PRINCIPLE TEAM LEADER, RESEARCH & TECHNOLOGY, SYNGENTA BIOSCIENCES PVT LTD

• Apr 2023 - Present

SENIOR TEAM LEADER

• Aug 2022 - Apr 2023

We are in a business that helps humanity face its toughest challenge: how to feed a rising population, sustainably. Our world class science and innovative crop solutions transform how crops are grown to enable millions of growers to make better use of available resources. Our business – and the world’s food security – depend on sustainable natural resources, healthy ecosystems and thriving rural communities. Research and Development (R&D) is the innovation engine of Syngenta and is crucial… Show more We are in a business that helps humanity face its toughest challenge: how to feed a rising population, sustainably. Our world class science and innovative crop solutions transform how crops are grown to enable millions of growers to make better use of available resources. Our business – and the world’s food security – depend on sustainable natural resources, healthy ecosystems and thriving rural communities. Research and Development (R&D) is the innovation engine of Syngenta and is crucial to driving growth. We want to maintain a high rate of new product delivery to the end of the decade while investing in targeted early research that will deliver breakthrough innovation post-2020. With around 5,000 employees in R&D globally, we continue to search for new and improved ways of raising the quality and yield of crops worldwide. We have a diverse and balanced portfolio of chemicals, genetics and integrated solutions for all our major crops. It is refreshed by constant innovation – to solve new problems and address old problems with new solutions that are more effective, safer or add more value. Complementing our internal resources through partnerships is a key element in our R&D strategy. We strategically collaborate with universities, institutes and companies at the forefront of technology development to solve agricultural challenges. Our Crop Protection research focuses on developing a range of herbicides, fungicides, insecticides and crop enhancing chemicals with broad applicability such as foliar, soil and seed treatments. Our Seeds research & development program focuses on creating new varieties of major field crops, which include improved quality & productivity. This can include greater resistance to pests and diseases, or other environmental stresses, as well as characteristics such as improved customer appeal or enhanced shelf life. In India we aim to get new innovations in the hands of growers to enhance their productivity in key crops like rice, vegetable etc

DIRECTOR (GM), HEAD-CHEMICAL PROFILE GROUP, I&DC-API, FRESENIUS KABI ONCOLOGY LTD, Gurgaon, India

• Jan 2020 - Aug 2022

Fresenius Kabi is a global healthcare company that specializes in lifesaving medicines and technologies for infusion, transfusion and clinical nutrition. Our products and services are used to help care for critically and chronically ill patients. With our corporate philosophy of "caring for life"​, we are committed to putting essential medicines and technologies in the hands of people who help patients and finding the best answers to the challenges they face. Fresenius Kabi employs about… Show more Fresenius Kabi is a global healthcare company that specializes in lifesaving medicines and technologies for infusion, transfusion and clinical nutrition. Our products and services are used to help care for critically and chronically ill patients. With our corporate philosophy of "caring for life"​, we are committed to putting essential medicines and technologies in the hands of people who help patients and finding the best answers to the challenges they face. Fresenius Kabi employs about 35,000 people worldwide. MY JOB RESPONSIBILITIES: Senior Level Assignments in Research & Development or Management with an organization preferably in the Pharmaceutical Industry; Total synthesis and asymmetric synthesis of naturally occurring bioactive and medicinally active compounds. Development of new synthetic routes and methodologies to pharmaceutically important Carbocycles and Heterocycles essential in Drug discovery, API, Process Chemistry, Drug Development, API Process Validation, Feasibility & development, OOS/OOT/OOE investigation of Plant/Manufacturing/Commercial/ICH Batches, Answering queries for Regulatory Agencies (FDA,. EDQM, EMA etc) Fresenius Kabi is a global healthcare company that offers employees of diverse cultures and backgrounds a wide range of fulfilling and challenging career and personal growth opportunities both domestically and internationally. We are committed to putting essential medicines and technologies in the hands of people who help patients and finding the best answers to the challenges they face. We are dedicated to a higher purpose "caring for life"​ which drives excellence in everything we do. We operate with a high level of personal commitment, passion and integrity in a collaborative work environment. Empowerment and strong results orientation are embedded in our culture.

JOINT DIRECTOR, HEAD-IMPURITY GROUP, I&DC-API, FRESENIUS KABI ONCOLOGY LTD, Gurgaon, India

• Jun 2017 - Jan 2020

 Successful Investigation of OOS/OOT/OOE or deviated Plant/Manufacturing/Commercial/ICH/Recalled Batches and Sharing the Study Reports with clients with thorough extensive literature search and efficiency.  Development of APIs right from Route selection to Feasibility to Validation to manufacturing & Marketing across the globe.  Answering Regulatory agency (FDA/EMA/DMF/ANDA/DRL/CRL etc) queries, addressing Plant deviations, Formulation and Process Dev. Lab  Results oriented… Show more  Successful Investigation of OOS/OOT/OOE or deviated Plant/Manufacturing/Commercial/ICH/Recalled Batches and Sharing the Study Reports with clients with thorough extensive literature search and efficiency.  Development of APIs right from Route selection to Feasibility to Validation to manufacturing & Marketing across the globe.  Answering Regulatory agency (FDA/EMA/DMF/ANDA/DRL/CRL etc) queries, addressing Plant deviations, Formulation and Process Dev. Lab  Results oriented Senior Management Executive backed by strong academic credentials and expertise in multi-step Organic Synthesis coupled with extensive experience in routine characterization techniques including FT-1H NMR (1D NMR, 2D NMR experiments), 13C-NMR, DEPT, HSBC, HSQC, FT-IR, OR-measurements, ESI-MS, FAB-MS, GC-MS, LC-MS, HPLC and UV-Vis spectroscopy.  Recognized leadership qualities with experience of developing and leading highly effective and successful work teams; successful track record in managing organizational complexities and business uncertainties. • Troubleshoot all plant-level issues; guide team to provide chemistry expertise to engineering team during scale-up & technical requirements of Production on a daily basis; provide support to QA/QC/Production for critical delivery issues / customer complaints / new customer requirements. • Identifying & development of new products / range of products required in the market, after conducting need analysis/ in response to relevant market survey reports. • Forecasting future needs and hence planning for capacity for production of required quantities of items as per pre-defined standards within financial cost constraints. • Preparing monthly, weekly & daily plans to ensure accomplishment of targets within the specified time and cost parameters. • Extensive experience in extractable/leachable, NDMA, NDEA, NMBA & other genotoxic impurities in Drug Products. • Preparation of impurities for new products under development (support to I&DC sites)

SENIOR PRINCIPAL INVESTIGATOR

• Jul 2012 - May 2017

RESEARCH & DEVELOPMENT • Identifying & development of new products / range of products required in the market, after conducting need analysis/ in response to relevant market survey reports. • Forecasting future needs and hence planning for capacity for production of required quantities of items as per pre-defined standards within financial cost constraints. Preparing monthly, weekly & daily plans to ensure accomplishment of targets within the specified time and cost… Show more RESEARCH & DEVELOPMENT • Identifying & development of new products / range of products required in the market, after conducting need analysis/ in response to relevant market survey reports. • Forecasting future needs and hence planning for capacity for production of required quantities of items as per pre-defined standards within financial cost constraints. Preparing monthly, weekly & daily plans to ensure accomplishment of targets within the specified time and cost parameters. • Conducting online testing of these products & documentation of the process involved and conducting the environment testing & analysis. PROJECT MANAGEMENT • Proficient in drafting various business proposals which includes the small scale Med chem projects, custom chemical synthesis and large manufacturing project proposals • Single point client interface for business growth which includes sending final proposals, negotiating and managing RFI/RFP process in the company. • Proven track record in handling various projects through critical care and time tested project management and ensure on time delivery of the projects. The work includes kick-off meetings, weekly reports, teleconferences, Receivable management, proposing contingent plans and closure meetings. • To establish E-lab notebooks in the Team • To establish processes (SOP and WI) of Team w.r.t. way of working (covering synthesis and preparative isolation), dealing with different customers in consultation with analytical teams etc • Conducting online testing of these products & documentation of the process involved and conducting the environment testing & analysis. • Monitor and guide the team through ideation to developing Proof of Concept; study the reproducibility of the lab process in the plant and finalize process after validation; monitor & review. • Conducting online testing of these products & documentation of the process involved and conducting the environment testing & analysis. • Preparing monthly, weekly & daily plans. Show less RESEARCH & DEVELOPMENT • Identifying & development of new products / range of products required in the market, after conducting need analysis/ in response to relevant market survey reports. • Forecasting future needs and hence planning for capacity for production of required quantities of items as per pre-defined standards within financial cost constraints. Preparing monthly, weekly & daily plans to ensure accomplishment of targets within the specified time and cost… Show more RESEARCH & DEVELOPMENT • Identifying & development of new products / range of products required in the market, after conducting need analysis/ in response to relevant market survey reports. • Forecasting future needs and hence planning for capacity for production of required quantities of items as per pre-defined standards within financial cost constraints. Preparing monthly, weekly & daily plans to ensure accomplishment of targets within the specified time and cost parameters. • Conducting online testing of these products & documentation of the process involved and conducting the environment testing & analysis. PROJECT MANAGEMENT • Proficient in drafting various business proposals which includes the small scale Med chem projects, custom chemical synthesis and large manufacturing project proposals • Single point client interface for business growth which includes sending final proposals, negotiating and managing RFI/RFP process in the company. • Proven track record in handling various projects through critical care and time tested project management and ensure on time delivery of the projects. The work includes kick-off meetings, weekly reports, teleconferences, Receivable management, proposing contingent plans and closure meetings. • To establish E-lab notebooks in the Team • To establish processes (SOP and WI) of Team w.r.t. way of working (covering synthesis and preparative isolation), dealing with different customers in consultation with analytical teams etc • Conducting online testing of these products & documentation of the process involved and conducting the environment testing & analysis. • Monitor and guide the team through ideation to developing Proof of Concept; study the reproducibility of the lab process in the plant and finalize process after validation; monitor & review. • Conducting online testing of these products & documentation of the process involved and conducting the environment testing & analysis. • Preparing monthly, weekly & daily plans. Show less

Senior Research Investigator

• Mar 2010 - Jun 2012

• Strong competency in the synthetic organic/medicinal chemistry and Combinatorial Chemistry. • Mentoring variety of synthetic methods, especially in heterocyclic chemistry. • Monitoring synthesis in medicinal chemistry lead optimization. • Full understanding of mechanistic details, scale up and/or process chemistry. • Experience in leading a team in a drug discovery environment with an appreciation of medicinal chemistry. • Able to present/articulate to large internal/external… Show more • Strong competency in the synthetic organic/medicinal chemistry and Combinatorial Chemistry. • Mentoring variety of synthetic methods, especially in heterocyclic chemistry. • Monitoring synthesis in medicinal chemistry lead optimization. • Full understanding of mechanistic details, scale up and/or process chemistry. • Experience in leading a team in a drug discovery environment with an appreciation of medicinal chemistry. • Able to present/articulate to large internal/external groups • Having very strong judgment; and exhibit tactful discretion. • Having analytical thinking and problem solving skills. • Able to make high level decisions. • Able to build a team in a short span of time. • Have hands-on experience in design, development, scale-up and troubleshooting of synthetic chemistry process from laboratory reactors to pilot or production tanks. • Experience in the resolution of technical problems during manufacturing. • Heading the synthetic group, overall responsible for the operations of the synthetic lab and its manufacturing facility, in a service-oriented, contract manufacturing mode. • Co-ordinate with QA/QC and drive all quality initiatives. Ensure compliance with quality guidelines / procedures • Strong Project Management skills with expertise influencing key decision makers within a matrix environment. • Expert knowledge of synthetic and medicinal chemistry and proven track record in leading synthetic operations and successful regulatory/client inspections. • Responsible for budgetary planning and monitoring. Show less • Strong competency in the synthetic organic/medicinal chemistry and Combinatorial Chemistry. • Mentoring variety of synthetic methods, especially in heterocyclic chemistry. • Monitoring synthesis in medicinal chemistry lead optimization. • Full understanding of mechanistic details, scale up and/or process chemistry. • Experience in leading a team in a drug discovery environment with an appreciation of medicinal chemistry. • Able to present/articulate to large internal/external… Show more • Strong competency in the synthetic organic/medicinal chemistry and Combinatorial Chemistry. • Mentoring variety of synthetic methods, especially in heterocyclic chemistry. • Monitoring synthesis in medicinal chemistry lead optimization. • Full understanding of mechanistic details, scale up and/or process chemistry. • Experience in leading a team in a drug discovery environment with an appreciation of medicinal chemistry. • Able to present/articulate to large internal/external groups • Having very strong judgment; and exhibit tactful discretion. • Having analytical thinking and problem solving skills. • Able to make high level decisions. • Able to build a team in a short span of time. • Have hands-on experience in design, development, scale-up and troubleshooting of synthetic chemistry process from laboratory reactors to pilot or production tanks. • Experience in the resolution of technical problems during manufacturing. • Heading the synthetic group, overall responsible for the operations of the synthetic lab and its manufacturing facility, in a service-oriented, contract manufacturing mode. • Co-ordinate with QA/QC and drive all quality initiatives. Ensure compliance with quality guidelines / procedures • Strong Project Management skills with expertise influencing key decision makers within a matrix environment. • Expert knowledge of synthetic and medicinal chemistry and proven track record in leading synthetic operations and successful regulatory/client inspections. • Responsible for budgetary planning and monitoring. Show less

GROUP LEADER

• Oct 2008 - Feb 2010

Evotec India Ltd. is a Germany based pharmaceutical MNC and today is having contracts with global pharmaceutical companies for the synthesis and supply of compound libraries. It uses skills and expertise in parallel synthesis, purification and analysis to synthesize and purify hit discovery libraries of hundreds to thousands of high quality compounds in the format specified by the customer. RESPOSIBILITIES Undertaken: • Actively involved in conducting high throughput synthesis of lead… Show more Evotec India Ltd. is a Germany based pharmaceutical MNC and today is having contracts with global pharmaceutical companies for the synthesis and supply of compound libraries. It uses skills and expertise in parallel synthesis, purification and analysis to synthesize and purify hit discovery libraries of hundreds to thousands of high quality compounds in the format specified by the customer. RESPOSIBILITIES Undertaken: • Actively involved in conducting high throughput synthesis of lead finding libraries, parallel synthesis of focused libraries as per customer requirements and automated purification of compound libraries. • Ensure all libraries are formatted as per customer requirements including plates / tubes / vials and provide access to validated chemistries for library synthesis • Acquired thorough expertise in the state-of-the-art equipment for high throughput synthesis and analysis as well as Library design and profiling. • Provide cost effective solutions and ensure seamless communication with the customers with respect to deliverables and business terms • Successfully handle Automated Liquid & Plate (Cyberlab, Anachem), High Throughput Liquid (Zinsser Lissy), High Throughput Solid (Zinsser REDI), Prep HPLC (Waters), Multiprobe (Perkin Elmer), High Throughput Vial Weighing System (Labman), Automated Parallel LC/MS (Waters) and High Throughput Evaporators (Genevac). Show less Evotec India Ltd. is a Germany based pharmaceutical MNC and today is having contracts with global pharmaceutical companies for the synthesis and supply of compound libraries. It uses skills and expertise in parallel synthesis, purification and analysis to synthesize and purify hit discovery libraries of hundreds to thousands of high quality compounds in the format specified by the customer. RESPOSIBILITIES Undertaken: • Actively involved in conducting high throughput synthesis of lead… Show more Evotec India Ltd. is a Germany based pharmaceutical MNC and today is having contracts with global pharmaceutical companies for the synthesis and supply of compound libraries. It uses skills and expertise in parallel synthesis, purification and analysis to synthesize and purify hit discovery libraries of hundreds to thousands of high quality compounds in the format specified by the customer. RESPOSIBILITIES Undertaken: • Actively involved in conducting high throughput synthesis of lead finding libraries, parallel synthesis of focused libraries as per customer requirements and automated purification of compound libraries. • Ensure all libraries are formatted as per customer requirements including plates / tubes / vials and provide access to validated chemistries for library synthesis • Acquired thorough expertise in the state-of-the-art equipment for high throughput synthesis and analysis as well as Library design and profiling. • Provide cost effective solutions and ensure seamless communication with the customers with respect to deliverables and business terms • Successfully handle Automated Liquid & Plate (Cyberlab, Anachem), High Throughput Liquid (Zinsser Lissy), High Throughput Solid (Zinsser REDI), Prep HPLC (Waters), Multiprobe (Perkin Elmer), High Throughput Vial Weighing System (Labman), Automated Parallel LC/MS (Waters) and High Throughput Evaporators (Genevac). Show less

SENIOR SCIENTIFIC MANAGER

• Mar 2007 - Sep 2008

Senior Scientist (Manager) Medicinal Chemistry Division • Entrusted with the responsibility to manage and lead the team of 10 Chemists for executing projects for Clients of USA (AstraZeneca, USA) and UK (GSK, UK). • Actively involved in managing and steering ~30 ongoing projects and prepared project proposals, scientific reports and presentations. • Collaborated with the clients regularly to apprise them of the daily progress of the project and weekly reports through… Show more Senior Scientist (Manager) Medicinal Chemistry Division • Entrusted with the responsibility to manage and lead the team of 10 Chemists for executing projects for Clients of USA (AstraZeneca, USA) and UK (GSK, UK). • Actively involved in managing and steering ~30 ongoing projects and prepared project proposals, scientific reports and presentations. • Collaborated with the clients regularly to apprise them of the daily progress of the project and weekly reports through Teleconferences. • Independently planned and performed experiments and accountable for literature collection & identify suitable reaction conditions. • Analyzed the spectral data and undertook decisions accordingly with respect to projects. • Deftly trained, educated and guided the team members in scientific, technical skills and subject concepts and ensured judicious allocation of tasks. • Played an important role in executing HR functions too such as performance appraisals of the Group and career development. Show less Senior Scientist (Manager) Medicinal Chemistry Division • Entrusted with the responsibility to manage and lead the team of 10 Chemists for executing projects for Clients of USA (AstraZeneca, USA) and UK (GSK, UK). • Actively involved in managing and steering ~30 ongoing projects and prepared project proposals, scientific reports and presentations. • Collaborated with the clients regularly to apprise them of the daily progress of the project and weekly reports through… Show more Senior Scientist (Manager) Medicinal Chemistry Division • Entrusted with the responsibility to manage and lead the team of 10 Chemists for executing projects for Clients of USA (AstraZeneca, USA) and UK (GSK, UK). • Actively involved in managing and steering ~30 ongoing projects and prepared project proposals, scientific reports and presentations. • Collaborated with the clients regularly to apprise them of the daily progress of the project and weekly reports through Teleconferences. • Independently planned and performed experiments and accountable for literature collection & identify suitable reaction conditions. • Analyzed the spectral data and undertook decisions accordingly with respect to projects. • Deftly trained, educated and guided the team members in scientific, technical skills and subject concepts and ensured judicious allocation of tasks. • Played an important role in executing HR functions too such as performance appraisals of the Group and career development. Show less

Post Doctoral Researcher

• Dec 2004 - Mar 2007

• Asymmetric Total Synthesis and SAR Studies of Salinosporamide A : A Proteasome Inhibitor and a Cytotoxic Natural Product: The recently isolated marine natural product, Salinosporamide A, was found to be a very efficient and selective inhibitor of proteasome and also exhibited highly potent anticancer activity against a variety of human cancer cell lines. Because of its recent discovery, very little information is available about the structural parameters that impart the observed… Show more • Asymmetric Total Synthesis and SAR Studies of Salinosporamide A : A Proteasome Inhibitor and a Cytotoxic Natural Product: The recently isolated marine natural product, Salinosporamide A, was found to be a very efficient and selective inhibitor of proteasome and also exhibited highly potent anticancer activity against a variety of human cancer cell lines. Because of its recent discovery, very little information is available about the structural parameters that impart the observed biological activity to Salinosporamide A. Therefore, in present research, a total synthetic route to this molecule and its subsequent application towards detailed structure-activity relationship investigations has been initiated. My present research is focused on the total synthesis, detailed structure-activity relationship and development of more potent analogs based on the natural product lead. In studies so far, we have able to develop a novel and efficient synthetic route to an enantiopure pyrrolodin-2-one structural core, containing strategically located functionalities that are expected to allow further synthetic transformations, towards synthesizing the desired natural product and various analogs thereof. It is expected that results from this research will provide a better understanding of what imparts anticancer activity to Salinosporamide A and help to realize the high promise on this unique compound in its ultimate development as a potent anticancer therapeutic agent. Show less • Asymmetric Total Synthesis and SAR Studies of Salinosporamide A : A Proteasome Inhibitor and a Cytotoxic Natural Product: The recently isolated marine natural product, Salinosporamide A, was found to be a very efficient and selective inhibitor of proteasome and also exhibited highly potent anticancer activity against a variety of human cancer cell lines. Because of its recent discovery, very little information is available about the structural parameters that impart the observed… Show more • Asymmetric Total Synthesis and SAR Studies of Salinosporamide A : A Proteasome Inhibitor and a Cytotoxic Natural Product: The recently isolated marine natural product, Salinosporamide A, was found to be a very efficient and selective inhibitor of proteasome and also exhibited highly potent anticancer activity against a variety of human cancer cell lines. Because of its recent discovery, very little information is available about the structural parameters that impart the observed biological activity to Salinosporamide A. Therefore, in present research, a total synthetic route to this molecule and its subsequent application towards detailed structure-activity relationship investigations has been initiated. My present research is focused on the total synthesis, detailed structure-activity relationship and development of more potent analogs based on the natural product lead. In studies so far, we have able to develop a novel and efficient synthetic route to an enantiopure pyrrolodin-2-one structural core, containing strategically located functionalities that are expected to allow further synthetic transformations, towards synthesizing the desired natural product and various analogs thereof. It is expected that results from this research will provide a better understanding of what imparts anticancer activity to Salinosporamide A and help to realize the high promise on this unique compound in its ultimate development as a potent anticancer therapeutic agent. Show less