Experience

Connecticut Convergence Institute

• United States
• Hospitals and Health Care
• 1 - 100 Employee

• Research Fellow

  • Feb 2020 - Present

  • Develop a procedure to investigate a novel biomimetic scaffold that support complex ligament regeneration (Synthetic anterior cruciate ligament). • Designed and carried out an investigation on a novel chelation therapy involving dimercaprol agent for the treatment of arthroplasty related metallosis (arthroplasty wear and corrosion complication). • Designed a chronic rat model for the evaluation of arthroplasty related metallosis using cobalt ions and particles encapsulated in PLGA microsphere • Designed a slow release/long lasting treatment for arthroplasty related metallosis using BAL-HA encapsulated in PLGA microsphere Show less



Radiology Department, Washington University in St Louis School of Medicine

• St Louis, Missouri, United States

• Research And Development Scientist

  • Dec 2019 - Feb 2020

  • Identified the resident skeletal/progenitor cells within the bone microenvironment, which are retained post-Cerenkov Radiation-Induced Therapy (CRIT), as tissue engineering/regenerative medicine targets to improve cancer remission. • Identified the resident skeletal/progenitor cells within the bone microenvironment, which are retained post-Cerenkov Radiation-Induced Therapy (CRIT), as tissue engineering/regenerative medicine targets to improve cancer remission.



Orthopedic Dept, Washington University School of Medicine in St. Louis

• St Louis, Missouri, United States

• Research Fellow

  • Jul 2018 - Nov 2019

  • Optimized and carried out investigation on methods of periosteum derived progenitor cells (PDPC)’ harvest, and culture for maximum cell yield for utilization in the treatment of non-union bone fracture, and traumas. • Designed the experiments and evaluated the energy level (oxidative respiration/glycolysis), and the differentiation related inflammation/ autophagy occurring in PDPCs during osteogenesis to further the understanding of their contribution in bone healing/regeneration. • Designed the experiments and evaluated the possibility of EP1 antagonist to rescue the degradation effect of IL-1b in osteoarthritis using the osteoblast lineage induction. Show less



National Defence University of Malaysia

• Kuala Lumpur, Malaysia

• Laboratory Operations Manager

  • Oct 2016 - Jun 2018

  • Established a Tissue Engineering laboratory with a standard quality management system. • Developed SOPs for various cell culture methods/ molecular evaluation techniques / fundamental tissue engineering experimental methods. • Trained postgraduates, new science and research officers on laboratory procedures and cell culture works. • Build and lead an effective research team comprising of postgraduates and staff scientists that resulted in 4 high impact publications and scientific presentations. • Actively participated in management review meetings, and kept an up-to-date inventory of materials related to research activities. • Wrote proposals to obtain research funding/ grants. Show less



Tissue Engineering Center, PPUKM

• Federal Territory of Kuala Lumpur, Malaysia

• Deputy Production Manager

  • Apr 2015 - Sep 2016

  • Established and implemented production processes in a standard quality management system that increased outputs in 2 cell therapy products. • Build and led an effective and cohesive production team that pursued 4 R&D product developments and GMP standard, ready for clinical applications. • Trained graduate students and staff scientists on tissue engineering protocols, cell therapy, research design, and proposal development. • Teach introductory courses on cell biology, tissue engineering, and cell culture techniques to undergraduate students on 6 months attachment • Actively participated in the Management Review Committee that produced effective working standards for the Center • Negotiated product prices with clients, regulatory authorities, and vendors, while ensuring continued enhancement of services Show less



UKM

• Higher Education
• 700 & Above Employee

• Production Supervisor

  • Jun 2014 - Apr 2015

  • Carried out a dry-run for a novel chondrogenic induced cell therapy that led to the pursuit of a multi-centric , phase I/IIA, clinical trial of the chondrogenically induced BMSCs, for the treatment of osteoarthritis and focal cartilage defects.• Developed technical credibility with patients, clinicians, external institutions, and vendors to provide a consultative relationship and advance the technical dialog to achieve the common end goals.• Identified cell culture problems, proffer solutions and potential media development projects with commercial potential.• Directed the activities of chondrocyte production team and technical consultation for change control plans. Show less

• Product Specialist

  • Dec 2013 - Jun 2014

  Designed and developed 2 clinically applicable induction media for chondrogenically induced adipose stem cells, and bone marrow stem cells for utilization in cell therapy for osteoarthritis.Supervised and led chondrocyte production from R&D stage to the cGMP standard.



Tissue Engineering Center HUKM

• National University of Malaysia

• Doctoral Student

  • Mar 2011 - Jun 2014

  • Evaluated the surgical induction of osteoarthritis, similar to traumatic sports injuries that cause secondary osteoarthritis, in big animal models. • Induced bone marrow stem cells and adipose derived stem cells to chondrogenic lineage, using a special cocktail and evaluated the effectiveness of these products as chondrocyte substitutes. • Carried out osteoarthritic cartilage regeneration in big animal model via injectable chondrogenic cells, using specially designed cocktails • Tracked and monitored the participation of these injected chondrogenic cells in cartilage regeneration with fluorescent dye, and evaluated the biomechanical, and functional outcome of the regenerated cartilages. These studies yielded 6 high impact first authored papers, and 10 scientific presentations in conferences Show less