Experience

OmniAb, Inc.

• United States
• Biotechnology Research
• 1 - 100 Employee

• Senior Manager, Modeling and Computational Design

  • Oct 2023 - Present

  Tucson, Arizona, United States Omniab, Inc - In Silico Discovery Center

• Principal Scientist

  • Nov 2022 - Oct 2023

  Tucson, Arizona, United States Omniab, Inc - In Silico Discovery Center



Icagen

• United States
• Biotechnology Research
• 1 - 100 Employee

• Principal Scientist

  • Feb 2021 - Nov 2022

  Tucson, Arizona, United States

• Senior Research Scientist

  • Apr 2017 - Feb 2021

  Tucson, Arizona Area



University of North Carolina at Chapel Hill

• United States
• Higher Education
• 700 & Above Employee

• Postdoctoral Researcher

  • Nov 2014 - Mar 2017

  Raleigh-Durham, North Carolina Area • Performed molecular dynamics simulations of wild type and mutant ryanodine receptors to assess structural perturbations of mutations. • Designed mutations to increase the catalytic activity of novel enzymes hydrolyzing organophosphate nerve agents using molecular dynamics simulations in conjunction with free energy and docking calculations. • Performed protein folding calculations using replica exchange discreet molecular dynamics simulations to determine effects of folding mutants on… Show more • Performed molecular dynamics simulations of wild type and mutant ryanodine receptors to assess structural perturbations of mutations. • Designed mutations to increase the catalytic activity of novel enzymes hydrolyzing organophosphate nerve agents using molecular dynamics simulations in conjunction with free energy and docking calculations. • Performed protein folding calculations using replica exchange discreet molecular dynamics simulations to determine effects of folding mutants on the NBD1 domain of the Cystic fibrosis transmembrane conductance regulator. Show less



University of Pittsburgh School of Medicine

• United States
• Higher Education
• 700 & Above Employee

• Postdoctoral Researcher

  • May 2014 - Oct 2014

  Greater Pittsburgh Area • Performed molecular dynamics simulations implementing NMR restraints in GROMACs to obtain structural models for a nicotinic acetylcholine receptor transmembrane domain. • Analyzed NMR titration data and 2D NMR saturation transfer experiments to identify binding sites of positive allosteric modulators (PAMs) of therapeutic interest. • Performed two electrode voltage clamp (TEVC) electrophysiology experiments for functional validation of proposed PAM binding sites. • Trained other… Show more • Performed molecular dynamics simulations implementing NMR restraints in GROMACs to obtain structural models for a nicotinic acetylcholine receptor transmembrane domain. • Analyzed NMR titration data and 2D NMR saturation transfer experiments to identify binding sites of positive allosteric modulators (PAMs) of therapeutic interest. • Performed two electrode voltage clamp (TEVC) electrophysiology experiments for functional validation of proposed PAM binding sites. • Trained other members of the lab to perform molecular docking using AutoDock and perform molecular dynamics experiments using GROMACs Show less



University of Pittsburgh

• United States
• Higher Education
• 700 & Above Employee

• Graduate Student

  • Aug 2008 - May 2014

  Greater Pittsburgh Area Examining Anesthetic Effects on nicotinic acetylcholine receptors using both computational and experimental approaches • Performed molecular dynamics simulations in conjunction with normal mode analyses to determine drug-induced changes to ion channel dynamics • Drug screening on experimental structures of ion channels using Open Eye software to identify novel therapeutic modulators. • Developed a modified Cyana annealing algorithm for the purpose of NMR… Show more Examining Anesthetic Effects on nicotinic acetylcholine receptors using both computational and experimental approaches • Performed molecular dynamics simulations in conjunction with normal mode analyses to determine drug-induced changes to ion channel dynamics • Drug screening on experimental structures of ion channels using Open Eye software to identify novel therapeutic modulators. • Developed a modified Cyana annealing algorithm for the purpose of NMR structure refinement in order to improve NMR structures for ion channels. • Developed MatLab code integrating data from Electron Microscopy and Residual Dipolar Coupling to generate Cyana restraints for pentameric structure calculations of the transmembrane domain of the glycine receptor. • Took on the task of utilizing Yen’s algorithm for K-shortest paths to determine the most efficient pathways for allosteric signaling • Implemented a Gaussian Mixture Model clustering algorithm in MatLab to determine drug-binding sites using NMR titration data and the protein structure. • Analyzed NMR titration data to identify likely drug interaction sites in ion channels. Show less



Leadscope, Inc.

• Software Development
• 1 - 100 Employee

• Intern

  • May 2007 - Jul 2007

  Columbus, Ohio Area I worked to create a method for error detection in high throughput screening data using cheminformatics



Eli Lilly and Company

• United States
• Pharmaceutical Manufacturing
• 700 & Above Employee

• Summer Replacement Student

  • May 2005 - Jul 2005

  Greenfield, IN Material Safety Data Sheet (MSDS) data entry and filing Performed literature searches for the toxicology department After hours, I shadowed a biochemist working on projects involving MALDI-TOF MS to learn about mass spectroscopy and research science in a pharmaceutical industry