Clayton Rische
PhD Candidate at Northwestern University- Claim this Profile
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Bio
Experience
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Northwestern University
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United States
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Higher Education
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700 & Above Employee
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PhD Candidate
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2016 - Present
Bochner Lab - We are in the early stages of looking at the effects of receptor binding on the surface of mast cells. Our work encompasses a variety of approaches designed to identify novel ligands, evaluate ligand activity and affinity, and exploit mechanisms inherent to these receptors. We hope that our work will not only lead to new therapeutic approaches, but also elucidate on some of the biology of mast cells and related disease as well. Prior to working with Bruce Bochner, I was a… Show more Bochner Lab - We are in the early stages of looking at the effects of receptor binding on the surface of mast cells. Our work encompasses a variety of approaches designed to identify novel ligands, evaluate ligand activity and affinity, and exploit mechanisms inherent to these receptors. We hope that our work will not only lead to new therapeutic approaches, but also elucidate on some of the biology of mast cells and related disease as well. Prior to working with Bruce Bochner, I was a member of the TEAM Lab under Ramille Shah. In this work, I focused on looking at hepatocyte-specific regeneration in scaffolds fabricated with decellularized extracellular matrix derived from porcine liver. Show less Bochner Lab - We are in the early stages of looking at the effects of receptor binding on the surface of mast cells. Our work encompasses a variety of approaches designed to identify novel ligands, evaluate ligand activity and affinity, and exploit mechanisms inherent to these receptors. We hope that our work will not only lead to new therapeutic approaches, but also elucidate on some of the biology of mast cells and related disease as well. Prior to working with Bruce Bochner, I was a… Show more Bochner Lab - We are in the early stages of looking at the effects of receptor binding on the surface of mast cells. Our work encompasses a variety of approaches designed to identify novel ligands, evaluate ligand activity and affinity, and exploit mechanisms inherent to these receptors. We hope that our work will not only lead to new therapeutic approaches, but also elucidate on some of the biology of mast cells and related disease as well. Prior to working with Bruce Bochner, I was a member of the TEAM Lab under Ramille Shah. In this work, I focused on looking at hepatocyte-specific regeneration in scaffolds fabricated with decellularized extracellular matrix derived from porcine liver. Show less
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Exicure
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United States
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Biotechnology Research
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1 - 100 Employee
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Research Associate II
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Nov 2013 - Sep 2016
-Worked with senior scientists and technicians to create SNA constructs designed for therapeutic applications. -Collaborated with peers to develop experimental protocols and assays to investigate the therapeutic potential of various molecules. -Ran absorbance and luminescence assays to determine effects of SNAs on target cell cultures. -Synthesized and characterized nanoparticles and related constructs. -Worked with senior scientists and technicians to create SNA constructs designed for therapeutic applications. -Collaborated with peers to develop experimental protocols and assays to investigate the therapeutic potential of various molecules. -Ran absorbance and luminescence assays to determine effects of SNAs on target cell cultures. -Synthesized and characterized nanoparticles and related constructs.
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The Johns Hopkins University
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United States
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Higher Education
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700 & Above Employee
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Undergraduate Researcher
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Jan 2010 - Jul 2011
The Herrera-Alonso Laboratory My project studied the fabrication of nanoparticles from amphiphilic block copolymers. The process that was used to create these nanoparticles was flash nanoprecipitation (FNP). FNP allows for the fine tuning of particle size, as well as higher loading efficiency within each particle. The after synthesizing polycarprolactone, the polymer product was coupled with poly(N-isopropylacrylamide) (PNIPAAm) to produce temperature-sensitive amphiphilic block… Show more The Herrera-Alonso Laboratory My project studied the fabrication of nanoparticles from amphiphilic block copolymers. The process that was used to create these nanoparticles was flash nanoprecipitation (FNP). FNP allows for the fine tuning of particle size, as well as higher loading efficiency within each particle. The after synthesizing polycarprolactone, the polymer product was coupled with poly(N-isopropylacrylamide) (PNIPAAm) to produce temperature-sensitive amphiphilic block copolymers. Further experiments were required after all tests were completed, after data indicated a need for larger sample sizes and another sample set for comparison. Show less The Herrera-Alonso Laboratory My project studied the fabrication of nanoparticles from amphiphilic block copolymers. The process that was used to create these nanoparticles was flash nanoprecipitation (FNP). FNP allows for the fine tuning of particle size, as well as higher loading efficiency within each particle. The after synthesizing polycarprolactone, the polymer product was coupled with poly(N-isopropylacrylamide) (PNIPAAm) to produce temperature-sensitive amphiphilic block… Show more The Herrera-Alonso Laboratory My project studied the fabrication of nanoparticles from amphiphilic block copolymers. The process that was used to create these nanoparticles was flash nanoprecipitation (FNP). FNP allows for the fine tuning of particle size, as well as higher loading efficiency within each particle. The after synthesizing polycarprolactone, the polymer product was coupled with poly(N-isopropylacrylamide) (PNIPAAm) to produce temperature-sensitive amphiphilic block copolymers. Further experiments were required after all tests were completed, after data indicated a need for larger sample sizes and another sample set for comparison. Show less
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Education
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Northwestern University
Doctor of Philosophy - PhD -
Northwestern University
Master’s Degree -
The Johns Hopkins University
BS -
Barrington High School