Constance Le Gac
PhD student in Computational Systems Biology at ETH-Department of Biosystems Science and Engineering (D-BSSE)- Claim this Profile
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Bio
Credentials
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C2 Proficiency
Cambridge Assessment EnglishJan, 2014- Oct, 2024
Experience
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ETH-Department of Biosystems Science and Engineering (D-BSSE)
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Switzerland
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Higher Education
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1 - 100 Employee
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PhD student in Computational Systems Biology
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Oct 2022 - Present
During my PhD, I aim to design and use mathematical models for the study of the intestinal microbiome. During my PhD, I aim to design and use mathematical models for the study of the intestinal microbiome.
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Master Thesis in Computational Biology
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Mar 2022 - Sep 2022
During my master's thesis, I worked on developping a simulation framework to simulate the signalling network of CAR T cells. This led to the development of a fuzzy logic tool for the simulation of biological networks - see our paper "Fuzzy Logic for Biological Networks as ML Regression: Scaling to Single-Cell Datasets With Autograd" Le Gac, C., Driessen A., Deutschmann N. and Rodriguez Martinez M. in NeurIPS 2022 Workshop on Learning Meaningful Representations of Life. During my master's thesis, I worked on developping a simulation framework to simulate the signalling network of CAR T cells. This led to the development of a fuzzy logic tool for the simulation of biological networks - see our paper "Fuzzy Logic for Biological Networks as ML Regression: Scaling to Single-Cell Datasets With Autograd" Le Gac, C., Driessen A., Deutschmann N. and Rodriguez Martinez M. in NeurIPS 2022 Workshop on Learning Meaningful Representations of Life.
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ETH Zürich
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Switzerland
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Higher Education
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700 & Above Employee
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Research Internship in Computational Biology
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Jan 2022 - Feb 2022
Studied the Maximum Path Likelihood algorithm presented in Sohail et al. (2021) for fitness effects inference and its applicability to the simulated and experimental data. Studied the Maximum Path Likelihood algorithm presented in Sohail et al. (2021) for fitness effects inference and its applicability to the simulated and experimental data.
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ETH-Department of Biosystems Science and Engineering (D-BSSE)
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Switzerland
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Higher Education
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1 - 100 Employee
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Research internship in Computational Systems Biology
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Sep 2021 - Dec 2021
Worked on algorithms estimating population parameters from cell measurements snapshot data using Non-Linear Mixed Effects models. Worked on algorithms estimating population parameters from cell measurements snapshot data using Non-Linear Mixed Effects models.
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University of Bayreuth
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Germany
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Research Services
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700 & Above Employee
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Research Internship in Structural Bioinformatics
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Apr 2020 - Jul 2020
Study of TIM-barrel proteins and characterisation of a binding site present in many TIM-barrel protein families. Use of Pymol, Rosetta, Python. Study of TIM-barrel proteins and characterisation of a binding site present in many TIM-barrel protein families. Use of Pymol, Rosetta, Python.
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Inria
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France
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Research Services
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700 & Above Employee
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Research project in Computational Biology
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Sep 2019 - Mar 2020
Research project with INRIA's Lifeware team. Modelling of the respiratory function of red blood cells using the BIOCHAM environment. Dpcumentation and synthesis on red blood cells metabolism, use of linear temporal logic, model building and parameterization. Research project with INRIA's Lifeware team. Modelling of the respiratory function of red blood cells using the BIOCHAM environment. Dpcumentation and synthesis on red blood cells metabolism, use of linear temporal logic, model building and parameterization.
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Novadiscovery
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France
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Software Development
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1 - 100 Employee
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Biomodeller intern
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Jun 2019 - Aug 2019
Biomodeller intern at Novadiscovery. Realisation and synthesis of an extensive bibliography study on Physiologically-Based Pharmacokinetic Models, working in tandem with another intern. Implementation of one such model representing the whole body. Biomodeller intern at Novadiscovery. Realisation and synthesis of an extensive bibliography study on Physiologically-Based Pharmacokinetic Models, working in tandem with another intern. Implementation of one such model representing the whole body.
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École Polytechnique
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France
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Research Services
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700 & Above Employee
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Group research project on antibioresistance
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Sep 2018 - May 2019
Study of the apparition of antibiotic resistance in two strains of Corynebacterium Glutamicum: a wildtype strain and a cell deficient for DNA mismatch repair system. With one of my colleages, I was responsible for the informatics and modeling part of this project which aimed to emulate a Harvard Medical School experiment on the study of microbial evolution on antibiotic landscapes using a MEGA-plate (doi: 10.1126/science.aag0822). Two other colleagues focused on the experimental work. Study of the apparition of antibiotic resistance in two strains of Corynebacterium Glutamicum: a wildtype strain and a cell deficient for DNA mismatch repair system. With one of my colleages, I was responsible for the informatics and modeling part of this project which aimed to emulate a Harvard Medical School experiment on the study of microbial evolution on antibiotic landscapes using a MEGA-plate (doi: 10.1126/science.aag0822). Two other colleagues focused on the experimental work.
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Stagiaire Adjoint au Conseiller de Prévention
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Sep 2017 - Apr 2018
Rédaction du Document Unique de Prévention des Risques Professionnel pour la DDSP 80 Rédaction du Document Unique de Prévention des Risques Professionnel pour la DDSP 80
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Education
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2020 - 2022
ETH Zürich
Master's degree, Computational Biology and Bioinformatics -
2017 - 2021
École Polytechnique
Diplôme d'ingénieur, Biologie, Informatique, Mathématiques Appliquées -
2015 - 2017
Lycée aux Lazaristes, Lyon
MP Info, MP* -
2012 - 2015
Lycée Saint Vincent La Providence
Baccalauréat S SVT Option Internationale au Baccalauréat, Mention Très Bien
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