Francesco Cacciante, PhD
Software Developer at Siena Imaging srl- Claim this Profile
Click to upgrade to our gold package
for the full feature experience.
Topline Score
Bio
Experience
-
Siena Imaging srl
-
Italy
-
Hospitals and Health Care
-
1 - 100 Employee
-
Software Developer
-
Apr 2022 - Present
-
-
Data scientist
-
Sep 2021 - Apr 2022
-
-
-
Consiglio Nazionale delle Richerche
-
Italy
-
Research Services
-
700 & Above Employee
-
Postdoctoral Researcher
-
Nov 2019 - Nov 2020
I am testing a Gene Therapy approach in order to cure a rare genetic disorder. I introduced and optimized an injection technique in my lab which allowed to cut the injection time by 90% and increase the positive outcome of injections to 100%, dramatically increasing the feasibility of our approach. Examining the clinical data of patients, I was able to confirm also in humans, the viability of our previously found biomarkers. I am testing a Gene Therapy approach in order to cure a rare genetic disorder. I introduced and optimized an injection technique in my lab which allowed to cut the injection time by 90% and increase the positive outcome of injections to 100%, dramatically increasing the feasibility of our approach. Examining the clinical data of patients, I was able to confirm also in humans, the viability of our previously found biomarkers.
-
-
-
Scuola Normale Superiore
-
Italy
-
Research Services
-
700 & Above Employee
-
Molecular biologist/Neuroscientist
-
Nov 2015 - Nov 2019
• Responsible for the “Congenital creatine transporter disorder (CTD): insight into new therapeutic preclinical strategies” project. • Designed and conducted experiments in order to characterize the murine model of the pathology and identify biomarkers. • Evaluated two different preclinical trials. • Performed in-vivo ed ex-vivo surgeries. • Set up protocols to gather and analyze various kind of data (EEG, microscopy, behavior, molecular) • Gathered and analyzed data from human patients and confronted with data obtained from murine model of CTD. • Developed and genotyped genetically modified mice to evaluate cell-specific alterations. • Responsible for experimental animals housing, care, and genotyping, up to 6 different lines. • Responsible for managing, mentoring and advising trainee and students on topics such as study design, data analysis and academic writing. • Delivered high-impact peer-reviewed publications by successfully collaborating with colleagues from multiple disciplines. Show less
-
-
-
-
Extra curricular internship
-
Sep 2014 - Sep 2015
Training in different microscopy techniques for evaluation of dendritic spines plasticity. In vivo 2-photon microscopy, confocal microscopy, dendritic spines plasticity, plasticity markers. Training in different microscopy techniques for evaluation of dendritic spines plasticity. In vivo 2-photon microscopy, confocal microscopy, dendritic spines plasticity, plasticity markers.
-
-
-
CNR - Istituto di Fisiologia dei Centri Nervosi
-
Italy
-
Research Services
-
Lavoro di tesi
-
Oct 2013 - Jul 2014
"Cortical plasticity in the primary visual cortex during development: Epigenetic mechanisms in a murine model of monocular deprivation" Epigenetic regulation, miRNAs, PCR, rt-PCR, real-time PCR, ChIP, monocular deprivation. "Cortical plasticity in the primary visual cortex during development: Epigenetic mechanisms in a murine model of monocular deprivation" Epigenetic regulation, miRNAs, PCR, rt-PCR, real-time PCR, ChIP, monocular deprivation.
-
-
Education
-
Università degli studi di Siena
Master of Science - MS, Data Science -
Scuola Normale Superiore
Doctor of Philosophy - PhD, Neuroscience -
Università degli Studi di Firenze
Laurea Magistrale LM, Biologia molecolare -
Università degli Studi di Firenze
Laurea breve, Biologia, generale