Christian T. Denny
Postdoctoral Researcher at COLLAMEDIX INC.- Claim this Profile
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Bio
Experience
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COLLAMEDIX INC.
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United States
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Medical Equipment Manufacturing
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1 - 100 Employee
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Postdoctoral Researcher
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Jun 2022 - Present
Developing medical devices made from pure collagen biotextiles (CollaFabric) to improve patient recovery in the orthopaedic and female pelvic health space. Learning entrepreneurial skills critical for starting and running a medical device company. Investigating stem cell therapies that can improve ligament and tendon healing. - Developing a medical device from fabricated pure collagen thread that is industrially braided. - Project lead of a diverse team consisting of 8 members ranging from clinicians, professors, and students. - Operating a pre-clinical (in vivo) study to determine the safety and feasibility of our CollaFabric device. - Writing NIH, DOD, and nonprofit grants to raise money for current & future projects. - Analyzing histology to determine biocompatibility of implants in connective tissue using ISO 10993-1. - Immunohistochemistry staining of tendon-specific markers to determine tissue remodeling in the implant. - Developing a hydroxyapatite coating process to stimulate bone growth. - Running market research on biological devices in the orthopaedics industry. - Investigating stem cell therapies for improving implant integration for ligament and tendon healing. Show less
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The University of New Mexico School of Medicine
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Higher Education
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200 - 300 Employee
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Graduate Student Researcher
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Jan 2021 - May 2022
Investigated biodegradable polymers for making bioinks to 3D bioprint porous constructs for growing bone tissue. Researched a tissue engineered product to replace the bone-ligament interface in damaged ligaments of the hand and wrist. Participated in a regional NSF ICORP to do market research for a novel bioprinting system. - Synthesize fumarate-based polymers to make bioinks for 3D bioprinting. - Print bioinks to make 3D hard plastic constructs through photo crosslinking methods. - Grow primary osteoblasts on porous constructs to determine cell viability to the materials. - Organize and delegating assignments to a team of 5 students. - Write, edit, and publish scientific articles and grants. - Report project progress through reports and presentations. - Manage lab equipment usage, chemical and material stocks, and safety requirements. - Prepare purchase orders by verifying equipment specifications and obtaining quotes. - Develop projects to achieve overall lab goals. Show less
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The University of New Mexico
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United States
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Higher Education
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700 & Above Employee
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Graduate Research Assistant
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May 2018 - Dec 2020
Researched how material properties can direct aortic valve cells to represent aortic stenosis for a more relevant in vitro disease model. Tissue engineered a synthetic hydrogel platform to grow aortic heart valve cells in a 3D environment for modeling.- Synthesized poly(ethylene glycol) diacrylate and PEG-based polymers for culture model.- Created hydrogels through photo and thermal crosslinking methods.- Tested chemical (NMR, FTIR) and material (Sol-Swell, Compression Strength) of polymers and hydrogels to determine quality of the polymers and degree of hydrogel formation.- Extracted primary cells from pig aortic valve leaflets for cell stocks.- 3D cultured cells in a dynamic cell culturing system.- Used fluorescent microscopy to analyze cell viability within the hydrogels.- Helped write grant proposals to secure funding.- Wrote and published work in a scientific journal.- Built budgets for running projects. Show less
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Graduate Teaching Assistant
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Aug 2016 - Aug 2020
Taught courses in the biology and engineering department. Duties included building curriculum, developing online lectures, attending lab meetings, setting-up labs, performing dissections, running exams, holding office hours and grading.- Anatomy and Physiology I/II Labs (2 years)- Introduction to Statistics and Experimental Design (2 year)- Tissue Engineering (1 year)
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Assistant Laboratory Technician
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Aug 2016 - May 2017
Helped the lab technician in the organic chemistry teaching labs by preparing and maintaining experiments and lab equipment.- Restocked chemicals and prepared student manuals prior to the start of the semester.- Checked out and replaced equipment for students.- Presented safety training and maintained lab safety by checking for proper safety equipment and cleaning up any spills.- Ran UV-VIS, Gas Chromatography, and FT-IR analysis on students experiments.
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The University of New Mexico Health Sciences Center
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United States
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Hospitals and Health Care
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700 & Above Employee
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Graduate Research Assistant
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May 2017 - May 2018
Developed a hydrogel platform from decellularized human myocardium suffering from cardiomyopathy to grow cardiac progenitor cells for studying the pathological extracellular matrixes effects on cell differentiation. - Decellularization of heart muscle to obtain extracellular matrix. - Preparation of tissue for immunohistochemistry and tissue staining. - Histology of heart tissue for scar tissue. - Cell culture of cardiac progenitor cells. Developed a hydrogel platform from decellularized human myocardium suffering from cardiomyopathy to grow cardiac progenitor cells for studying the pathological extracellular matrixes effects on cell differentiation. - Decellularization of heart muscle to obtain extracellular matrix. - Preparation of tissue for immunohistochemistry and tissue staining. - Histology of heart tissue for scar tissue. - Cell culture of cardiac progenitor cells.
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Huntington Learning Center
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United States
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Education Administration Programs
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1 - 100 Employee
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Subject Tutor
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Jan 2016 - Jul 2016
Tutored all subjects for children ranging from kindergarten to high school, and prepared high school students for college entrance exam preparation. - Aided students with their homework and test preparation by reviewing class content, questions, and papers. - Taught children (5-12 years old) with the Huntington’s tutoring curriculum. - Trained students for the ACT, SAT, and ASVAB through structured curriculum. - Reported student progress to managers and parents through in-person meetings and written reports. Show less
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Boise State University
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United States
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Higher Education
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700 & Above Employee
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Research Assistant (Post-Bachelor)
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Feb 2016 - Jun 2016
Assisted in starting a project that investigated the cytotoxicity of electronic cigarette (e-cigs) liquid, with nicotine and without nicotine, on mouse lung epithelial cells - Mammalian cell culture to grow the lung cells for testing - Fluorescent metabolic cell assay to quantify cell viability when exposed to e-cig liquids - Statistical analysis and graph design using Prism - GraphPad Ran genotyping to help with a mouse breeding project to up-regulate the aryl hydrocarbon receptor in mouse liver cells for testing the effects of TCDD toxin. - DNA extractions from mouse biopsies - Gel-electrophoresis and imaging to identify specific marker genes - Catalog mouse pedigree Show less
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Idaho State University
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Higher Education
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700 & Above Employee
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Undergraduate Research Assistant
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May 2014 - Jan 2015
Aided in a project that was characterizing the gnome of a bacteriophage (phage) that is pathogenic to the bacteria Bacillus anthracis (Anthrax). - NIH Basic Local Alignment Sequence Searches (BLAST) to compare phage’s genetic identity to other known viruses. - Microbiological cell culture of phages in bacteria to maintain stocks of phage for genetic sequencing Aided in a project that was characterizing the gnome of a bacteriophage (phage) that is pathogenic to the bacteria Bacillus anthracis (Anthrax). - NIH Basic Local Alignment Sequence Searches (BLAST) to compare phage’s genetic identity to other known viruses. - Microbiological cell culture of phages in bacteria to maintain stocks of phage for genetic sequencing
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Education
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University of New Mexico School of Engineering
Doctor of Philosophy (Ph.D.), Biomedical Engineering -
University of New Mexico School of Engineering
Master's in Biomedical Engineering, Biomaterial, Biomechanics & Tissue Engineering -
Idaho State University
Biology, Biomedical Sciences