Experience

Treeline Biosciences

• United States
• Biotechnology
• 100 - 200 Employee

• Senior Scientist

  • Aug 2021 - Present



Blueprint Medicines

• United States
• Biotechnology Research
• 400 - 500 Employee

• Scientist II

  • Jan 2021 - Aug 2021

  - Designed a series of outsourced target validation screening studies to assess potency of novel inhibitors across a broad set of cell lines in a genetically defined oncology indication, leading to follow-up studies that validated our mechanism of action (MOA) hypotheses - Executed a series of compound rescue studies to confirm on- and off-target dependencies in our cell line models of interest - Lead efforts to design, optimize, and outsource a routine proliferation assay to assess new… Show more - Designed a series of outsourced target validation screening studies to assess potency of novel inhibitors across a broad set of cell lines in a genetically defined oncology indication, leading to follow-up studies that validated our mechanism of action (MOA) hypotheses - Executed a series of compound rescue studies to confirm on- and off-target dependencies in our cell line models of interest - Lead efforts to design, optimize, and outsource a routine proliferation assay to assess new compound matter. - Designed and executed a series of studies to discover and validate novel biomarkers relevant to our target of interest - Validated novel targets relevant to cancer kinase biology using various RNAi (shRNA, CRISPR) and protein overexpression tools

• Scientist I

  • Dec 2018 - Jan 2021



Novartis

• Switzerland
• Pharmaceutical Manufacturing
• 700 & Above Employee

• Scientist II

  • Sep 2017 - Dec 2018

  Small molecule drug discovery role in oncology that covers a range of topics and development phases, from Target ID through preclinical validation - Evaluated clinical profiling data to assess the resistance setting for PKC inhibition in uveal melanoma - Assisted in the development of various assays for a novel oncology target to assess target engagement with small molecule inhibitors - utilize RNAi technology (e.g. shRNA, CRISPR) and tool compounds to interrogate pathways… Show more Small molecule drug discovery role in oncology that covers a range of topics and development phases, from Target ID through preclinical validation - Evaluated clinical profiling data to assess the resistance setting for PKC inhibition in uveal melanoma - Assisted in the development of various assays for a novel oncology target to assess target engagement with small molecule inhibitors - utilize RNAi technology (e.g. shRNA, CRISPR) and tool compounds to interrogate pathways relevant to novel cancer targets - develop cell-based screening assays and identify biomarkers to enable small molecule drug discovery - utilize internal, purpose-built pipelines to process and analyze RNAseq experiments; create visualizations to answer key scientific questions; mine additional databases to answer any follow up questions; present findings and next steps at team meetings

• Scientist I

  • Mar 2012 - Sep 2017

  - completed a sabbatical in the Oncology Bioinformatics group, where I learned to process and analyze RNASeq data using R language; applied newly learned skill sets to compile over 300 internal, historical RNAseq samples across a single genetic setting to find trends in sensitivity/resistance and build a signature score to help predict the efficacy of targeted therapies in this indication - designed and executed a combination screen to find a combination partner for an oncology clinical drug… Show more - completed a sabbatical in the Oncology Bioinformatics group, where I learned to process and analyze RNASeq data using R language; applied newly learned skill sets to compile over 300 internal, historical RNAseq samples across a single genetic setting to find trends in sensitivity/resistance and build a signature score to help predict the efficacy of targeted therapies in this indication - designed and executed a combination screen to find a combination partner for an oncology clinical drug candidate; worked with the assay group to utilize various automation platforms to scale up the screen; validated hits by confirming that the drugs were impacting their targeted pathways; used this information to design additional studies to try to understand the underlying biology behind their synergistic effects

• Scientific Associate II

  • Mar 2010 - Mar 2012



Epizyme

• Research Associate

  • Aug 2008 - Mar 2010

  - build the lab infrastructure to enable discovery research; procure equipment; work with vendors to supply the lab with consumables; ensure the lab is complaint with town, state and federal regulations - execute studies to interrogate the underlying biology behind epigenetic targets; validate shRNAs; perform westerns to confirm knockdown - build the lab infrastructure to enable discovery research; procure equipment; work with vendors to supply the lab with consumables; ensure the lab is complaint with town, state and federal regulations - execute studies to interrogate the underlying biology behind epigenetic targets; validate shRNAs; perform westerns to confirm knockdown



MilliporeSigma

• United States
• Biotechnology Research
• 700 & Above Employee

• Technician

  • 2005 - 2008