Experience

Korro Bio, Inc.

• United States
• Biotechnology Research
• 1 - 100 Employee

• Principal Scientist

  • Mar 2022 - Present



Kaleido Biosciences

• United States
• Biotechnology Research
• 1 - 100 Employee

• Scientist II

  • Feb 2020 - Jan 2022

  Preclinical Pharmacology Working Group Lead - Designed experiments to address fundamental questions about Microbiome Metabolic Therapy (MMT) pharmacology to be conducted at CROs. - Collaborated with software team to take LIMS from proof of concept to companywide standard, for the purpose of registering, tracking, and collecting experimental details across all animal studies. This allowed us to centralize existing and new preclinical data as a resource for future study design. - Created… Show more Preclinical Pharmacology Working Group Lead - Designed experiments to address fundamental questions about Microbiome Metabolic Therapy (MMT) pharmacology to be conducted at CROs. - Collaborated with software team to take LIMS from proof of concept to companywide standard, for the purpose of registering, tracking, and collecting experimental details across all animal studies. This allowed us to centralize existing and new preclinical data as a resource for future study design. - Created a standardized mouse study framework to help streamline study design. - Collaborated with program teams to design preclinical studies that will answer program specific questions. Small Intestinal Microbiome Project Lead - Built platform to study the small intestinal microbiome by establishing a high-throughput (HT) 384-well format single strain assay to test our MMT library across multiple strains. Effort required close collaboration various departments, including software and automation groups for LIMS integration and liquid handling, respectively. - Trained junior scientists to be able to independently utilize this platform in support of collaborations (Johnson & Johnson). - Used platform to test and nominate compounds. Designed in vivo mouse models to evaluate their efficacy at CROs. - Clearly communicate rationale, hypothesis, results, recommendations, and drive discussions between Kaleido and collaborators. COPD Program Biology Lead. Responsible for providing preclinical strategy recommendations and coordinating study execution. Led the exploratory work to understand mechanism of action of MMTs tested in several Metabolic Health mouse models. The findings were summarized in a poster publication.

• Scientist

  • Mar 2017 - Feb 2020

  - Bile Acid Project Lead - Project lead for first assay scaled up using LIMs integration. - Researched potential biomarkers and designed experiments to evaluate their quantification in various sample types (bacterial supernatants, mouse and human fecal material). - Worked closely and cross functionally with clinical and translational scientists to evaluate the translatability of these biomarkers. Made recommendations for their inclusion in clinical trial design when appropriate. -… Show more - Bile Acid Project Lead - Project lead for first assay scaled up using LIMs integration. - Researched potential biomarkers and designed experiments to evaluate their quantification in various sample types (bacterial supernatants, mouse and human fecal material). - Worked closely and cross functionally with clinical and translational scientists to evaluate the translatability of these biomarkers. Made recommendations for their inclusion in clinical trial design when appropriate. - Designed preclinical mouse studies and coordinated with CROs to conduct work for several project teams. - Participated in interview and hiring process for scientific and clinical personnel. Interviewed, hired, and trained an RA and PhD level coop to support translational pharmacology work.



Yale University

• United States
• Higher Education
• 700 & Above Employee

• Postdoctoral Research Fellow

  • Oct 2013 - Feb 2017

  - Designed and performed experiments in gnotobiotic mice to determine the role of the gut microbiota in warfarin function and drug processing. - Received the NIH/NIGMS National Research Service Award (NRSA) Individual Postdoctoral Fellowship to support this work. - Wrote an IRB and received IRB approval for our clinical warfarin microbiome study and successfully recruited doctors from Yale New Haven Hospital’s Coumadin clinic to collaborate with us. - Developed cooperative arrangements… Show more - Designed and performed experiments in gnotobiotic mice to determine the role of the gut microbiota in warfarin function and drug processing. - Received the NIH/NIGMS National Research Service Award (NRSA) Individual Postdoctoral Fellowship to support this work. - Wrote an IRB and received IRB approval for our clinical warfarin microbiome study and successfully recruited doctors from Yale New Haven Hospital’s Coumadin clinic to collaborate with us. - Developed cooperative arrangements with other institutions (Tufts University) and Yale faculty that were critical to this work. - Trained graduate students and clinical GI fellow in laboratory techniques and in vivo dosing and handling techniques. Show less - Designed and performed experiments in gnotobiotic mice to determine the role of the gut microbiota in warfarin function and drug processing. - Received the NIH/NIGMS National Research Service Award (NRSA) Individual Postdoctoral Fellowship to support this work. - Wrote an IRB and received IRB approval for our clinical warfarin microbiome study and successfully recruited doctors from Yale New Haven Hospital’s Coumadin clinic to collaborate with us. - Developed cooperative arrangements… Show more - Designed and performed experiments in gnotobiotic mice to determine the role of the gut microbiota in warfarin function and drug processing. - Received the NIH/NIGMS National Research Service Award (NRSA) Individual Postdoctoral Fellowship to support this work. - Wrote an IRB and received IRB approval for our clinical warfarin microbiome study and successfully recruited doctors from Yale New Haven Hospital’s Coumadin clinic to collaborate with us. - Developed cooperative arrangements with other institutions (Tufts University) and Yale faculty that were critical to this work. - Trained graduate students and clinical GI fellow in laboratory techniques and in vivo dosing and handling techniques. Show less



UC San Diego

• United States
• Higher Education
• 700 & Above Employee

• Postdoctoral Scholar

  • Jan 2013 - Sep 2013

  - Used in vivo and in vitro approaches to further explore xenobiotic exposures and how they influence drug metabolism. - Presented on group’s current projects to incoming graduate students. Interviewed and evaluated students interested in becoming involved in group’s research. - Trained undergraduate and graduate students in laboratory techniques and provided scientific oversight in their studies.

• Pharmacology and Toxicology Teaching Assistant

  • Mar 2008 - Mar 2013

  Prepared discussion material, supervised teaching assistants, and graded as discussion section coordinator for Pharmacology and Toxicology.

• Graduate Student Researcher

  • Sep 2006 - Dec 2012

  - Planned and executed original dissertation research, focusing on the regulatory role of oral arsenic in humanized UGT1 mice. - Performed in vivo studies with humanized UGT1A1*28 mice. Demonstrated changes in serum unconjugated bilirubin can serve as a marker for environmental toxicant exposure. - Investigated CYP1A1 induction through aryl-hydrocarbon receptor activation by environmental toxicant ligands in a human CYP1A1-luciferase reporter gene cell line. - Studied in vitro… Show more - Planned and executed original dissertation research, focusing on the regulatory role of oral arsenic in humanized UGT1 mice. - Performed in vivo studies with humanized UGT1A1*28 mice. Demonstrated changes in serum unconjugated bilirubin can serve as a marker for environmental toxicant exposure. - Investigated CYP1A1 induction through aryl-hydrocarbon receptor activation by environmental toxicant ligands in a human CYP1A1-luciferase reporter gene cell line. - Studied in vitro dimerization between CYP3A4 and UGT1A1 by co-immunoprecipitation experiments. - Presented on group’s current projects to incoming graduate students. Interviewed and evaluated students interested in becoming involved in group’s research. - Trained undergraduate and graduate students in laboratory techniques and provided scientific oversight in their studies. - Awarded 2012 TA Excellence Award for teaching performance from Chemistry and Biochemistry department.



Amgen

• United States
• Biotechnology Research
• 700 & Above Employee

• Graduate Intern in PKDM

  • Jun 2011 - Sep 2011

  - Performed selective siRNA down regulation of UGT isoforms in human hepatocytes to evaluate the how UGT-UGT interactions influence enzyme activity. Monitored changes in metabolite formation due to disrupted protein interactions with HPLC-MS/MS. - This work resulted in a first author publication. - Performed selective siRNA down regulation of UGT isoforms in human hepatocytes to evaluate the how UGT-UGT interactions influence enzyme activity. Monitored changes in metabolite formation due to disrupted protein interactions with HPLC-MS/MS. - This work resulted in a first author publication.



Loyola Marymount University

• United States
• Higher Education
• 700 & Above Employee

• Organic Chemistry Teaching Assistant

  • Aug 2004 - Dec 2005



Loyola Marymount University

• United States
• Higher Education
• 700 & Above Employee

• Learning Resource Center Tutor

  • Aug 2002 - Jun 2004

  I tutored Chemistry and Math. I tutored Chemistry and Math.