Hanna Kędzierska

In vivo research specialist at ExploRNA Therapeutics
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PL

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Experience

    • Poland
    • Biotechnology
    • 1 - 100 Employee
    • In vivo research specialist
      • Aug 2020 - Present

      I’m responsible for planning and execution of in vivo studies aiming at validation and development of therapeutic tools and approaches in mouse models. I’m responsible for planning and execution of in vivo studies aiming at validation and development of therapeutic tools and approaches in mouse models.

    • Poland
    • Research Services
    • 1 - 100 Employee
    • Postdoctoral Researcher
      • Jan 2018 - Dec 2020

      I did research aiming at discovery of novel targets for cancer immunotherapy. I studied immune system influence on cancer development, and also the role of tumor microenviroment on immune response against cancer. I explored the field of cancer immunotherapy. I was involved in the studies on development and efficacy of therapeutic strategies that may potentiate the anti-tumor immune response against cancer cells. My recent research project has been focused on evaluation of factors that may augment immunomodulatory activity of photodynamic therapy (PDT) and increase anti-cancer immune response to this type of therapy in tumor mouse models.

    • Research And Teaching Assistant
      • Dec 2009 - Sep 2017

      I was focused on the role of splicing factors as well as microRNAs in development of human renal carcinoma and their influence on cellular processes such as apoptosis, proliferation and adhesion in cancer cells. I studied alternative splicing, detected splicing patterns of cancer-related genes, identified cancer-specific splice variants and analyzed their changes in cancer cells vs non-cancerous cells. In my doctoral dissertation I concerned on the role of one of the splicing factor, SRSF2 in regulation of apoptosis in human renal cancer. In my research, using common molecular biology techniques I revealed that decreased action of SRSF2, discovered in ccRCC affects regulation of apoptosis possibly by modulation of splicing and expression of genes, involved directly in induction and control of this process. The results of this study have been published recently in the International Journal of Molecular Science, DOI: 10.3390/ijms17101598.

Education

  • Centre of Postgraduate Medical Education
    Doctor of Medical Science- PhD
  • Uniwersytet Warmińsko-Mazurski w Olsztynie
    Magister (Mgr), Biotechnologia
    2003 - 2008

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