibodies by ELISA and SPR assays.-Combined innovative molecular and computational biology techniques to understand the key enzyme, Activation-induced cytidine deaminase, in the affinity maturation process.-Constructed Illumina NGS library from single-strand DNA and optimized the protocol for identifying rare mutations created by the target enzyme. -Used Python to process and clean up the NGS sequencing data for analysis. Show less
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Teaching Assistant
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Jan 2021 - May 2021
-Taught weekly lab sections to undergrad students. -Presentations aimed to help students understand the concepts of the weekly lab experiment.-Helped write and grade homework assignments and lab exams.
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Nodes Advisors AG
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Switzerland
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Venture Capital and Private Equity Principals
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1 - 100 Employee
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Research Fellow
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Feb 2022 - Jul 2022
-Performed due diligence on startups weekly to evaluate the scientific validity and investment opportunities. -Sourced potential clients each week to help build deal flows. -Scouted at startups that could fit in Nodes’ Biotech X AI program. -Performed due diligence on startups weekly to evaluate the scientific validity and investment opportunities. -Sourced potential clients each week to help build deal flows. -Scouted at startups that could fit in Nodes’ Biotech X AI program.
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USC CGSA
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United States
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Non-profit Organizations
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1 - 100 Employee
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Vice-director of Career Development
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Jun 2020 - Dec 2020
-Connected students to various career resources. -Initiated the connection between CGSA and USC resources (USC ALI and USC Career Center). -Started the collaboration between CGSA and multiple Recruiter companies including Boss Zhipin and Liepin. -Connected students to various career resources. -Initiated the connection between CGSA and USC resources (USC ALI and USC Career Center). -Started the collaboration between CGSA and multiple Recruiter companies including Boss Zhipin and Liepin.
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Brown University
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United States
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Higher Education
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700 & Above Employee
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Research Assistant
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Jun 2017 - Sep 2018
-Produced lentivirus with shRNA and infected cholangiocarcinoma cancer cells to knock TET1 gene activity. -Performed cell counting, MTT assay, and colony formation assay to determine how TET1 gene can affect the survival of cancer cells. -Used western blot and qPCR experiments to find out the signal pathway of TET1 gene. -Grew and took care of transgenic mice. -Produced lentivirus with shRNA and infected cholangiocarcinoma cancer cells to knock TET1 gene activity. -Performed cell counting, MTT assay, and colony formation assay to determine how TET1 gene can affect the survival of cancer cells. -Used western blot and qPCR experiments to find out the signal pathway of TET1 gene. -Grew and took care of transgenic mice.
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Research Assistant
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Mar 2016 - Jul 2017
-Brainstormed and designed a better way to treat Multiple Myeloma with patient-specific features, which is possible to be industrial mass production.-Conducted literature reviews and searched IMGT/LIGM database to find a possible targeting method for the Myeloma cell with better accuracy.-Generated a library of amino acid sequences which could be the potential treatment targets
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Research Assistant
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Mar 2016 - Jul 2017
-Determined the level and quantity of pancreatic trypsin leakage by immunohistochemistry of intestinal sections after hemorrhagic shock.-Studied two forms of protease inhibitions, single enteral inhibition with doxycycline (a MMPs inhibitor) without and with enteral serine protease inhibition, analyzed the results using ImageJ.-Concluded that the irreversible opening of the mucosal barrier in hemorrhagic shock involves multiple proteases and a dual inhibition serves to minimize the leakage of digestive enzymes out of the lumen of the small intestine.-Explored the influence of aging and diet on digestive enzyme leakage in brain tissues. Show less
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Education
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University of Southern California
Doctor of Philosophy - PhD, Molecular Biology -
University of California, San Diego
Bachelor's degree, Biomedical/Medical Engineering -
Andrews Osborne Academy
High School Diploma