Emilie Da Costa

Senior Radiochemist at Debiopharm
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Contact Information
us****@****om
(386) 825-5501
Location
CH
Languages
  • Anglais Full professional proficiency
  • Espagnol Limited working proficiency
  • Français Native or bilingual proficiency
  • Allemand Elementary proficiency
Skills

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Credentials

  • Conseiller en Radioprotection (PCR) - Médical - Sources scellées (Radiation Safety Officer, medical, unsealed sources)
    Conservatoire National des Arts et Métiers
    Jul, 2019
    - Nov, 2024
  • Personne Compétente en Radioprotection (PCR) - Médical - Sources scellées (Radiation Safety Officer, medical, unsealed sources)
    IRSN
    Jul, 2014
    - Nov, 2024

Experience

  • Debiopharm
    • Switzerland
    • Pharmaceutical Manufacturing
    • 300 - 400 Employee
    • Senior Radiochemist
      • Jul 2021 - Present

      Department of Pharmaceutical Development - Development and manufacturing of theranostic radiopharmaceuticals for multicenters clinical trials in oncology - Development of innovative radiopharmaceuticals - Preparation of drug product supply strategy: outsourcing of manufacturing of chemicals APIs and radiopharmaceuticals - Managing of CDMOs/vendors activities - Managing of external radiopharmacies activities - Definition of technical & regulatory API strategy - Scientific and regulatory watch regarding radiopharmaceuticals - Close collaboration with clinical operations, translational medicine, marketing intelligence, legal department, hospitals…

  • Institut Curie
    • France
    • Hospitals and Health Care
    • 700 & Above Employee
    • Radiopharmaceutical chemist / Production manager / Radiochemist
      • Dec 2013 - Sep 2021

      Head of the cyclotron GMP R&D unit. Production manager of the cyclotron unit. Department of Radiopharmacology. Research team : LITO (Laboratory of Translational Imaging for Oncology), INSERM UMR1288 * In charge of development of PET tracers radiosyntheses: - Fully cGMP and cGRPP-compliant production of fluorine-18 and gallium-68 labeled target molecules for oncology, in the Cyclotron unit - Development of labelled molecules for theranostic (68Ga ; soon 64Cu, 89Zr and 177Lu) - Implementation of manufacturing and shipping of gallium-68 radiopharmaceuticals in the Department of Nuclear Medicine - Automated syntheses on different commercial synthesizers (GE Healthcare MX, FX-FN, FX Cpro ; Trasis AllinOne & miniAIO...etc) - Development and validation of QC methods - Implementation of GMP & QMS for cyclotron unit - Writing of IMPD & SOP - Cancer clinical trials - Collaboration with pharmaceutical companies - Management and training of operators and students * Radiation Safety Officer (certified in France)

  • Advanced Accelerator Applications
    • France
    • Pharmaceutical Manufacturing
    • 700 & Above Employee
    • PhD - Radiochemistry & Organic Chemistry
      • Nov 2010 - Nov 2013

      Development of a first radiofluorinated tracer for PET imaging of acetylcholinesterase and follow-up of neurodegenerative diseases such as Alzheimer's disease. - Synthesis of precursors and non radioactive analogues of tracers - Determination of IC50 - Fluorine-18 labelling & full automation on GE TRACERlab FX & MX synthesizers - Development of a bimodal PET/fluorescence imaging probe - In vitro and in vivo evaluation of tracers - Pre-clinical studies on mice, rats and cats - Management and training of new interns and students

  • Advanced Accelerator Applications
    • France
    • Pharmaceutical Manufacturing
    • 700 & Above Employee
    • End of study project - Radiochemistry
      • Mar 2010 - Sep 2010

      Fluorine-18 labelling of peptides for their in vivo evaluation by PET imaging - Development of prosthetic groups - Click chemistry - Automation on GE TRACERlab FX & MX synthesizers - in vitro & in vivo studies of the labelled peptides Fluorine-18 labelling of peptides for their in vivo evaluation by PET imaging - Development of prosthetic groups - Click chemistry - Automation on GE TRACERlab FX & MX synthesizers - in vitro & in vivo studies of the labelled peptides

  • ANSTO
    • Australia
    • Research Services
    • 700 & Above Employee
    • Research internship - Radiochemistry & Organic chemistry
      • Mar 2009 - Aug 2009

      Development of new peripheral benzodiazepine receptor ligands labelled with fluorine-18 - Synthesis of precursors for fluorine-18 & iodine-123 labelling - Determination of IC50 - Fluorine-18 labelling - Preclinical studies on baboons Development of new peripheral benzodiazepine receptor ligands labelled with fluorine-18 - Synthesis of precursors for fluorine-18 & iodine-123 labelling - Determination of IC50 - Fluorine-18 labelling - Preclinical studies on baboons

  • GIP CYCERON
    • France
    • Research Services
    • 1 - 100 Employee
    • Research internship - Organic Chemistry for PET imaging
      • Jan 2008 - Feb 2008

      Synthesis of molecules and precursors for their use in Positron Emission Tomography (PET) imaging Synthesis of molecules and precursors for their use in Positron Emission Tomography (PET) imaging

Education

  • ETH Zürich
    CAS Radiopharmaceutical chemistry & Radiopharmacy, Radiochemistry, radiopharmacy &radiopharmacology
    2019 - 2021
  • Université de Rouen Normandie
    Doctor of Philosophy - PhD, Organic chemistry
    2010 - 2013
  • ENSICAEN - Ecole Nationale Supérieure d'Ingénieurs de Caen
    Ingénieur Chimie Fine (M.Eng), Chimie
    2008 - 2010
  • Université de Caen Normandie
    Master 2 Recherche (M.Sc), Organic chemistry
    2005 - 2010

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