Experience

LifeArc

• United Kingdom
• Non-profit Organizations
• 200 - 300 Employee

• Principal Scientist

  • Aug 2022 - Present

• Project Lead Antibody Discovery

  • May 2019 - Present

  Senior scientist and project lead within LifeArc’s immuno-oncology alliance with CRUK-TDL and Ono Pharma for the discovery of antibodies against single- and multi-pass transmembrane targets.Oversight of project resource requirements, timelines, and budgeting; setting directions through scientific input, project planning and critical review of key data; engagement with internal stakeholders, alliance partners and CROs to reach project milestones.Reagent generation for immunisations; hit candidate screening; hit and lead candidate profiling.Line management responsibility



GSK

• United Kingdom
• Pharmaceutical Manufacturing
• 700 & Above Employee

• Molecular Biologist/Expression Scientist

  • Jul 2015 - Mar 2019

  Engineering, expression and biophysical characterisation of antibodies to deliver a novel bispecifics format; technology evaluation and development; due diligence; Fc engineering; training in project management; engagement with external stakeholders and collaborators to reach project milestones; working to tight project deadlines; training of staff and students. Engineering, expression and biophysical characterisation of antibodies to deliver a novel bispecifics format; technology evaluation and development; due diligence; Fc engineering; training in project management; engagement with external stakeholders and collaborators to reach project milestones; working to tight project deadlines; training of staff and students.



Syngenta

• Switzerland
• Farming
• 700 & Above Employee

• Scientific Researcher (maternity cover)

  • Sep 2014 - May 2015

  Fungicide resistance of plant pathogens poses a big problem in crop production. It is Syngenta's aim to find new and effective fungicides to overcome problems with resistances while ensuring that these products are safe for humans and nature. For this it is essential to know how exactly the individual fungicides work. Therefore, to find out more about the underlying modes of action of fungicides I am studying their effects in fungal model systems. Fungicide resistance of plant pathogens poses a big problem in crop production. It is Syngenta's aim to find new and effective fungicides to overcome problems with resistances while ensuring that these products are safe for humans and nature. For this it is essential to know how exactly the individual fungicides work. Therefore, to find out more about the underlying modes of action of fungicides I am studying their effects in fungal model systems.



NIMR

• Research Services
• 300 - 400 Employee

• Postdoctoral Researcher

  • Sep 2011 - Aug 2014

  Insufficient signalling via the cell-surface receptor CD95, a member of the TNF receptor family, is associated with increased autoimmunity and the development of cancer. The early steps of apoptotic CD95 signalling include the recruitment of the adaptor proteins Fas-associated death domain (FADD) and caspase-8 to the receptor to form large signalling platforms. My research at NIMR aims to improve our understanding of how the proteins interact in the CD95/FADD/caspase-8 complex. For this purpose, I am studying the protein interactions within the complex at the level of the cell and in vitro.



Newcastle University

• United Kingdom
• Higher Education
• 700 & Above Employee

• PhD

  • Jan 2008 - Jun 2011