Experience

Quiver Bioscience

• United States
• Biotechnology Research
• 1 - 100 Employee

• Director, Pain Therapeutic Lead

  • Jan 2021 - Present

  Cambridge, Massachusetts, United States • Built Q-State internal program portfolios for pain; identified new opportunities and prepared target product profile (TPP); manage the timelines, budgets and resource allocations of 4 internal drug discovery pipeline projects in pain. • Led the efforts in several NIH SBIR grant applications; serve as the principal investigator for NIH SBIR Fast Track Grant that supports the development of anti-sense oligonucleotides (ASOs) as a therapeutic for chronic pain, $ 2.4 million grant awarded in… Show more • Built Q-State internal program portfolios for pain; identified new opportunities and prepared target product profile (TPP); manage the timelines, budgets and resource allocations of 4 internal drug discovery pipeline projects in pain. • Led the efforts in several NIH SBIR grant applications; serve as the principal investigator for NIH SBIR Fast Track Grant that supports the development of anti-sense oligonucleotides (ASOs) as a therapeutic for chronic pain, $ 2.4 million grant awarded in Sep 2020. • Supervise a team with research associates, engineers, and principal scientists. Lead regular team meetings and guide team members to solve projects issues, prioritize tasks and improve project effectiveness. • Led the development of a next generation optogenetics based HTS screening assays for voltage-gated sodium channels; oversee 200,000 compounds Nav channel HTS campaign, hit validation and subsequent Hit-to-Lead process. • Led the effort to industrialize the Optopatch platform (in vitro electrophysiological methodologies) to study intrinsic excitability and synaptic transmission of primary and human iPSC derived neurons for pain and epilepsy disease modeling. • Oversee the optimization of in vitro cell-based assays, including qPCR, western blot, RNA-Seq for ASO candidate screening and chemistry modification. Oversee the Machine Learning based data analysis for evaluating ASOs functional and toxicologic impacts in neurons. • Served as the project lead of partnered programs with large pharmaceutical companies. Ensure the delivery of high-quality results to partners by working closely with cross functional departments inside the company. • Manage the outsourced work with 7 CRO vendors to execute automated patch clamp recording, compound synthesis for SAR study, in vitro ADME test, and conduct ASO or small molecule PK/PD measurement, toxicity and efficacy test in preclinic rodent models. Engage with non-human primate vendors for in vivo safety and efficacy test.

• Principal Scientist

  • Feb 2019 - Dec 2020

  Cambridge, MA

• Senior Scientist

  • Jan 2017 - Jan 2019

  Cambridge, MA



QuellTx

• Director, Pain Therapeutic Lead

  • Jan 2021 - Present

• Principal Scientist

  • Feb 2019 - Dec 2020

  Cambridge, MA

• Senior Scientist

  • Oct 2018 - Jan 2019

  Cambridge, MA



Harvard University

• United States
• Higher Education
• 700 & Above Employee

• Postdoctoral Fellow

  • Jul 2014 - Dec 2016

  Greater Boston Area



Howard Hughes Medical Institute

• United States
• Research Services
• 700 & Above Employee

• Postdoctoral Fellow

  • Jul 2014 - Jun 2016

  Greater Boston Area