Dylan Verden
Neuroscience Graduate Student at University of Colorado Anschutz Medical Campus- Claim this Profile
Click to upgrade to our gold package
for the full feature experience.
Topline Score
Bio
Credentials
-
Dylan Verden
Mentor CollectiveApr, 2021- Oct, 2024
Experience
-
University of Colorado Anschutz Medical Campus
-
United States
-
Higher Education
-
700 & Above Employee
-
Neuroscience Graduate Student
-
Aug 2014 - Present
I currently study antioxidant signaling in myelin development and injury.Stroke is a devastating injury caused by altered blood flow to the brain. The initial metabolic injury can involve both under- and overexposure to oxygen and glucose, and is followed by long-term inflammation. Strokes' sudden, localized onset and rapidly evolving symptoms create a complex environment that is difficult to treat by any one method.Further complicating the issue, the brain's response to injury depends both on the type of insult and the baseline physiological state during injury. Throughout childhood and adolescence the brain undergoes massive metabolic changes in order to create and consolidate its networks. This includes not only neurons but the cells that support neuronal function. Previous mouse work in our lab has shown that during juvenile development, the brain's "white matter," composed of long range neuronal connections, is highly resistant to damage from ischemic stroke.Myelin is the specialized fatty membrane that gives white matter its name. Myelin ensheathes connections between neurons and facilitates fast, reliable, precise electrical signaling. It is created by oligodendrocytes, which can produce over 100x their own weight in myelin; this process imposes intense metabolic demands that can create byproducts like free radicals that damage cellular membranes, proteins, and DNA. Damaging myelin in this way can create massive amounts of debris that drive inflammation and injury, so it is crucial that oligodendrocytes tightly coordinate their metabolic needs and capacity.We hypothesize that during juvenile myelin production, oligodendrocytes are primed to handle excess oxidative stress with antioxidant systems, and that this developmental stage allows white matter myelin resist oxidative injuries like stroke.
-
-
-
Regions Hospital
-
United States
-
Hospitals and Health Care
-
700 & Above Employee
-
Research Assistant
-
May 2012 - Jul 2014
I studied the use of intranasal drug administration as a method of bypassing the blood brain barrier to deliver therapeutics at low, localized doses in rat models of late-onset Alzheimer's (STZ) and Parkinson's Disease (6-OHDA). We utilized behavioral assays for memory, motor function, and stress to determine functional recovery. I studied the use of intranasal drug administration as a method of bypassing the blood brain barrier to deliver therapeutics at low, localized doses in rat models of late-onset Alzheimer's (STZ) and Parkinson's Disease (6-OHDA). We utilized behavioral assays for memory, motor function, and stress to determine functional recovery.
-
-
Education
-
-
University of Minnesota-Twin Cities
Bachelor of Science - BS, Neuroscience
Community
