Experience

Accelero Biostructures

• United States
• Biotechnology Research
• 1 - 100 Employee

• Co-Founder & Chief Executive Officer

  • Jan 2015 - 9 years

  San Francisco, CA I boot-strapped our company to a self-sustaining, revenue generating and profitable entity in our second year working with multiple pharma and biotech companies and academic drug discovery as well as SBIR (Phase I & II) R&D, raising ~$2.5M in non-dilutive funding. I am involved in business and technology development and deployment for high-throughput protein x-ray crystallography-driven drug discovery and development of fragment- and structure-based drug discovery programs.



XPose Therapeutics

• United States
• Research
• 1 - 100 Employee

• Co-Founder

  • Jul 2019 - 4 years 6 months



AN2H Discovery

• Scientist, Structure-Based Drug Discovery

  • Nov 2015 - Nov 2016

  Structure-based drug discovery in neuroscience and oncology of key proteins in the Ubiquitin Proteasome System (UPS) targeting protein degradation and turnover mechanisms for therapeutics development.



SLAC National Accelerator Laboratory

• United States
• Research Services
• 700 & Above Employee

• Staff Scientist, JCSG (Joint Center for Structural Genomics)

  • Apr 2007 - Feb 2015

  PSI Biology Network Center for High-throughput Protein X-ray Crystallography. Structural biologist and protein crystallographer in a High-Throughput Structural Biology Gene to Structure pipeline that resulted in more than 1400 novel protein structures. Personally worked on ~150 novel structures and analysis and Quality Control on another ~150. Initiated and managed more than 10 key external partnerships resulting in publications for over 50%. Experienced in… Show more PSI Biology Network Center for High-throughput Protein X-ray Crystallography. Structural biologist and protein crystallographer in a High-Throughput Structural Biology Gene to Structure pipeline that resulted in more than 1400 novel protein structures. Personally worked on ~150 novel structures and analysis and Quality Control on another ~150. Initiated and managed more than 10 key external partnerships resulting in publications for over 50%. Experienced in technology adoption and integration of hardware automation, biophysical and computational protocols into the high-throughput pipeline that led to integration of small-angle x-ray scattering into pipeline and a bioinformatics analysis pipeline for an entire protein family. Show less



Stanford University

• United States
• Higher Education
• 700 & Above Employee

• Staff Scientist (SLAC National Accelerator Laboratory)

  • Apr 2007 - Feb 2015



Berkeley Lab

• United States
• Research Services
• 700 & Above Employee

• Postdoctoral Scientist

  • Mar 2004 - Mar 2007

  Berkeley Structural Genomics Center High-throughput Protein X-ray Structure Determination/Structural Biology Postdoctoral Research at LBL/UC Berkeley In the research group of Prof. Sung-Hou Kim and as part of the Berkeley Structural Genomics Center Designed and implemented a rapid protocol for detergent screening in the solubilization, purification and crystallization of membrane proteins that resulted in parallel screening of multiple targets with 18 detergents in ~72 hours, saving time by ~90% with associated cost… Show more High-throughput Protein X-ray Structure Determination/Structural Biology Postdoctoral Research at LBL/UC Berkeley In the research group of Prof. Sung-Hou Kim and as part of the Berkeley Structural Genomics Center Designed and implemented a rapid protocol for detergent screening in the solubilization, purification and crystallization of membrane proteins that resulted in parallel screening of multiple targets with 18 detergents in ~72 hours, saving time by ~90% with associated cost savings of scientific and technical effort. Developed structural biology projects involving several stem cell related proteins and GPCRs including target selection as well as cloning, expression and purification for several proteins. Led to production and initial characterization of several stem cell transcription factors and GPCRs, thereby setting the stage for further work on these proteins. X-ray crystallography studies on bacterial integral mebrane proteins involved in signaling and drug transport resulting in the crystal structure of the multi-drug efflux transporter AcrB, which revealed possible mechanism of drug recognition and transport out of the cytoplasm. Show less



Indiana University School of Medicine

• Research Services
• 700 & Above Employee

• Visting Research Associate (Visiting Graduate Student)

  • Aug 2002 - Feb 2004

  Completing research for doctoral thesis, in the research group of Prof. Millie Georgiadis.



Rutgers University

• United States
• Higher Education
• 700 & Above Employee

• PhD student

  • 1998 - 2004

  Crystal structure determination of the complete RT (Reverse Transcriptase) from murine leukemia virus (MMLV), in the research group of Prof. Millie Georgiadis. X-ray crystallography studies of the full-length MMLV RT revealed for the first time the architecture of the mouse form of the enzyme that is the primary target for anti-AIDS therapies, thereby providing a second system for comparative structural studies to get a better insight into the structure-function relationships in this… Show more Crystal structure determination of the complete RT (Reverse Transcriptase) from murine leukemia virus (MMLV), in the research group of Prof. Millie Georgiadis. X-ray crystallography studies of the full-length MMLV RT revealed for the first time the architecture of the mouse form of the enzyme that is the primary target for anti-AIDS therapies, thereby providing a second system for comparative structural studies to get a better insight into the structure-function relationships in this protein. Protein engineering of MMLV RT to enhance solubility for large-scale purification and crystallization led to the ability to crystallize the protein-DNA complex and enable structure determination by x-ray crystallography. Show less