Elliot Goodfellow, PhD
Senior Scientist at Repare Therapeutics- Claim this Profile
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Topline Score
Bio
Experience
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Repare Therapeutics
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Canada
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Biotechnology Research
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100 - 200 Employee
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Senior Scientist
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Jan 2023 - Present
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Centre universitaire de santé McGill | McGill University Health Centre
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Canada
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Hospitals and Health Care
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700 & Above Employee
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Postdoctoral Research Fellow
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Jan 2022 - Dec 2022
Supervisor: Dr. Pnina Brodt Generated protein structures for small molecule docking in silico. Performed chemical synthesis to design molecules/NCEs and characterized them by mass spectrometry (MS), high pressure liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) spectroscopy. Biologically assessed synthesized molecules in vitro and ex vivo to confirm feasibility as a monotherapy in pancreatic cancer cell lines. Assessed pharmacodynamics and pharmacokinetics of lead candidates in vivo using syngeneic mouse models. Show less
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Centre universitaire de santé McGill | McGill University Health Centre
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Canada
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Hospitals and Health Care
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700 & Above Employee
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Doctoral Student
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Sep 2015 - Aug 2021
Supervisor: Dr. Bertrand Jean-Claude Performed chemical synthesis to design molecules/NCEs and characterized them by mass spectrometry (MS), high pressure liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) spectroscopy. Biologically assessed the mechanism of action in vitro of NCEs on the Met receptor and DNA synthesis in gastric and lung cancers. Trained numerous students and fellows of various graduations in either chemistry or biology. Supervisor: Dr. Bertrand Jean-Claude Performed chemical synthesis to design molecules/NCEs and characterized them by mass spectrometry (MS), high pressure liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) spectroscopy. Biologically assessed the mechanism of action in vitro of NCEs on the Met receptor and DNA synthesis in gastric and lung cancers. Trained numerous students and fellows of various graduations in either chemistry or biology.
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Hospital de Cancer de Barretos Fundação PIO XII
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Brazil
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Wellness and Fitness Services
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500 - 600 Employee
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Visiting Doctoral Student
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Jan 2017 - Mar 2017
Supervisor: Dr. Rui Reis Biologically assessed the mechanism of action in vitro of NCEs on the Met receptor and DNA synthesis in lung cancer cell lines of varying EGFR status. Supervisor: Dr. Rui Reis Biologically assessed the mechanism of action in vitro of NCEs on the Met receptor and DNA synthesis in lung cancer cell lines of varying EGFR status.
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McGill University
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Canada
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Higher Education
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700 & Above Employee
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Master Thesis Student
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Jan 2013 - Feb 2016
Supervisor: Dr. Bertrand Jean-Claude Performed chemical synthesis to design molecules/NCEs and characterized them by mass spectrometry (MS), high pressure liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) spectroscopy. Biologically assessed in vitro the mechanism of action of two homologous series on PARP function and DNA damage in an isogenic set of cells lines differing in their BRCA2 status. Supervisor: Dr. Bertrand Jean-Claude Performed chemical synthesis to design molecules/NCEs and characterized them by mass spectrometry (MS), high pressure liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) spectroscopy. Biologically assessed in vitro the mechanism of action of two homologous series on PARP function and DNA damage in an isogenic set of cells lines differing in their BRCA2 status.
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AGAT Laboratories
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Canada
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Oil and Gas
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700 & Above Employee
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Analyst 3
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Mar 2012 - Dec 2012
Analysis of trace metal content in environmental soil and water samples using ICP-OES and ICP-MS. Analysis of trace metal content in environmental soil and water samples using ICP-OES and ICP-MS.
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MediMabs Antibodies
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Canada
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Biotechnology
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1 - 100 Employee
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Technician
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May 2011 - Aug 2011
Performed protein purifications and validations experiments to confirm target specificity. Developed Excel spreadsheets to facilitate screening and confirmation of "positive" hits. Performed protein purifications and validations experiments to confirm target specificity. Developed Excel spreadsheets to facilitate screening and confirmation of "positive" hits.
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Education
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McGill University
Doctor of Philosophy - PhD, Experimental Medicine -
McGill University
Master's degree, Pharmacology -
Concordia University
Bachelor's degree (Honours), Chemistry