Chidambaram Ramanathan
Scientist at CirQuest Labs- Claim this Profile
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Bio
Viswanathan (Vish) Muthusamy
I worked with Dr. Chidambaram as a graduate student. He is one of the most hard-working and meticulous researcher I have encountered in all my career. I admire his tenacity in going after and completing projects against mounting logistical and financial constraints. He is an expert in the field of molecular genetics in relation to circadian biology. I remember that he during the course of his PhD, he developed a novel molecular association studies for analysis of complex behavioral phenotypes. He went on further and worked independently to establish various methodologies in the field of behavioral genetics and has pioneered several studies which have resulted in high impact publications. He has considerable technical experience in all aspects of the modern biology laboratory including cell culture, molecular biology and biochemistry. Dr. Chidambaram never disappoints in timely completion of any task accorded to him and would be a valuable asset to any research institution. I highly recommend him for research positions in his field of interest without any reservations.
Sanjoy Khan
I worked directly with Chidambaram from 2010-2012 at the University of Memphis during my PhD. He was my senior lab mate and helped me learn many aspects of circadian clock function. During my time at the University of Memphis, he developed novel metabolically relevant circadian clock reporter lines which are being now used as excellent models to study the role of circadian clocks in metabolism. Rarely, I have met someone like Chida in my 12 years of research life, who can match his intellect and motivation. He has the ability to design and execute any science project intelligently on his own. He was the go to man for any technically challenging technique or experiment in our group. Chida successfully developed high-throughput genetic and chemical screens for identification circadian clock modifiers. He is a quick adopter of new exciting technologies, for example he quickly adopted CRISPR/Cas9 genome editing technique to generate knockout cell lines to identify novel circadian clock modifiers. He always comes with new ideas and he is enthusiastic and ambitious. He is capable of inspiring and motivating his peers who work with him to learn more about science and new methods. The science I learned along with him is still playing a role in shaping my career. He is very serious about his work and knows how to make it interesting to others. He is intelligent, as much as he is involved in his subject. A good friend and colleague to move with and definitely he will leave a long lasting impression on anyone. I recommend him very highly.
Viswanathan (Vish) Muthusamy
I worked with Dr. Chidambaram as a graduate student. He is one of the most hard-working and meticulous researcher I have encountered in all my career. I admire his tenacity in going after and completing projects against mounting logistical and financial constraints. He is an expert in the field of molecular genetics in relation to circadian biology. I remember that he during the course of his PhD, he developed a novel molecular association studies for analysis of complex behavioral phenotypes. He went on further and worked independently to establish various methodologies in the field of behavioral genetics and has pioneered several studies which have resulted in high impact publications. He has considerable technical experience in all aspects of the modern biology laboratory including cell culture, molecular biology and biochemistry. Dr. Chidambaram never disappoints in timely completion of any task accorded to him and would be a valuable asset to any research institution. I highly recommend him for research positions in his field of interest without any reservations.
Sanjoy Khan
I worked directly with Chidambaram from 2010-2012 at the University of Memphis during my PhD. He was my senior lab mate and helped me learn many aspects of circadian clock function. During my time at the University of Memphis, he developed novel metabolically relevant circadian clock reporter lines which are being now used as excellent models to study the role of circadian clocks in metabolism. Rarely, I have met someone like Chida in my 12 years of research life, who can match his intellect and motivation. He has the ability to design and execute any science project intelligently on his own. He was the go to man for any technically challenging technique or experiment in our group. Chida successfully developed high-throughput genetic and chemical screens for identification circadian clock modifiers. He is a quick adopter of new exciting technologies, for example he quickly adopted CRISPR/Cas9 genome editing technique to generate knockout cell lines to identify novel circadian clock modifiers. He always comes with new ideas and he is enthusiastic and ambitious. He is capable of inspiring and motivating his peers who work with him to learn more about science and new methods. The science I learned along with him is still playing a role in shaping my career. He is very serious about his work and knows how to make it interesting to others. He is intelligent, as much as he is involved in his subject. A good friend and colleague to move with and definitely he will leave a long lasting impression on anyone. I recommend him very highly.
Viswanathan (Vish) Muthusamy
I worked with Dr. Chidambaram as a graduate student. He is one of the most hard-working and meticulous researcher I have encountered in all my career. I admire his tenacity in going after and completing projects against mounting logistical and financial constraints. He is an expert in the field of molecular genetics in relation to circadian biology. I remember that he during the course of his PhD, he developed a novel molecular association studies for analysis of complex behavioral phenotypes. He went on further and worked independently to establish various methodologies in the field of behavioral genetics and has pioneered several studies which have resulted in high impact publications. He has considerable technical experience in all aspects of the modern biology laboratory including cell culture, molecular biology and biochemistry. Dr. Chidambaram never disappoints in timely completion of any task accorded to him and would be a valuable asset to any research institution. I highly recommend him for research positions in his field of interest without any reservations.
Sanjoy Khan
I worked directly with Chidambaram from 2010-2012 at the University of Memphis during my PhD. He was my senior lab mate and helped me learn many aspects of circadian clock function. During my time at the University of Memphis, he developed novel metabolically relevant circadian clock reporter lines which are being now used as excellent models to study the role of circadian clocks in metabolism. Rarely, I have met someone like Chida in my 12 years of research life, who can match his intellect and motivation. He has the ability to design and execute any science project intelligently on his own. He was the go to man for any technically challenging technique or experiment in our group. Chida successfully developed high-throughput genetic and chemical screens for identification circadian clock modifiers. He is a quick adopter of new exciting technologies, for example he quickly adopted CRISPR/Cas9 genome editing technique to generate knockout cell lines to identify novel circadian clock modifiers. He always comes with new ideas and he is enthusiastic and ambitious. He is capable of inspiring and motivating his peers who work with him to learn more about science and new methods. The science I learned along with him is still playing a role in shaping my career. He is very serious about his work and knows how to make it interesting to others. He is intelligent, as much as he is involved in his subject. A good friend and colleague to move with and definitely he will leave a long lasting impression on anyone. I recommend him very highly.
Viswanathan (Vish) Muthusamy
I worked with Dr. Chidambaram as a graduate student. He is one of the most hard-working and meticulous researcher I have encountered in all my career. I admire his tenacity in going after and completing projects against mounting logistical and financial constraints. He is an expert in the field of molecular genetics in relation to circadian biology. I remember that he during the course of his PhD, he developed a novel molecular association studies for analysis of complex behavioral phenotypes. He went on further and worked independently to establish various methodologies in the field of behavioral genetics and has pioneered several studies which have resulted in high impact publications. He has considerable technical experience in all aspects of the modern biology laboratory including cell culture, molecular biology and biochemistry. Dr. Chidambaram never disappoints in timely completion of any task accorded to him and would be a valuable asset to any research institution. I highly recommend him for research positions in his field of interest without any reservations.
Sanjoy Khan
I worked directly with Chidambaram from 2010-2012 at the University of Memphis during my PhD. He was my senior lab mate and helped me learn many aspects of circadian clock function. During my time at the University of Memphis, he developed novel metabolically relevant circadian clock reporter lines which are being now used as excellent models to study the role of circadian clocks in metabolism. Rarely, I have met someone like Chida in my 12 years of research life, who can match his intellect and motivation. He has the ability to design and execute any science project intelligently on his own. He was the go to man for any technically challenging technique or experiment in our group. Chida successfully developed high-throughput genetic and chemical screens for identification circadian clock modifiers. He is a quick adopter of new exciting technologies, for example he quickly adopted CRISPR/Cas9 genome editing technique to generate knockout cell lines to identify novel circadian clock modifiers. He always comes with new ideas and he is enthusiastic and ambitious. He is capable of inspiring and motivating his peers who work with him to learn more about science and new methods. The science I learned along with him is still playing a role in shaping my career. He is very serious about his work and knows how to make it interesting to others. He is intelligent, as much as he is involved in his subject. A good friend and colleague to move with and definitely he will leave a long lasting impression on anyone. I recommend him very highly.
Experience
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CirQuest Labs
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United States
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Research Services
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1 - 100 Employee
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Scientist
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Oct 2017 - Present
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The University of Memphis
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United States
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Higher Education
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700 & Above Employee
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Research Assistant Professor
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Jun 2010 - Sep 2017
Established and executed high-throughput genetic and chemical screens for identification circadian clock modifiers (PLoS Genetics, 2014). Established metabolically relevant cell-autonomous clock reporter cell lines to screen additional circadian clock genes (JoVE, 2012). Identified and characterized “Chrono” as a one of the circadian clock gene (PLoS Biology, 2014) Implemented the shRNA screening for clock modifiers using the circadian clock reporter cell lines and… Show more Established and executed high-throughput genetic and chemical screens for identification circadian clock modifiers (PLoS Genetics, 2014). Established metabolically relevant cell-autonomous clock reporter cell lines to screen additional circadian clock genes (JoVE, 2012). Identified and characterized “Chrono” as a one of the circadian clock gene (PLoS Biology, 2014) Implemented the shRNA screening for clock modifiers using the circadian clock reporter cell lines and identified 34 clock modifiers. It resulted in collaborative studies and high impact follow up publications. Biochemical and molecular characterized 34 clock modifiers in circadian physiology (Nature Structural Molecular Biology, 2015). Identified 12 chemical targets of clock modifiers using LOPAC chemical library screening. It resulted in collaborative studies and high impact follow up publications. Successfully knockout (KO) a list of selected clock modifiers using CRISPR/Cas9 technology in MMH-D3 circadian reporter cell line to study clock functions. It resulted in collaborative studies and high impact follow up publications. Constructed and cloned many AAV and lentiviral FLAG tagged protein coding genes. Overexpressed recombinant proteins and characterized clock phenotypes and downstream signaling effects in mammalian cell lines. The reagent has been used by my lab members and our collaborators. Drafted protocols for the generation of luciferase reporter cell lines, and high-throughput formats to screen for clock modifiers. Our lab members and collaborators has been using the protocol for their research. Managed a team of 10 research associates and their research efforts. Achievements: Published four research articles; patent application submission; my data contributed to the award of over $5 million in a NIH grant. Show less Established and executed high-throughput genetic and chemical screens for identification circadian clock modifiers (PLoS Genetics, 2014). Established metabolically relevant cell-autonomous clock reporter cell lines to screen additional circadian clock genes (JoVE, 2012). Identified and characterized “Chrono” as a one of the circadian clock gene (PLoS Biology, 2014) Implemented the shRNA screening for clock modifiers using the circadian clock reporter cell lines and… Show more Established and executed high-throughput genetic and chemical screens for identification circadian clock modifiers (PLoS Genetics, 2014). Established metabolically relevant cell-autonomous clock reporter cell lines to screen additional circadian clock genes (JoVE, 2012). Identified and characterized “Chrono” as a one of the circadian clock gene (PLoS Biology, 2014) Implemented the shRNA screening for clock modifiers using the circadian clock reporter cell lines and identified 34 clock modifiers. It resulted in collaborative studies and high impact follow up publications. Biochemical and molecular characterized 34 clock modifiers in circadian physiology (Nature Structural Molecular Biology, 2015). Identified 12 chemical targets of clock modifiers using LOPAC chemical library screening. It resulted in collaborative studies and high impact follow up publications. Successfully knockout (KO) a list of selected clock modifiers using CRISPR/Cas9 technology in MMH-D3 circadian reporter cell line to study clock functions. It resulted in collaborative studies and high impact follow up publications. Constructed and cloned many AAV and lentiviral FLAG tagged protein coding genes. Overexpressed recombinant proteins and characterized clock phenotypes and downstream signaling effects in mammalian cell lines. The reagent has been used by my lab members and our collaborators. Drafted protocols for the generation of luciferase reporter cell lines, and high-throughput formats to screen for clock modifiers. Our lab members and collaborators has been using the protocol for their research. Managed a team of 10 research associates and their research efforts. Achievements: Published four research articles; patent application submission; my data contributed to the award of over $5 million in a NIH grant. Show less
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Michigan State University
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United States
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Higher Education
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700 & Above Employee
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Research Associate
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Sep 2003 - May 2010
Identified similar input components of circadian system between diurnal Nile grass rat and nocturnal rodents. It resulted two main publications (Neuroscience, 2009; Brain Behav. Evol., 2010) Identified similar clock protein expression profiles between diurnal Nile grass rat and nocturnal rodents in central circadian pacemaker of the SCN. It resulted two publications (Brain Research 2006; Neuroscience, 2010) Discovered differences of clock protein expression profiles in extra-SCN… Show more Identified similar input components of circadian system between diurnal Nile grass rat and nocturnal rodents. It resulted two main publications (Neuroscience, 2009; Brain Behav. Evol., 2010) Identified similar clock protein expression profiles between diurnal Nile grass rat and nocturnal rodents in central circadian pacemaker of the SCN. It resulted two publications (Brain Research 2006; Neuroscience, 2010) Discovered differences of clock protein expression profiles in extra-SCN oscillators of brain between diurnal and nocturnal mammals. It resulted three publications (Neuroscience Letters, 2008; 2010; Neuroscience, 2010). Studied shift work problems. Discovered desynchronized clock affect temporal organization of many important brain functions, which leads to the multiple pathologies associated with human shift work.(Neuroscience, 2010). Conducted research on neurodegenerative diseases such as Glaucoma. Characterized the role of BDNF in glaucomatous disease using cat model system. it resulted one publication (Invest Ophthalmol Vis Sci. 2009) Trained and supervised six undergraduate students and three technicians on their research efforts. Achievements: Written and published 13 research articles. Techniques used: Small rodent handling and survival surgery (e.g., cannulation, gonadectomy, and optic nerve crush); tract tracing method: neuronal anterograde and retrograde (e.g., BDA and choleratoxin); perfusion of lab rats and grass rats and collections of brain and peripheral tissues to measure clock gene/protein expression; Immunohistology (e.g., single, double, triple labeling) and microscopy (e.g., light and fluorescent imaging); In-situ hybridization in fresh and frozen brain tissue; neuroanatomy; monitoring of gross locomotor activity and body temperature of small rodents via emitters; developed glaucoma model in cats; perfusion of cat and collection of brain and eye tissues to study the functions of the visual cortex and the ganglian cell physiology Show less Identified similar input components of circadian system between diurnal Nile grass rat and nocturnal rodents. It resulted two main publications (Neuroscience, 2009; Brain Behav. Evol., 2010) Identified similar clock protein expression profiles between diurnal Nile grass rat and nocturnal rodents in central circadian pacemaker of the SCN. It resulted two publications (Brain Research 2006; Neuroscience, 2010) Discovered differences of clock protein expression profiles in extra-SCN… Show more Identified similar input components of circadian system between diurnal Nile grass rat and nocturnal rodents. It resulted two main publications (Neuroscience, 2009; Brain Behav. Evol., 2010) Identified similar clock protein expression profiles between diurnal Nile grass rat and nocturnal rodents in central circadian pacemaker of the SCN. It resulted two publications (Brain Research 2006; Neuroscience, 2010) Discovered differences of clock protein expression profiles in extra-SCN oscillators of brain between diurnal and nocturnal mammals. It resulted three publications (Neuroscience Letters, 2008; 2010; Neuroscience, 2010). Studied shift work problems. Discovered desynchronized clock affect temporal organization of many important brain functions, which leads to the multiple pathologies associated with human shift work.(Neuroscience, 2010). Conducted research on neurodegenerative diseases such as Glaucoma. Characterized the role of BDNF in glaucomatous disease using cat model system. it resulted one publication (Invest Ophthalmol Vis Sci. 2009) Trained and supervised six undergraduate students and three technicians on their research efforts. Achievements: Written and published 13 research articles. Techniques used: Small rodent handling and survival surgery (e.g., cannulation, gonadectomy, and optic nerve crush); tract tracing method: neuronal anterograde and retrograde (e.g., BDA and choleratoxin); perfusion of lab rats and grass rats and collections of brain and peripheral tissues to measure clock gene/protein expression; Immunohistology (e.g., single, double, triple labeling) and microscopy (e.g., light and fluorescent imaging); In-situ hybridization in fresh and frozen brain tissue; neuroanatomy; monitoring of gross locomotor activity and body temperature of small rodents via emitters; developed glaucoma model in cats; perfusion of cat and collection of brain and eye tissues to study the functions of the visual cortex and the ganglian cell physiology Show less
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Education
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1997 - 2003
Madurai Kamaraj University
Doctor of Philosophy (PhD), Neurobiology and Behavior
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