Experience

Larodan AB

• Sweden
• Chemical Manufacturing
• 1 - 100 Employee

• Senior Chemist

  • Oct 2019 - Present

  Development and synthesis of various lipids, including fatty acids, phospholipids, 2- and 3-monochloropropane-1,2-diols (2- and 3-MCPDs) and their esters, glycidyl esters, glycerides, and other lipid related compoundsDevelopment of methodology for the preparation of stable isotope labeled unsaturated fatty acids, and 2- and 3-MCPDsChemoenzymatic synthesis of phospholipidsSynthesis of unusual fatty acids Development and synthesis of various lipids, including fatty acids, phospholipids, 2- and 3-monochloropropane-1,2-diols (2- and 3-MCPDs) and their esters, glycidyl esters, glycerides, and other lipid related compoundsDevelopment of methodology for the preparation of stable isotope labeled unsaturated fatty acids, and 2- and 3-MCPDsChemoenzymatic synthesis of phospholipidsSynthesis of unusual fatty acids



Karolinska Institutet

• Sweden
• Higher Education
• 700 & Above Employee

• Senior Researcher

  • Jul 2018 - Present

  Development of novel synthetic oligonucleotides and oligonucleotide conjugates for cellular uptake and targeted delivery - Design and synthesis of novel chemically modified oligonucleotides and oligonucleotide‒peptide conjugates for improved treatment of Duchenne Muscular Dystrophy (DMD) - Development of methodology for the synthesis of novel modified nucleosides and nucleotides with methylated pyrimidine bases - Design and synthesis of oligonucleotide‒small molecule mono- and multi-conjugates for the selection of protein binders (Multivalent SNAP Display)

• Assistant Professor

  • Jul 2014 - Jun 2018

  Development of novel modified oligonucleotides and oligonucleotide-peptide conjugates for efficient cellular uptake - Development of methodology and synthesis of fully and partially modified oligonucleotides, and oligonucleotide gapmers in combination with novel 2'-O-AECM (2'-O-aminoethylcarbamoyl), 2'-OMe modifications, and phosphodiester (PO), phosphorothioate (PS) or mixed (PO/PS) backbone - Preparation of oligonucleotide-peptide conjugates - Bioconjugation using Cu catalyzed click chemistry - Development of linkers for conjugation of oligonucleotides with peptides or other moieties - Design and execution of research project for Moderna Therapeutics (2 year project timeline)

• Researcher

  • May 2012 - Jun 2014

  Development of synthetic oligonucleotides for efficient cellular uptake and stability against nucleases - Development of methodology and synthesis of purine and pyrimidine nucleosides and nucleotides containing novel AECM modification - Development of methodology and synthesis of partially and fully AECM-modified oligonucleotides - Preparation of labelled oligonucleotides, e.g., with fluorescein, cholesterol - Enzymatic studies on stability of synthetic oligonucleotides - Establishing collaboration with drug development company Syntagon Baltic SIA, Latvia for the large scale preparation of AECM-modified nucleoside building blocksDesign and development of second-generation peptidomimetics for potential treatment/prevention of Alzheimer’s disease - Development of triamino acid building blocks with different lipophilicities - Design and synthesis of second-generation ligands for targeting amyloid-β peptide - Development of new fluorescent D-amino acids

• Postdoctoral Researcher

  • May 2010 - Apr 2012

  - Initial work on methodology for the preparation of novel AECM-modified pyrimidine nucleoside - Development of methodology and synthesis of novel unnatural triamino acids - Design and synthesis of peptide-like ligands in solution for targeting amyloid-β peptide - Solid-phase synthesis of ligands utilizing Fmoc chemistry



University of Cambridge

• United Kingdom
• Research Services
• 700 & Above Employee

• Research Associate

  • Apr 2019 - Jun 2019

  SNAP Display for the selection of protein bindersDevelopment of multivalent benzylguanine-DNA constructs SNAP Display for the selection of protein bindersDevelopment of multivalent benzylguanine-DNA constructs



ModPro AB

• Sweden
• Biotechnology Research

• Scientist

  • Aug 2008 - Apr 2010

  Development of polypeptide conjugate binders for molecular recognition Chemistry Lead in projects - Design and synthesis of small organic molecules and their derivatization for conjugation with peptides - Solid-phase peptide synthesis - Post-synthetic modification of peptides and preparation of peptide-small molecule conjugates - Orthogonal protection in peptide chemistry - Conjugation of peptides and small molecules utilizing pentafluorophenyl/p-nitrophenyl active ester, NHS ester and maleimide chemistry



Uppsala University

• Sweden
• Higher Education
• 700 & Above Employee

• Postdoctoral Researcher

  • Aug 2008 - Apr 2010

  Development of polypeptide‒small synthetic molecule conjugates for molecular recognitionWork on the new assay design for clinical diagnostics based on alternative recognition elements Development of polypeptide‒small synthetic molecule conjugates for molecular recognitionWork on the new assay design for clinical diagnostics based on alternative recognition elements