Experience

PILI

• France
• Biotechnology Research
• 1 - 100 Employee

• Research Engineer

  • Jan 2019 - Present



Max Planck Institute

• Research Services
• 200 - 300 Employee

• Postdoctoral Fellow (Prof. Alois Fürstner's group)

  • Apr 2016 - Mar 2018

  Investigations of Transition Metal Catalyzed Cascade Reactions Investigations of Transition Metal Catalyzed Cascade Reactions



CNRS

• France
• Research Services
• 700 & Above Employee

• PhD Researcher Student (Prof. Max Malacria's team)

  • Oct 2012 - Oct 2015

  Prof. Max Malacria Biaryl coupling by photoredox catalysis The development of new methods for the efficient production of biaryl compounds remains of synthetic interest, as these compounds are frequently found in natural products, drugs, and materials. We developed a simple and convenient method to assemble biaryls, exploiting a photoredox catalyst and visible light. Diazonium salts generate aryl radicals that can then add to unactivated (hetero)arenes, and the reaction sequence eventually delivers the desired biaryl products via formal homolytic aromatic substitutions. The direct C–H arylation of these typically unreactive substrates was achieved at room temperature using low catalyst loadings, and showed broad functional group tolerance. Total synthesis of Marmycin A Anthracyclines such as doxorubicin are used extensively for treating cancer patients. Anthraquinone-related angucyclines also exhibit antiproliferative properties, and have been proposed to operate via similar mechanisms, including direct genome targeting. We realized the chemical synthesis of marmycin A and studied its cellular activity. The aromatic core was constructed via a one-pot multistep reaction comprising a regioselective Diels–Alder cycloaddition, and the complex sugar backbone was introduced through a copper-catalyzed Ullmann cross-coupling, followed by a challenging Friedel–Crafts cyclization. Remarkably, fluorescence microscopy revealed that marmycin A does not target the nucleus but instead accumulates in lysosomes, thereby promoting cell death independently of genome targeting. These findings shed light on the elusive pathways through which anthraquinone derivatives operate in cells, which may influence their biological and therapeutic applications. Show less



Paris-Sud University (Paris XI)

• France
• Higher Education
• 500 - 600 Employee

• Internship in Organic Chemistry

  • Jan 2012 - Jul 2012

  Dr Nicolas Rabasso Preparation of α-Amino Allenephosphonates α-Amino allenephosphonates were easily prepared in two steps from protected amines, propargyl alcohols, and chlorophosphites. First, ynamides were synthesized from unprotected 1-bromopropargyl alcohols using a copper-catalyzed coupling reaction. In the second step, the ynamides were transformed directly to allenes through a [2,3]-sigmatropic rearrangement via in situ generated propargyl phosphites. This efficient method led to the formation of a series of α-amino allenephosphonates with diverse substituents on the amine, the phosphonate, and the allene moieties. α-Amino vinylphosphonates were prepared by the chemo- and stereoselective reduction of α-amino allenylphosphonates. Our results demonstrated that the substituents on the allene, phosphonate, and amine moieties affected the stereoselectivity of the reduction. (Z)-α-Amino vinylphosphonates were prepared with selectivities as high as >95:5. Show less



Sanofi

• France
• Pharmaceutical Manufacturing
• 700 & Above Employee

• Internship in Organic Chemistry

  • Mar 2011 - Aug 2011

  Florian Auger / Dr Antonio Almario's team Synthesis of chemical probes used in medical imaging Florian Auger / Dr Antonio Almario's team Synthesis of chemical probes used in medical imaging



Paris-Sud University (Paris XI)

• France
• Higher Education
• 500 - 600 Employee

• Internship in Organic Chemistry

  • Apr 2009 - Jun 2009

  Dr Nadine Aubry-Barroca / Pr David Bonnaffé's team Introduction of benzyl/p-methoxybenzyl groups in mild conditions on sugar derivatives Dr Nadine Aubry-Barroca / Pr David Bonnaffé's team Introduction of benzyl/p-methoxybenzyl groups in mild conditions on sugar derivatives