Experience

The Technical University of Kenya

• Kenya
• Higher Education
• 200 - 300 Employee

• Lecturer at The Technical university of Kenya

  • May 2023 - Present



Helmholtz Centre for Infection Research

• Germany
• Research Services
• 200 - 300 Employee

• Postdoctoral Scientist

  • Feb 2021 - Apr 2023

  I use in vitro screening methods to identify potential antimicrobial agents from a collection of natural or synthetic small molecule libraries. The main focus is the high-throughput screening-based discovery of small molecules against Chikungunya virus infection. In parallel, I also screen for molecules with anti-growth properties against Staphylococcus aureus, Escherichia coli, Acinetobacter baumannii, or those targeting their virulence factors. I use in vitro screening methods to identify potential antimicrobial agents from a collection of natural or synthetic small molecule libraries. The main focus is the high-throughput screening-based discovery of small molecules against Chikungunya virus infection. In parallel, I also screen for molecules with anti-growth properties against Staphylococcus aureus, Escherichia coli, Acinetobacter baumannii, or those targeting their virulence factors.



The Technical University of Kenya

• Kenya
• Higher Education
• 200 - 300 Employee

• Assistant Lecturer

  • Dec 2015 - May 2021

• Assistant Lecturer

  • Aug 2013 - Nov 2015



Helmholtz Centre for Infection Research

• Germany
• Research Services
• 200 - 300 Employee

• PHD Student

  • Oct 2016 - Oct 2020

  My thesis, entitled “Immune Escape of T-cell Recognition by Murine Cytomegalovirus” focused on evaluating the long-term outcome of adoptive immunotherapy with CMV-specific T-cells. A mouse model of cytomegalovirus disease using recombinant murine cytomegalovirus (MCMV) expressing immunodominant epitopes in various gene contexts was used. The main findings of the study were that: (1) T-cells targeting epitopes expressed in the immediate early or early phases of MCMV replication provided temporary immune protection that was independent of the phenotype, clonal size, or T-cell supply. (2) Immune escape of T-cell recognition by MCMV through mutation of the cognate epitope when expressed in a single genome location was identified as the cause of poor long-term control of virus replication. (3) Targeting multiple viral antigens provided better control of virus replication and long-term immune control of CMV disease. Taken together, these data argue that adoptive T-cell immunotherapy of CMV disease requires targeting multiple CMV epitopes to minimize the risk of virus-immune escape. Show less



University of Nairobi

• Kenya
• Higher Education
• 700 & Above Employee

• Graduate Assistant

  • Jan 2014 - Dec 2015