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Chad Pope, PhD

Scientist - Analytical Sciences & Technology at Emergent BioSolutions

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Contact Information

us****@****om

(386) 825-5501

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Location

Lawrence, Kansas, United States, US

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Credentials

Animal Handling

University of Kansas Medical Center
Good Laboratory Practices

Sekisui XenoTech, LLC

Experience

Emergent BioSolutions

United States
Biotechnology Research
700 & Above Employee

Scientist - Analytical Sciences & Technology
- Apr 2023 - Present
Analytical method transfer and validation of scientific methods in support of pharmaceutical manufacturing. Develop methods (HPLC, molecular biology, and raw material resin performance qualification) via optimization, troubleshooting, and investigations. Act as a Subject Matter Expert. Author Test Method Documents, Validation Protocols, Validation Reports, and Forms for execution. Train QC analysts to execute methods and review documentation and data. Perform Quality actions including Risk Assessments, Change Controls, Deviations, CAPAs, and Root Cause Analysis ensuring compliance with current FDA and other regulatory requirements. Maintain analytical methods and instruments in a cGMP compliant state. Perform statistical analysis of technology transfer and assay performance data. Review protocols and reports from contract laboratories for compendial methods to qualify raw materials. Show less

Thermo Fisher Scientific

United States
Biotechnology Research
700 & Above Employee

Quality Specialist II
- Jan 2023 - Apr 2023
Perform Post Market Surveillance on products for HLA typing and matching between organ transplant donors and recipients utilizing NGS, Single-stranded oligonucleotide typing bead-based multiplexing assays and Flow Cytometry to assess stability of reagents and new products for market. Analyze data and author stability assessment reports. Perform Post Market Surveillance on products for HLA typing and matching between organ transplant donors and recipients utilizing NGS, Single-stranded oligonucleotide typing bead-based multiplexing assays and Flow Cytometry to assess stability of reagents and new products for market. Analyze data and author stability assessment reports.

The Niva Labs

Los Angeles, California, United States

Research Scientist - Analytical Chemist
- Jun 2021 - Jan 2023
Research Scientist and Analytical Chemist for a California state regulated cannabis laboratory. Account manager for cannabis beverage companies interfacing with clients. Analytical chemist with experience in LC-MS/MS, GC-MS/MS, and HPLC responsible for measuring cannabinoid concentrations and pesticide detection. Lead scientist for research including PK analysis for the disposition of novel CBD formulations in rats, skin absorption studies assessing permeability of cannabinoids in topicals and wound healing capabilities, stability studies examining chemical stability assessing degradation and chemical conversion in different product formulations (gummies, beverages, topicals, etc.), and formulation compatibility studies ensuring solubility of emulsions. Developed assays for preservative resistant yeast detection and plant nuclear DNA isolation. Assisted with analytical method development (LC-MS/MS and HPLC) for organic acids, withanolides, and curcuminoids. Performed microbiology DNA qPCR analysis and plating assays testing for bacterial and fungal pathogens. Show less

The University of Kansas

United States
Higher Education
700 & Above Employee

Postdoctoral Research Scientist - IRACDA Fellow
- Aug 2017 - Jun 2021
Determining the pathogenic molecule(s) responsible for Alzheimer’s disease, utilizing molecular and cellular biology techniques. Specialized experience in neuronal cell culture (SH-SY5Y, N2a), cloning, CRISPR gene editing, DNA mutagenesis, ELISA protein quantification, western blotting including hand cast long bicine/urea gels for protein separation, qRT-PCR, PCR gel electrophoresis, and mitochondrial function testing using Seahorse instruments. Collaborated and maintained cell lines between two different laboratories in different cities. Characterized novel antibodies for the detection of beta-amyloid of different lengths. Show less

University of Connecticut

United States
Higher Education
700 & Above Employee

Graduate Student Research Assistant
- Aug 2012 - Jul 2017
Dissertation: The role of H19, a long non-coding RNA, in liver development.Trained in pharmacology and toxicology with experience in molecular and cellular biology, focused in genetics. Utilized techniques including qRT-PCR, western blot, ChIP, cloning, immunohistochemistry, transfection, and RNA-sequencing pipeline as well as proper sterile technique culturing primary cells and immortalized cell lines including HepaRG and HepG2. Animal work included knockout mouse models with complex breeding schemes, genotyping including primer design, PCR gel electrophoresis, mouse surgery survival ischemia/reperfusion and non-survival liver cell isolation, IP and tail vein IV injections. Extensive writing experience in scientific protocols, regulatory (IACUC), journal articles, and grant submissions. Effective oral communicator presenting in seminar series and at scientific conferences. Show less
Graduate Teaching Assistant
- Jan 2014 - Dec 2014
Presented and attended lectures. Met with students regarding coursework and class administration. Assisted professors with exam preparation and proctoring.

University of Kansas Medical Center

Higher Education
700 & Above Employee

Graduate Student Research Assistant
- Aug 2011 - Aug 2012
Graduated from Interdisciplinary Graduate Program in Biomedical Sciences. Attended lectures, presented research, rotated through three different laboratories in the Department of Pharmacology & Toxicology. Facilitated move of laboratory from Kansas to Connecticut Graduated from Interdisciplinary Graduate Program in Biomedical Sciences. Attended lectures, presented research, rotated through three different laboratories in the Department of Pharmacology & Toxicology. Facilitated move of laboratory from Kansas to Connecticut

XenoTech, A BioIVT Company

United States
Pharmaceutical Manufacturing
1 - 100 Employee

R&D Core Scientist II
- May 2005 - Aug 2011
R&D Core - Focused on improving the process of isolating and maintaining hepatocytes through R&D efforts. Led various projects including utilizing apoptosis inhibitors, optimizing plating surfaces to increase cryopreserved hepatocyte attachment, testing assays for cell quantification, and co-cultures with hepatocytes, fibroblasts, and Kupffer cells. Improved new products including hepatocyte suspensions for drug metabolism studies. Developed new assays for use in-house. Cross-trained in various departments with experience in qRT-PCR, Drug Inhibition involving automated assays using subcellular fractions, and Enzyme Induction utilizing hepatocytes in culture. Production -Lead Scientist for the preparation and characterization of subcellular fractions. Followed GLP practices and regulations with report preparation and data verification. Utilized microtiter plate reader and cuvette spectrophotometer, automated liquid handling workstations, and HPLC equipment for characterization assays. Performed non-survival surgery on rodents for organ harvest. Worked with human livers for cell isolation and cryopreservation. Show less
Production Research Assistant
- May 2005 - Jul 2006
Lead Scientist for the preparation and characterization of subcellular fractions. Followed GLP practices and regulations. Utilized microtiter plate reader, spectrophotometer, automated liquid handling workstations, and HPLC equipment for characterization assays. Performed non-survival surgery on rodents for organ harvest. Report preparation and data verification for finished products. Handled general lab maintenance, solution preparation, and purchasing of supplies and equipment. Member of the liver perfusion on-call team as Products Cell Isolation and Plating Expert working with human liver tissue for cryopreservation and plating. Show less

Celliance Corporation

Biotechnology
1 - 100 Employee

Manufacturing Technician
- Nov 2004 - Mar 2005
Assisted in the formulation of reagents and product assembly for EX-CYTE, a growth enhancement media supplement. Followed GMP regulations and practices. Produced and maintained batch reports and other protocol documentation. Participated in in-process testing and quality control. Assisted in the formulation of reagents and product assembly for EX-CYTE, a growth enhancement media supplement. Followed GMP regulations and practices. Produced and maintained batch reports and other protocol documentation. Participated in in-process testing and quality control.

Pearson Clinical Assessments

United States
Mental Health Care
200 - 300 Employee

Customer Service Representative
- May 2004 - Nov 2004
Answered questions regarding Medicare and inform beneficiaries of current and upcoming changes in Medicare coverage. Provided helpful referrals and offered assistance with finding pharmaceutical assistance programs available based on eligibility. Answered questions regarding Medicare and inform beneficiaries of current and upcoming changes in Medicare coverage. Provided helpful referrals and offered assistance with finding pharmaceutical assistance programs available based on eligibility.