Rusli Yeo 楊楚源
Manager, Technical Services & Validation at Hilleman Laboratories- Claim this Profile
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Indonesian Elementary proficiency
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English Full professional proficiency
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Chinese Native or bilingual proficiency
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Malay Elementary proficiency
Topline Score
Bio
Credentials
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Critical Thinking for Better Judgment and Decision-Making
LinkedInJan, 2021- Oct, 2024 -
Effective Listening
LinkedInJan, 2021- Oct, 2024 -
Microsoft Teams Essential Training
LinkedInApr, 2020- Oct, 2024
Experience
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Hilleman Laboratories
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Singapore
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Research Services
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1 - 100 Employee
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Manager, Technical Services & Validation
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Feb 2022 - Present
Responsible for delivering technical services (MS&T) and leading validation activities in first-of-its-kind vaccine and biologics cGMP facility in Singapore As overall validation program owner, drive commisioning, qualification of equipment and validation activities onsite Responsible for delivering technical services (MS&T) and leading validation activities in first-of-its-kind vaccine and biologics cGMP facility in Singapore As overall validation program owner, drive commisioning, qualification of equipment and validation activities onsite
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Novartis
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Switzerland
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Pharmaceutical Manufacturing
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700 & Above Employee
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Senior Process Engineering Expert
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Jun 2016 - Jan 2022
Process Eng -Design, commissioning and qualification of first-in-class biotech facility based on platform technology -Responsible for a smooth start-up of commercial production plant adhering to project KPI's, safety and GMP requirement - lead RCA, process improvement and debottlenecking project, CAPEX expansion studies - schedulepro modelling Qualification /Validation - Concept/plan for SIP and production autoclaves validations - SME onsite for SIP of process equipment qualification and sterilizers (autoclave) -well versed in sterilisation science, physical & biological qualifications and hands-on practical experience -front auditors
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Process Engineering Lead
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May 2015 - Jun 2016
• Lead process design team to provide process engineering design expertise in supporting capital and process improvement projects from feasibility study, concept, basic and detail design phases, construction and commissioning in engineering field • Support and implement global engineering strategy and standards in ensuring adherence of global engineering standards • Perform process and equipment automation concept and functional design development • Manage multiple projects including engineering change and modifications design requirements and fit-out for any tech transfer. • Support site improvement projects and process investigations
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Baxter BioScience Manufacturing SARL Singapore Branch
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Singapore
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Hospitals and Health Care
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1 - 100 Employee
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Senior Process Engineer
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Feb 2012 - May 2015
- Acted as manufacturing user representative for suite expansion project (4BR)- Singlehandedly took charge of the whole upstream manufacturing process adaptation/fit out (i.e., hardware such as PFDs, P&IDs, equipment tech specs, and software functional and design specs) for introducing 2nd product into the expansion suite.- Site SME for nanofiltration process using Planova BioEX hollow fibres, Virosart filters (concept, design, installation, qualification, operation)- Acted as one of the site engineering and manufacturing technology expert - Assisted users in RCA, improvement initiative, control optimization
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Manufacturing Engineer
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Sep 2010 - Feb 2012
+ Commissioned the new bioscience facility to produce recombinant FVIII to treat patients with hemophilia A+ Cell culture operations+ Equipment functional testing, commissioning and cycle development+ Manufacturing Recipe generation and testing and validation
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Lucite International
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United Kingdom
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Chemical Manufacturing
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300 - 400 Employee
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Process Engineer
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Apr 2008 - Sep 2010
Commissioned the first-in-class 120kte capacity Alpha1 process plant producing Methyl Methacrylate (MMA) Pre- and post- start-up activities such as ensuring technical and operating intents are captured in plant process and design and evaluation of process operation performance, indentification of technical constraints On going plant modification identification and specification to address the short & long term process and operational issues. Evaluate specific operational and technical performance criteria such as rate limits, bottlenecks, heat and mass balance deviations, process optimization, product quality, minor components tracking, stabilization performance, control stability and optimization strategies, robustness and short/medium/ long term plan and reliability issues Sizing and rating calculations for chemical process equipment, instrumentation and controls Aspen Hysys simulation and various hydraulics calculations software
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GSK
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United Kingdom
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Pharmaceutical Manufacturing
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700 & Above Employee
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Production Engineer
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2006 - 2008
Value Stream * Production of Intermediate stages for API involving various unit operations in pharmaceutical industry such as dissolution, crystallisation, solvent extraction, centrifugation, drying, CIP and sanitisation * Adhered to production schedule to meet yield and production volume timely and efficiently * investigation leader for deviation, CAPA. * SAP Superuser * MES & EBR * Operator training Value Stream * Production of Intermediate stages for API involving various unit operations in pharmaceutical industry such as dissolution, crystallisation, solvent extraction, centrifugation, drying, CIP and sanitisation * Adhered to production schedule to meet yield and production volume timely and efficiently * investigation leader for deviation, CAPA. * SAP Superuser * MES & EBR * Operator training
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Education
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2002 - 2005
National University of Singapore (NUS)
Bachelor of Engineering (Chemical), Chemical Engineering -
1998 - 2001
Singapore Polytechnic (SP)
Diploma in Chemical Engineering with Merit, Chemical Engineering
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