Experience

Synendos Therapeutics AG

• Switzerland
• Pharmaceutical Manufacturing
• 1 - 100 Employee

• R&D Project Manager Neuroscience

  • Jan 2023 - Present



Endogena Therapeutics, Inc.

• Switzerland
• Biotechnology Research
• 1 - 100 Employee

• Principal Scientist

  • Jul 2021 - Dec 2022

  Lead and manage small molecule drug discovery efforts around idiopathic pulmonary fibrosis and regeneration• Build in-house wet-lab capabilities including purchasing equipment and hiring personnel• Set up molecular and cellular assays for compound screening and hit identification and optimization• Management of CRO outsourcing strategies to maximize project success, accelerate research andmeet timelines• Establish and negotiate scientific collaborations with KOLs Lead and manage small molecule drug discovery efforts around idiopathic pulmonary fibrosis and regeneration• Build in-house wet-lab capabilities including purchasing equipment and hiring personnel• Set up molecular and cellular assays for compound screening and hit identification and optimization• Management of CRO outsourcing strategies to maximize project success, accelerate research andmeet timelines• Establish and negotiate scientific collaborations with KOLs



Cairn Biosciences

• United States
• Biotechnology Research
• 1 - 100 Employee

• Scientist

  • Mar 2020 - May 2021

  Establish Cairn’s proprietary drug discovery platform• Integrate reporter cell line engineering (e.g. hiPSC, immortalized cell lines) with advanced tissue culture and high content imaging for phenotypic profiling• Apply platform to support drug discovery in the field of acquired resistance to targeted cancer therapies as well as for the profiling of compounds in the neuro space• Principal investigator and lead of a NIH Small Business Innovation Research grant• Training and supervision of direct reports, close collaboration with engineers and data scientist to build a machine-learning enabled image analysis pipeline.• Management of CRO outsourcing strategies to maximize project success, accelerate research and meet timelines• Streamline lab organization by implementation of new lab management software and staff training



BioElectron Technology Corporation

• Scientist II

  • Jul 2019 - Jul 2019

  • Establish engineered cellular models for specific genetically-determined protein neuropathies. Performed compound screens with these model systems on the ArrayScan platform.• Profound expertise in Alzheimer's Disease, Parkinson's Disease, as well as metabolic disease and mitochondrial disease areas.

• Scientist I

  • Nov 2017 - Jun 2019

  • Lead scientist accountable for establishing genetic evidence of mechanism of action for the clinical-stage compound EPI-743 in protecting against ferroptotic cell death.• Expanded siRNA target validation screens to primary patient-derived fibroblasts. Coupled with high-throughput microscopy endpoints, these studies provided rich quantitative evidence of mechanism of action for lead compound.• Developed a strategic framework and tractable screening assays for a lead optimization campaign in metabolic disease.• Collaborated extensively with the Bioanalytical team to design, execute and analyze LC-MS/MS metabolomics profiling in support of translational biomarker discovery• Established rodent primary astrocyte and microglial culture systems to assay pre-clinical candidate small molecules for neuroinflammation indication.• Supervised research associates to execute complex projects.



Howard Hughes Medical Institute

• United States
• Research Services
• 700 & Above Employee

• Research Specialist

  • Jan 2013 - Oct 2017

  Project: The role of THO complex in presynaptic gene expression and synapse assembly• Visual forward genetic screens, suppressor and enhancer screens to identify the underlying molecular pathways of THO complex in presynaptic gene expression• RNAseq of FACS sorted neuronal sub populations, qPCR, single molecule FISH• Initiated national and international collaborations with leading research groups at Stanford and University College London, UK Project: The role of THO complex in presynaptic gene expression and synapse assembly• Visual forward genetic screens, suppressor and enhancer screens to identify the underlying molecular pathways of THO complex in presynaptic gene expression• RNAseq of FACS sorted neuronal sub populations, qPCR, single molecule FISH• Initiated national and international collaborations with leading research groups at Stanford and University College London, UK



Stanford University

• United States
• Higher Education
• 700 & Above Employee

• Postdoc Research Scientist

  • 2008 - 2012

  Project: In vivo quantitative analysis of synaptic vesicle trafficking regulation• Established a non invasive high resolution microscopy assay to follow trafficking of synaptic components in neurons• Highly collaborative project within the lab resulting in multiple high impact publications• Maintained equipment and trained scientific staff Project: In vivo quantitative analysis of synaptic vesicle trafficking regulation• Established a non invasive high resolution microscopy assay to follow trafficking of synaptic components in neurons• Highly collaborative project within the lab resulting in multiple high impact publications• Maintained equipment and trained scientific staff



EMBL

• Germany
• Research Services
• 700 & Above Employee

• Postdoctoral Fellow

  • 2007 - 2008

• PHD

  • 2003 - 2007

  Project: Quantitative Imaging of MAPK-Scaffold Complexes in Yeast Pheromone Signaling• Established Fluorescence Cross-/Correlation Spectroscopy (FCS/FCCS) in yeast for the quantification of endogenous protein complexes.• Visualization of protein phosphorylation gradients by immunohistochemistry(IHC) followed by Fluorescence Lifetime Imaging (FLIM) • Leadership in highly interdisciplinary project including physicists and spectroscopists



University of Basel

• Switzerland
• Research Services
• 700 & Above Employee

• Master of Science

  • 2002 - 2003

  Project: Characterization of the Bul1-Rsp5 protein ubiquitin ligase complex in S.cerevisiaeLarge scale purification of Bul1-Rsp5 protein complexes for mass spectrometry analysis Basic training in molecular biology, biochemistry, cell biology and genetics. Project: Characterization of the Bul1-Rsp5 protein ubiquitin ligase complex in S.cerevisiaeLarge scale purification of Bul1-Rsp5 protein complexes for mass spectrometry analysis Basic training in molecular biology, biochemistry, cell biology and genetics.