Experience

3B Pharmaceuticals GmbH

• Germany
• Pharmaceutical Manufacturing
• 1 - 100 Employee

• Manager peptide synthesis/Project Management

  • Apr 2020 - Present

  Development of targeted radiopharmaceuticals as cancer theragnostics



Charité Comprehensive Cancer Center / Robert Koch Institute

• Product developer / Biochemist / postdoc

  • Aug 2017 - Feb 2020

  Biochemical development of a therapeutic vaccine against cancers in the context of the GO-Bio project AmpliVak- R & D in the laboratories of Prof. Dr. med. Richard Kroczek (molecular immunology)- design, recombinant expression, purification and characterization of vaccine candidates- development of a lead agent- protein chemistry: protein refolding, development of a bioconjugation strategy for site specific labeling of proteins. Development of suitable analytical and preparative methods for the purification and characterization of the labeled proteins.



University of Konstanz

• Germany
• Research Services
• 700 & Above Employee

• Research Associate

  • Dec 2010 - Sep 2016

  Doctoral research on "Target identification of a small molecule rescuing monastrol-induced spindle defects" in the laboratories of Prof. Thomas U. Mayer (from June 2016 on postdoctoral fellow)- analysis of the molecular mode of action of the bioactive small molecule MAC1- characterization of the biological phenotypes of MAC1 in mammalian cells- synthesis and screen of a derviative library, structure-activity-relationship (SAR) studies,- lead compound optimization and functionalization: conjugation of MAC1-derivatives to solid supports and reporter groups- affintiy purification of interaction partners and mass spectrometric analysis of these- investigation of MAC1 with its biochemical targets in in vitro and cellular assays- analysis of microtubule dynamics, mitotic spindle formation and lipid metabolism- teaching and lecturing of university classes and laboratory courses- presentation of research data in scientific talks and posters at international conferences- preparation of manuscripts for scientific peer-reviewed publishing and participation in peer review of other researchers’ manuscripts- numerous collaborations, amongst others with Harvard Medical School, University of Amsterdam, ETH Zürich, EMBL Heidelberg- relevant scientific illustration work



Humboldt-Universität zu Berlin

• Germany
• Higher Education
• 700 & Above Employee

• Diplomarbeit / Degree Project

  • Oct 2009 - Jul 2010

  - under guidance of Prof. Oliver Seitz, in collaboration with Michael J. Gait, PhD at the MRC Laboratory of Molecular Biology in Cambridge, UK- research topic: Cyanine-based FIT-PNA probes as tools for microRNA detection and localization studies- organic synthesis of a fluorescent PNA monomer for application in Fmoc chemistry- design, synthesis and analytical characterization (HPLC, MALDI) of functionalized PNA-oligonucleotides by (automated) solid phase peptide synthesis - biophysical characterization (measurement of fluorescence & melting temperatures) of the PNA oligomers- evaluation of the cellular effects of the novel tools (confocal microscopy, northern blots)



MRC Laboratory of Molecular Biology (LMB)

• United Kingdom
• Research Services
• 200 - 300 Employee

• Visiting Scientist

  • Nov 2009 - Feb 2010

  Scientific visit to the lab of Michael J. Gait, PhDCollaboration work in the context of the Diplomarbeit (final degree project)



Humboldt-Universität zu Berlin

• Germany
• Higher Education
• 700 & Above Employee

• Student Assistant

  • Nov 2008 - Jul 2009

  Student assistant of the general and the inorganic chemistry laboratory



Uppsala University

• Sweden
• Higher Education
• 700 & Above Employee

• Research training

  • Jun 2008 - Jul 2008

  - in the laboratories of Prof. Mikael Widersten- research topic: Optimizing a colorimetric assay suitable for screening epoxide hydrolase activity in cell lysates



Humboldt-Universität zu Berlin

• Germany
• Higher Education
• 700 & Above Employee

• Research Trainee

  • Feb 2007 - Apr 2007

  - in the laboratories of Prof. Christoph Arenz- research topic: Synthesis of ether-linked phosphoglycerols as potential chemical chaperones for the experimental therapy of Niemann Pick Disease