Elisabeth Brown

Oncological Sciences PhD Candidate at University of Utah
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Contact Information
us****@****om
(386) 825-5501
Location
Salt Lake City, Utah, United States, US

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Experience

  • University of Utah
    • Salt Lake City, Utah, United States
    • Oncological Sciences PhD Candidate
      • Aug 2020 - Present

      PhD candidate and MS of Clinical Investigation candidate in the Welm Lab Gancer Genetics, Epigenetic, Models and Signaling (GEMS) T32 Training Program Thesis Project Title: Determinants of Birinapant Efficacy in Triple-Negative Breast Cancer Campus Involvement: Oncological Sciences Department Student Advisory Committee (STAC) PhD candidate and MS of Clinical Investigation candidate in the Welm Lab Gancer Genetics, Epigenetic, Models and Signaling (GEMS) T32 Training Program Thesis Project Title: Determinants of Birinapant Efficacy in Triple-Negative Breast Cancer Campus Involvement: Oncological Sciences Department Student Advisory Committee (STAC)

  • Repertoire Immune Medicines
    • Cambridge, Massachusetts
    • Associate Scientist
      • Jun 2018 - Aug 2020

      Cell Processing & Development Team -Developed a small-scale model of the GMP cell manufacturing processing for use in processing low volumes (<100mL) of patient apheresis and whole blood material, and to create a reliable proof of concept model system for use across the company -Optimization and operation of automated, closed-system cell separation and media exchange/concentration devices to improve harvest yield and empower higher dose cohorts for RIM’s Phase I clinical trial -Designed and implemented experiments to enable Investigational New Drug (IND) filings and amendments to the FDA for the IL-15 and IL-12 pipelines -Lead conceptual and technical trainer of new GMP operators and RIM employees on the cell manufacturing process -Support of RIM’s three clinical manufacturing sites through batch record updates,tech transfer, and deviation management -Routine Flow Cytometry analysis of in-house experiments and cross-group collaborator for new analytical panel design and implementation Show less

    • Undergraduate Research Assistant - Sulchek Lab
      • Aug 2015 - May 2018

      Atomic force microscopy (AFM) analysis -Characterized the mechanical properties of healthy lymphatic smooth muscle cells. -Tested for cellular functionality after intentional damage to adjacent muscle cells. -Analyzed lymphatic cell interactions with various softening or stiffening agents. Atomic force microscopy (AFM) analysis -Characterized the mechanical properties of healthy lymphatic smooth muscle cells. -Tested for cellular functionality after intentional damage to adjacent muscle cells. -Analyzed lymphatic cell interactions with various softening or stiffening agents.

    • Research And Development Intern
      • Jan 2017 - May 2017

      - Planned, executed and analyzed experiments transitioning a basic protocol into a defined, GMP compliant process for cell manufacturing. - Operated closed system, large scale cell processing equipment including the Elutra, Lovo, and Quantum. - Performed flow cytometry staining and acquisition to characterize cell phenotype and composition to advance flow panel development and characterize cells resulting from process changes. - Performed and optimized Intracellular Cytokine Staining (ICS) and ELISpot assays to quantify the function of antigen specific cells generated by cell cultures and determined which process changes had the largest impact on generating higher frequencies of antigen specific cells. - Performed lab managerial duties, including lab maintenance, inventory, and stocking of essential lab materials. Show less

Education

  • Georgia Institute of Technology
    Bachelor of Science (B.S.), Biomedical Engineering with a certificate in Biomedical Sciences and Research Option distinction
    2014 - 2018
  • University of Utah
    Doctor of Philosophy - PhD, Molecular Biology
    2020 -

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