Hongyao “Yao” Yu
Senior Scientist at SeQure Dx- Claim this Profile
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Bio
Credentials
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edX Honor Code Certificate for Introduction to Bioconductor
edXAug, 2015- Sep, 2024 -
edX Honor Code Certificate for Case Study: ChIP-seq data analysis
edXJun, 2015- Sep, 2024 -
edX Honor Code Certificate for Matrix Algebra and Linear Models
edXJun, 2015- Sep, 2024 -
edX Honor Code Certificate for Statistics and R for the Life Sciences
edXJun, 2015- Sep, 2024 -
Case study: ChIP-seq data analysis
edX
Experience
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SeQure Dx
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United States
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Biotechnology Research
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1 - 100 Employee
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Senior Scientist
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Sep 2022 - Present
Development and productization of multiple NGS based methods for ON/OFF target editing detection. Development and productization of multiple NGS based methods for ON/OFF target editing detection.
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Scientist
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May 2020 - Sep 2022
• Led several multi-institutional collaborations, including projects with the National Center for Advancing Translational Sciences, the NIH Intramural Sequencing Center, UNC-Chapel Hill, and NC State. Also managed several cross-divisional and internal collaborations, including projects with the NIEHS Division of National Toxicology Program and other NIEHS labs. • Developed two novel sequencing methods that can determine the length of Poly(A) tails with extremely low input. • Carried out… Show more • Led several multi-institutional collaborations, including projects with the National Center for Advancing Translational Sciences, the NIH Intramural Sequencing Center, UNC-Chapel Hill, and NC State. Also managed several cross-divisional and internal collaborations, including projects with the NIEHS Division of National Toxicology Program and other NIEHS labs. • Developed two novel sequencing methods that can determine the length of Poly(A) tails with extremely low input. • Carried out genome-wide screens in mouse and human embryonic stem cells with CRISPR/Cas9 and siRNA libraries. Show less • Led several multi-institutional collaborations, including projects with the National Center for Advancing Translational Sciences, the NIH Intramural Sequencing Center, UNC-Chapel Hill, and NC State. Also managed several cross-divisional and internal collaborations, including projects with the NIEHS Division of National Toxicology Program and other NIEHS labs. • Developed two novel sequencing methods that can determine the length of Poly(A) tails with extremely low input. • Carried out… Show more • Led several multi-institutional collaborations, including projects with the National Center for Advancing Translational Sciences, the NIH Intramural Sequencing Center, UNC-Chapel Hill, and NC State. Also managed several cross-divisional and internal collaborations, including projects with the NIEHS Division of National Toxicology Program and other NIEHS labs. • Developed two novel sequencing methods that can determine the length of Poly(A) tails with extremely low input. • Carried out genome-wide screens in mouse and human embryonic stem cells with CRISPR/Cas9 and siRNA libraries. Show less
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National Institute of Environmental Health Sciences (NIEHS)
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United States
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Research Services
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500 - 600 Employee
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Postdoctoral Fellowship
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Mar 2015 - Mar 2020
• Led multiple research projects, designed, and conducted experiments, analyzed and interpreted data, wrote manuscripts and had published 4 peer-reviewed articles, in one of which I was the co-correspondence author. • Performed numerous NGS based genomic approaches for my own projects and for collaborators. Carried-out data analyses using pipelines and command lines in LINUX or UNIX environments. • Generated ~20 cell lines of constitutive and conditional knock-outs, endogenous knock-ins… Show more • Led multiple research projects, designed, and conducted experiments, analyzed and interpreted data, wrote manuscripts and had published 4 peer-reviewed articles, in one of which I was the co-correspondence author. • Performed numerous NGS based genomic approaches for my own projects and for collaborators. Carried-out data analyses using pipelines and command lines in LINUX or UNIX environments. • Generated ~20 cell lines of constitutive and conditional knock-outs, endogenous knock-ins (tagging and reporters), and ATPase point mutations. • Designed and generated focused libraries of epigenetic regulators, and carried out screens by RNAi and CRISPR (activation and inhibition) by single cell screening approaches. Show less • Led multiple research projects, designed, and conducted experiments, analyzed and interpreted data, wrote manuscripts and had published 4 peer-reviewed articles, in one of which I was the co-correspondence author. • Performed numerous NGS based genomic approaches for my own projects and for collaborators. Carried-out data analyses using pipelines and command lines in LINUX or UNIX environments. • Generated ~20 cell lines of constitutive and conditional knock-outs, endogenous knock-ins… Show more • Led multiple research projects, designed, and conducted experiments, analyzed and interpreted data, wrote manuscripts and had published 4 peer-reviewed articles, in one of which I was the co-correspondence author. • Performed numerous NGS based genomic approaches for my own projects and for collaborators. Carried-out data analyses using pipelines and command lines in LINUX or UNIX environments. • Generated ~20 cell lines of constitutive and conditional knock-outs, endogenous knock-ins (tagging and reporters), and ATPase point mutations. • Designed and generated focused libraries of epigenetic regulators, and carried out screens by RNAi and CRISPR (activation and inhibition) by single cell screening approaches. Show less
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Shanghai Jiao Tong University
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China
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Higher Education
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700 & Above Employee
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Postdoctoral Fellow
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Dec 2012 - Jan 2015
• Led 4 projects and published 5 peer-reviewed articles, in 2 of which I was the first author and in one I was the co-correspondence author. • Led Group 'Stk40' and supervised graduates on project design, experimental conduction, data analyses, trouble shooting, and manuscript writing. • Led 4 projects and published 5 peer-reviewed articles, in 2 of which I was the first author and in one I was the co-correspondence author. • Led Group 'Stk40' and supervised graduates on project design, experimental conduction, data analyses, trouble shooting, and manuscript writing.
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Education
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2006 - 2012
Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences
Doctor of Philosophy - PhD, Stem Cell Biology -
2002 - 2006
Zhejiang University
Bachelor of Science - BS, Biotechnology
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