Chaitali Saqcena
Research Scientist at Cellecta, Inc.- Claim this Profile
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Bio
Experience
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Cellecta, Inc.
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United States
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Biotechnology Research
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1 - 100 Employee
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Research Scientist
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Feb 2023 - Present
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Albert Einstein College of Medicine
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United States
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Higher Education
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700 & Above Employee
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Visiting Research Scientist
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Aug 2021 - Feb 2022
Finish up my project work 'Autophagy Modulation in NPC1 mice using small molecule drugs Data generation, analysis, and writing manuscript on the same
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Postdoctoral Research Fellow
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May 2018 - Jul 2021
Lab of Dr. Steven U. Walkley and Dr. Kostainin Dobrenis Investigated the effect of small molecule autophagy modulators as a potential therapeutic agent in Niemann’s Pick C1 (NPC1) mouse model. Identified the role of AKT/mTOR signaling pathway in a feline model of Sandhoff’s disease. Collaborated with clinician scientist and pathologists to investigate ectopic dendrite formation in feline and mouse models. Mentored an undergraduate student, as well as a master’s thesis research… Show more Lab of Dr. Steven U. Walkley and Dr. Kostainin Dobrenis Investigated the effect of small molecule autophagy modulators as a potential therapeutic agent in Niemann’s Pick C1 (NPC1) mouse model. Identified the role of AKT/mTOR signaling pathway in a feline model of Sandhoff’s disease. Collaborated with clinician scientist and pathologists to investigate ectopic dendrite formation in feline and mouse models. Mentored an undergraduate student, as well as a master’s thesis research project. Communicated discoveries at internal and external research symposiums. Coordinated complex project plans and adhered to tight grant deadlines. Mentored undergraduate thesis project, Albert Einstein College of Medicine, NY 2018 – 2020 Pathophysiological study of NPC1 disease in the zebrafish model. Investigated the role of cholesterol metabolizing enzyme CYP46A1 in Niemann-Pick type C disease.
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Rutgers University - Newark
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United States
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Higher Education
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700 & Above Employee
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Ph.D.
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Jan 2011 - May 2018
Under the guidance of Dr. Radek Dobrowolski and Dr. Edward Bonder. We published four coauthor papers with colleagues and collaborators, the first author paper in the process. Examined impaired autophagy and integrated stress response in rat cortex after Traumatic Brain Injury (TBI). We identified that TAT-Beclin1 peptide attenuates neuronal cell death in vivo by increasing functional autophagy and decreasing integrated stress response after TBI (Manuscript in revision… Show more Under the guidance of Dr. Radek Dobrowolski and Dr. Edward Bonder. We published four coauthor papers with colleagues and collaborators, the first author paper in the process. Examined impaired autophagy and integrated stress response in rat cortex after Traumatic Brain Injury (TBI). We identified that TAT-Beclin1 peptide attenuates neuronal cell death in vivo by increasing functional autophagy and decreasing integrated stress response after TBI (Manuscript in revision, Autophagy). We identified sequestration of Dishevelled-1, a mediator of Wnt signaling, in autophagosomes in the rat cortex after TBI and in vitro models. We also engineered mouse radial glial cells, RG 3.6, for conditional expression of exogenous growth factor IGF-1 and transcription factor TFEB.
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Teaching Assistant
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Jan 2011 - Jul 2014
Under Dr. Miguel Cervantes-Cervantes Laboratory course in general Biology. Laboratory course in General Microbiology.
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Royal College of Arts, Commerce and Science
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Thane, Maharashtra, India
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College Lecturer
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Jul 2007 - Dec 2007
Taught undergraduate courses having both laboratory and theory component • Molecular Biology. • Animal Biotechnology. Taught undergraduate courses having both laboratory and theory component • Molecular Biology. • Animal Biotechnology.
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ICMR - National Institute for Research in Reproductive and Child Health (NIRRCH)
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India
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Research Services
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100 - 200 Employee
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Senior Research Fellow
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Feb 2005 - Feb 2006
Under the guidance of Dr. Kudumula V. R. Reddy, We Isolated antimicrobial peptides from the hemolymph of the Indian mud crab Scylla serrata. The peptide was isolated using Size exclusion chromatography and High-performance liquid chromatography. We tested the isolated, pure peptide for its antimicrobial activity against Gram-positive and Gram-negative bacteria. Under the guidance of Dr. Kudumula V. R. Reddy, We Isolated antimicrobial peptides from the hemolymph of the Indian mud crab Scylla serrata. The peptide was isolated using Size exclusion chromatography and High-performance liquid chromatography. We tested the isolated, pure peptide for its antimicrobial activity against Gram-positive and Gram-negative bacteria.
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Education
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Rutgers University - Newark
Doctorate, Biological Sciences -
St. Xavier's College
Master's degree, Life Sciences -
Royal College of Arts, Commerce and Science
Bachelor's degree, Microbiology