Catarina Brito
Principal Investigator at ITQB NOVA- Claim this Profile
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Bio
Experience
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ITQB NOVA
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Portugal
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Higher Education
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100 - 200 Employee
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Principal Investigator
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Feb 2023 - Present
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PI, Advanced Cell Models Lab
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2015 - Present
PI of the Advanced Cell Models LabTechnology Division
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iBET - Instituto de Biologia Experimental e Tecnológica
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Portugal
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Biotechnology Research
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100 - 200 Employee
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Head of Lab, Advanced Cell Models
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2014 - Present
Our research is mostly translational and focused on the study of the cel microenvironment in disease progression and drug response. To address these issues we develop and employ advanced cell-based disease models using stem cells and other patient-derived cells, and exploring three-dimensional co-culture strategies, along with cell biological and biochemical approaches. Our main research targets are Central Nervous System diseases and Cancer.
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Senior Scientist
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Jul 2009 - Dec 2013
Animal Cell Technology UnitAs a senior scientist and project manager, I’ve worked in academic and industry funded projects focused focused mainly on development of in vitro models for Pre-Clinical Research and assay development. The main objective of the work was to develop tri-dimensional (3D) cell culture systems that, by better mimicking the cellular environment of the human organism, will facilitate the integration of data from pre-clinical assays in drug discovery and toxicology areas, allowing for a reduction in the number of animal experiments and contributing to the fast approval and release of biopharmaceuticals into the market. The focus was mainly on neural and hepatic toxicology. Show less
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Post-doc fellow
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Aug 2007 - Jun 2009
Animal Cell Technology UnitAs a post-doctoral fellow I have worked on the development of new tri-dimensional (3D)-culture systems for clinical-relevant cells for cell therapy and pre-clinical research applications. These included stem cell expansion and differentiation using scalable stirred-tank bioreactors and cryopreservation.
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PhD student
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2003 - 2007
Laboratory of Glycobiology My PhD thesis focused on the elucidation of the role of specific protein carbohydrate moieties in human neuronal differentiation and neuronal trafficking, and on exploring the utilization of glycosyltransferases for synthetic applications. During my time at Laboratory of Glycobiology, I was involved in several projects, covering areas such as protein glycosylation, intracellular protein traffic in mammalian cells; glycosylation and cancer; neuronal differentiation and neuritogenesis. Show less
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Institut Jacques Monod/CNRS
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France
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Research
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1 - 100 Employee
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Visiting PhD Student
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2006 - 2006
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Junior Researcher
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2001 - 2002
Laboratory of Glycobiology
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Undergraduate Student
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2000 - 2001
Laboratory of Glycobiology
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Education
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Universidade Nova de Lisboa
PhD, Biochemistry -
University of Lisbon
5-year degree, Biochemistry