Fengling Liu
Director of Protein Science at Juvena Therapeutics- Claim this Profile
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Experience
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Juvena Therapeutics
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United States
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Biotechnology Research
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1 - 100 Employee
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Director of Protein Science
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2022 - Present
Redwood City, California, United States
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Arcus Biosciences
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United States
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Biotechnology
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300 - 400 Employee
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Principal Investigator, group lead of Protein Science
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2020 - 2022
Hayward, California, United States
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Atreca, Inc.
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United States
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Biotechnology Research
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1 - 100 Employee
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Sr. Scientist, Protein Biochemistry-Antibody target identification and conformation
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2019 - 2020
South San Francisco, California, United States
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Relypsa
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United States
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Biotechnology Research
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1 - 100 Employee
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Staff Scientist, Protein Biochemistry and assay development
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2016 - 2018
Redwood City, California, United States
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AstraZeneca
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United Kingdom
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Pharmaceutical Manufacturing
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700 & Above Employee
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Scientist II, Protein Biochemistry-Lead optimization
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2010 - 2013
Mountain View, California, United States • Served as the biochemistry lead in multiple cross-functional teams for subunit vaccine development against infectious diseases •Established a CHO transient expression platform for difficult-to-express viral glycoproteins production (titer improved 50-100 fold) for immunizations • Successfully optimized protein targets by reducing aggregation and heterogeneity using structure-based protein engineering • Excellent in protein purification method development and… Show more • Served as the biochemistry lead in multiple cross-functional teams for subunit vaccine development against infectious diseases •Established a CHO transient expression platform for difficult-to-express viral glycoproteins production (titer improved 50-100 fold) for immunizations • Successfully optimized protein targets by reducing aggregation and heterogeneity using structure-based protein engineering • Excellent in protein purification method development and characterization tools (e.g., HPLC, DLS and ELISA) • Supervised multiple associates and managed CROs Show less
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Stanford University School of Medicine
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Hospitals and Health Care
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1 - 100 Employee
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Postdoctoral Researcher, Protein biochemistry and Crystal Structural studies
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2007 - 2010
• Studied human herpesvirus Epstein-Barr Virus (EBV) and cytomegalovirus (CMV) glycoprotein interactions to dissect viral entry mechanisms • Designed multiple glycoprotein and Fab constructs for gene synthesis • Expressed multiple glycoproteins (up to 5 proteins co-transfection) in baculovirus/insect cells and HEK293 to study protein-protein interactions • Developed and optimized a fluorescence polarization binding (protein-protein or peptide) assay for high throughput… Show more • Studied human herpesvirus Epstein-Barr Virus (EBV) and cytomegalovirus (CMV) glycoprotein interactions to dissect viral entry mechanisms • Designed multiple glycoprotein and Fab constructs for gene synthesis • Expressed multiple glycoproteins (up to 5 proteins co-transfection) in baculovirus/insect cells and HEK293 to study protein-protein interactions • Developed and optimized a fluorescence polarization binding (protein-protein or peptide) assay for high throughput screening of small molecule libraries for EBV entry inhibitors • Crystallized protein complexes with small molecules Show less
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Education
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Georgia State University
PhD, Molecular Biology, protein engineering and Crystallography -
Zhongshan University
Master of Science (MS), Life sciences