Cintia Stival
Research Associate at Institute of Molecular and Cellular Biology of Rosario- Claim this Profile
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Español Native or bilingual proficiency
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Inglés Full professional proficiency
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Portugués Professional working proficiency
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Italiano Elementary proficiency
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Bio
Experience
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Institute of Molecular and Cell Biology of Rosario (IBR-CONICET-UNR)
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Argentina
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Research Services
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1 - 100 Employee
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Research Associate
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Apr 2019 - Present
Project: "Structural determinants of activity and non-canonical regulatory mechanisms of Protein Kinase A (PKA) in sperm physiology" Location: Cellular-Structural Biology Lab (coordinated by Andrés Binolfi, PhD) and Cell signal transduction networks (coordinated by Darío Krapf, PhD) Summary: PKA is a kinase enzyme that acts as a central coordinator of the sperm capacitation process. Previous work suggests that the regulation of this protein is complex and multifactorial, involving post translational modifications, such as acetylation, as well as active restriction of its subcellular localization. By using both in cellulo and in vitro studies with a recombinant version of PKA, we are investigating non-canonical regulation mechanisms for this enzyme. Show less
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Doctoral Fellow
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Apr 2014 - Apr 2019
Project: Differentiation between signaling pathways involved in hyperactivation and acrosome reaction during acquisition of fertilizing capacity in mammalsLocation: Cell Signal Transduction Networks Laboratory (coordinated by Darío Krapf, PhD)Summary: during my doctoral research, I characterized the signaling pathways that take place during the process of capacitation to allow mammalian sperm to fertilize an oocyte, using the murine and human experimental models. In particular, I studied the role of PKA and Src enzymes, and their association with different capacitation events. In a collaborative work, we developed a method to predict the outcome of Assisted Reproductive Techonologies (ART) by assessing sperm samples from male patients. Show less
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Lecturers Without Borders (LeWiBo)
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France
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Non-profit Organization Management
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1 - 100 Employee
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Education Consultant
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Mar 2021 - Present
Educational and scientific advisor with the main purpose of optimizing effective communication strategies related to STEM areas for different target audiences. Main tasks include: design and elaboration of infographics and written materials tailored for specific audiences, diagnosis and processing of surveys, data-based decision-making, strategic planning for assertive communication for young audiences, monitoring the effectiveness of the applied strategies and preparation of internal and external reports. Show less
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Universidad Nacional de Rosario
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Argentina
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Higher Education
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700 & Above Employee
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Laboratory Instructor, Biology Department
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2009 - Present
Prepare, manage and teach lab lessons and experimental practices in the undergrad courses "Biology" and "Animal and Plant Biology" at the School of Biochemistry and Pharmacy. Elaboration of didactic teaching material. Lesson planification and exams. Prepare, manage and teach lab lessons and experimental practices in the undergrad courses "Biology" and "Animal and Plant Biology" at the School of Biochemistry and Pharmacy. Elaboration of didactic teaching material. Lesson planification and exams.
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Universidad Nacional Autónoma de México
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Higher Education
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700 & Above Employee
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Estadía de investigación
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Jun 2017 - Sep 2017
Estadía de investigación para estudiar la señalización por calcio durante la capacitación espermática mediante microscopía en células vivas, en el laboratorio del Dr. Alberto Darszon en el Instituto de Biotecnología (Cuernavaca, México) de la UNAM. Estadía de investigación para estudiar la señalización por calcio durante la capacitación espermática mediante microscopía en células vivas, en el laboratorio del Dr. Alberto Darszon en el Instituto de Biotecnología (Cuernavaca, México) de la UNAM.
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Institute of Molecular and Cell Biology of Rosario (IBR-CONICET-UNR)
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Argentina
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Research Services
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1 - 100 Employee
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Undergraduate Research
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2011 - 2013
Project: “Design and characterization of a hybrid protein between matallo-β-lactamase of types B1 and B2” Location: Metalloproteins Lab Summary: metallo-β-lactamases are enzymes produced by different bacterial strains, that provide resistance to β-lactamic antibiotics (penicillins, cephalosporins, carbapenems). Such enzymes can be further sub-classified in three groups, each of them with different kinetic properties and substrate affinity. In order to identify structural elements that modulate substrate specificity, we designed, expressed, purified and characterized a chimeric enzyme that combines features of both metallo-β-lactamases B1 and metallo-β-lactamases B2. Show less
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Facultad de Ciencias Medicas, Universidad Nacional de Rosario
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Higher Education
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100 - 200 Employee
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Pasantía de investigación
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2009 - 2011
Proyecto: "Terapias emergentes en artritis reumatoidea" Lugar: Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes (coordinado por la Dra. Sara Feldman). Resumen: se desarrolló y caracterizó el modelo para investigación de artritis reumatoidea utilizando conejos New Zelland y se evaluó el efecto terapéutico del tratamiento con vitamina D. Proyecto: "Terapias emergentes en artritis reumatoidea" Lugar: Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes (coordinado por la Dra. Sara Feldman). Resumen: se desarrolló y caracterizó el modelo para investigación de artritis reumatoidea utilizando conejos New Zelland y se evaluó el efecto terapéutico del tratamiento con vitamina D.
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Education
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Universidad Nacional de Rosario - UNR
Doctora, Ciencias Biológicas -
University of Chicago Marine Biological Laboratory (MBL)
Intensive research and training program in reproductive science, Research techniques in Reproductive Science -
Universidad Nacional de Rosario
Licenciatura en Biotecnología