Principal Bioinformatics Scientist

• Feb 2022 - Present

Senior Bioinformatician

• Jan 2021 - Feb 2022

Bioinformatician III

• Jun 2019 - Jan 2021

Post Doctoral Associate

• Oct 2017 - Jun 2019

Working with various in-house and collaborative projects towards causative gene finding for neurological genetic disorder using state of art methods with DNASeq and RNASeq data analysis.Participated actively in updating SQL based ALS Variant Server (http://als.umassmed.edu/) with recent KIF5A finding.Currently involved in the discovery of Parkinson’s Disease gene with whole exome and whole genome large scale case control cohort datasets.Developing and maintaining variant calling, annotation and rare variant finding pipeline for whole genome and whole exome datasets.Managing high end Unix RAID servers and storage to manage Petabyte size datasets. Show less

Postdoctoral Researcher

• Feb 2013 - Oct 2017

Worked on Whole Exome and Whole Genome next generation sequence data analysis at Huff Lab, Department of Epidemiology, MD ANDERSON CANCER CENTER, Houston, Texas, USA. Designed Disease risk prediction modeling tool PREdiction by SUpervised Learning Toolkit (PRESULT) to simplify the development, validation and optimization of machine learning (ML) risk prediction models using various epidemiological and genetic datasets. The tool produces portable models and program objects that can be distributed and used for validation or prediction on new datasets. (http://www.hufflab.org/software/presult/) Actively participated as a team member for designing and conducting experiments for the development and publication of Pedigree Variant Annotation, Analysis, and Search Tool (pVAAST). pVAAST is a Software tool for identifying genetic variants that directly influence disease risk in families.(http://www.hufflab.org/software/pvaast/) Participated as a team member for generating the results and publication of second version ERSA 2.0. ERSA (Estimation of Recent Shared Ancestry) estimates recent shared ancestry between pairs of individuals based on the number and lengths of chromosomal segments that they share identically-by-descent through common ancestors (IBD segments). (http://www.hufflab.org/software/ersa/) Tested Genetic Anticipation and calculated Mutation rate estimate in Lynch syndrome using Whole Genome DNA sequence data. Performed mapping, variant analysis of 8 quartets and quintets Lynch syndrome families with 3 trio control families. We applied general purpose and pedigree aware variant callers for variant calling. Show less

FACULTY

• Dec 2006 - Dec 2012

* Worked as Associate Lecturer at Department of Biotechnology, Birla Institute of Technology, Mesra, Ranchi. *Here I was involved in regular academic as well as research activities related to Bioinformatics. Also Involved in the development of various softwares and databases such as easy interface for homology modelling "Swift Modeller", atom-ion domain detection tool for protein structure and sequence "Predict @proteommetal" and "Infectious Disease Database" etc. * Worked and developed Pre-diabetes risk prediction model and detection tool for Indian population. *Published more than 20 articles in journal of repute in Bioinformatics. Show less