David Fraebel
Senior Scientist at Fluid-Screen- Claim this Profile
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Experience
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Fluid-Screen
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United States
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Nanotechnology Research
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1 - 100 Employee
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Senior Scientist
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Sep 2022 - Present
● Developed experimental methods and data analysis techniques for real-time microbial detection system● Characterized two critical technical hurdles with existing method● Demonstrated feasibility of major protocol simplification to eliminate those issues while also reducing cost, labor requirements and barrier to entry for new users● Interpreted USP/PDA validation framework in the context of our technology, turned this understanding into an actionable plan, and demonstrated system’s unlocked capability for single cell detection● Coordinated actions for effective small team projects
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Research Scientist IV
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Aug 2021 - Sep 2022
● Designed and executed experimental studies to answer scientific questions critical to product development and customer applications● Leveraged findings to identify and implement data-driven improvements to products and processes● Quantified the dependence of microbial capture on fluidic, electrical, and biological variables● Optimized experimental and analysis techniques to reduce false results● Built patent pending computer vision application for bacterial quantification and robust framework for its optimization and generalization● Contributed to multiple patent applications
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Research Scientist
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Jul 2020 - Aug 2021
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University of Illinois at Urbana-Champaign
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Higher Education
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1 - 100 Employee
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Graduate Research Assistant
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Aug 2013 - Dec 2019
April 2014 - December 2019: Seppe Kuehn Lab (PhD project) ● Designed and executed novel experimental evolution study which used multidimensional selective pressure over hundreds of generations to reveal evolutionary trade-offs and adaptive phenotypic plasticity in E. coli ● Optimized high throughput measurements of bacterial motility and growth phenotypes and developed customized MATLAB software to extract statistical insight from large data sets ● Prepared, sequenced and analyzed hundreds of NGS libraries to characterize novel mutations ● Engineered mutant E. coli strains via point mutation and gene knockout to reveal genotype-phenotype map ● Simulated a reaction-diffusion model to connect population level adaptation to changes in single-cell traits ● Constructed custom low cost devices for automated measurement of migrating bacterial populations December 2013 - April 2014: Thomas Kuhlman Lab (Rotation) ● Quantified growth state dependent changes in gene locus motion with fluorescence microscopy and automated image segmentation August - November 2013: Paul Selvin Lab (Rotation) ● Examined motor protein activity in vivo with neuronal transfection and fluorescence microscopy
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Carnegie Mellon University
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United States
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Higher Education
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700 & Above Employee
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Undergraduate Researcher
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May 2011 - May 2013
Mathias Lösche Lab (CMU Physics) ● Confirmed specificity of lipid-protein interaction with surface plasmon resonance real-time in vitro binding assay ● Prepared solid-supported lipid bilayer membranes and verified robustness with electrochemical impedance spectroscopy Mathias Lösche Lab (CMU Physics) ● Confirmed specificity of lipid-protein interaction with surface plasmon resonance real-time in vitro binding assay ● Prepared solid-supported lipid bilayer membranes and verified robustness with electrochemical impedance spectroscopy
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University of Kentucky
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United States
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Higher Education
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700 & Above Employee
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Undergraduate Researcher
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May 2010 - Aug 2010
Francisco Andrade Lab (UK Physiology) ● Constructed system for in vitro fatiguing of muscles and digital measurement of response Francisco Andrade Lab (UK Physiology) ● Constructed system for in vitro fatiguing of muscles and digital measurement of response
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Education
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University of Illinois at Urbana-Champaign
Doctor of Philosophy - PhD, Physics -
Carnegie Mellon University
Bachelor of Science - BS, Physics