Experience

Morphic Therapeutic

• United States
• Pharmaceutical Manufacturing
• 1 - 100 Employee

• Director

  • Jan 2023 - Present

  - MIDD (Model-Informed Drug Development) - PK and PK/PD Modeling and Simulations

• Associate Director

  • Jan 2021 - Dec 2022

  -MIDD (Model-Informed Drug Development)

• Principal Scientist

  • Jan 2019 - Dec 2020

  - Modeling & Simulatons in DMPK



Applied BioMath

• United States
• Biotechnology Research
• 1 - 100 Employee

• Senior Scientist

  • Feb 2016 - Jan 2019

  - Mechanism-based Pharmacokinetics and Pharmacodynamics Modeling & Simulations - Quantitative and Systems Pharmacology Modeling & Simulations - Mechanism-based Pharmacokinetics and Pharmacodynamics Modeling & Simulations - Quantitative and Systems Pharmacology Modeling & Simulations



FORUM Pharmaceuticals

• Biotechnology Research
• 1 - 100 Employee

• Scientist

  • Jul 2015 - Jan 2016

  - Modeling and Simulation Scientist in DMPK • PK/PD, PBPK (Physiologically-based PK) and QSP (Quantitative Systems Pharmacology) modeling in neurodegenerative diseases. • Phoenix WinNonlin/NLME, Berkeley Madonna, MATLAB SimBiology, JDesigner, Cell Designer (SBML), R, Fortran, C++, Mac OS Xcode. - Modeling and Simulation Scientist in DMPK • PK/PD, PBPK (Physiologically-based PK) and QSP (Quantitative Systems Pharmacology) modeling in neurodegenerative diseases. • Phoenix WinNonlin/NLME, Berkeley Madonna, MATLAB SimBiology, JDesigner, Cell Designer (SBML), R, Fortran, C++, Mac OS Xcode.



Pfizer

• United States
• Pharmaceutical Manufacturing
• 700 & Above Employee

• Postdoctoral Fellow - Systems Pharmacology Modeling & Simulations, PharmaTherapeutics Clinical R&D

  • Nov 2013 - Jul 2015

  - PharmaTherapeutics Clinical Research (formerly BioTherapeutics Clinical R&D) / PharmaTherapeutics R&D / Worldwide R&D • Building a quantitative systems pharmacology model of blood coagulation network to support dose selection and novel clinical endpoints identification. - PharmaTherapeutics Clinical Research (formerly BioTherapeutics Clinical R&D) / PharmaTherapeutics R&D / Worldwide R&D • Building a quantitative systems pharmacology model of blood coagulation network to support dose selection and novel clinical endpoints identification.



University of Pennsylvania

• United States
• Higher Education
• 700 & Above Employee

• Research Associate

  • Mar 2013 - Oct 2013

  - Daniel Hammer Lab (Bioengineering) • Designed and implemented multi-parametric global and local sensitivity analysis of Integrated-Signaling Adhesive Dynamics computational model to identify key components and signaling pathways in T lymphocyte recruitment under shear providing the potential targets for further experimental analyses and for auto-immunological disorders.

• Postdoctoral fellow

  • Mar 2008 - Feb 2013

  - Daniel Hammer Lab (Bioengineering) - American Heart Association Postdoctoral Fellowship, July 2009-June 2011 • Utilized integrative approaches that combined flow chamber experiments with computational modeling to illustrate the modulating role of diacylglycerol kinase zeta in T lymphocyte homing under shear flow allowing better understanding of pathological inflammatory response of T cells for potential new anti-inflammation drug targets. • Discovered a crucial role of SLP-76… Show more - Daniel Hammer Lab (Bioengineering) - American Heart Association Postdoctoral Fellowship, July 2009-June 2011 • Utilized integrative approaches that combined flow chamber experiments with computational modeling to illustrate the modulating role of diacylglycerol kinase zeta in T lymphocyte homing under shear flow allowing better understanding of pathological inflammatory response of T cells for potential new anti-inflammation drug targets. • Discovered a crucial role of SLP-76 intracellular protein in T lymphocyte recruitment in hydrodynamic flow allowing a new approach to modulate integrin signaling against auto-immune disorders. • Built T lymphocyte homing state maps showing the regulation of ultimate position of navigating T lymphocytes by the array of receptors host tissues express and chemokines T lymphocytes encounter in hydrodynamic flow. • Utilized reflection interference contrast microscopy to reveal the differential regulation of the contact and spreading dynamics of genetically-modified murine platelets providing important quantitative insights for the understanding of hemostasis and thrombosis.



University of Rochester

• United States
• Higher Education
• 700 & Above Employee

• Postdoctoral fellow

  • Jan 2008 - Feb 2008

  - Michael King Lab (Biomedical Engineering) • Explored the simultaneous activation of integrin receptors on neutrophils during mechanical shedding of L-selectin providing a new insight into immune cell activation pathway

• Ph.D. Graduate Research Assistant

  • Sep 2002 - Dec 2007

  - Michael King Lab (Chemical Engineering; Biomedical Engineering) • Built a biophysical model through computational simulations explaining the shear threshold effect in L-selectin-mediated neutrophil rolling providing a biophysical insight into the correlation between force-dependent molecular dissociation and immune cell dynamics • Found a novel mechanism of L-selectin shedding from the neutrophil surface under hydrodynamic shear • Built a computational model to explain the… Show more - Michael King Lab (Chemical Engineering; Biomedical Engineering) • Built a biophysical model through computational simulations explaining the shear threshold effect in L-selectin-mediated neutrophil rolling providing a biophysical insight into the correlation between force-dependent molecular dissociation and immune cell dynamics • Found a novel mechanism of L-selectin shedding from the neutrophil surface under hydrodynamic shear • Built a computational model to explain the mechanical shedding of L-selectin during leukocyte rolling • Explained the mechanism of L-selectin redistribution on the leukocyte membrane during inflammation process using in silico and in vitro analysis • Discovered the enhancement of cell rolling by controlling adhesion ligand orientation providing the potential for the future development of devices for isolating specific cell types from blood • Assessed the dynamics of leukocytes in controlled microbubble arrays under shear providing the potentials for microfluidic cell sorting and microcell culture



Yonsei University

• South Korea
• Higher Education
• 700 & Above Employee

• Research Associate

  • Feb 2002 - Jun 2002

  - Han-Sung Jung Lab (Oral Biology Laboratory in the College of Dentistry) • Explored engineering methods to induce the differentiation of embryonic stem cells into an artificial tooth - Han-Sung Jung Lab (Oral Biology Laboratory in the College of Dentistry) • Explored engineering methods to induce the differentiation of embryonic stem cells into an artificial tooth



Korea University

• Seongbuk-gu, Seoul, Korea

• M.S. Graduate Research Assistant

  • Sep 1999 - Aug 2001

  - Ik-Hwan Kim Lab (Cell Culture Engineering Laboratory in the School of Biotechnology) • Developed an engineering method to decrease toxic by-products during large-scale CHO cell culture for producing biopharmaceutical products such as recombinant human EPO - Ik-Hwan Kim Lab (Cell Culture Engineering Laboratory in the School of Biotechnology) • Developed an engineering method to decrease toxic by-products during large-scale CHO cell culture for producing biopharmaceutical products such as recombinant human EPO