Benjamin McMichael
PHD Student at University of North Carolina at Chapel Hill- Claim this Profile
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English Native or bilingual proficiency
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Spanish Limited working proficiency
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Bio
Experience
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University of North Carolina at Chapel Hill
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United States
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Higher Education
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700 & Above Employee
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PHD Student
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Aug 2022 - Present
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Research Technician
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Jul 2021 - Jul 2022
Analyzed amplicon sequencing data using bioinformatic RNA conformation prediction tools to compare predicted RNA conformations and elucidate possible functional consequences.Analyzed bulk RNA-seq data of histone mutant Drosophila brains to determine differential splicing.Designed and performed an assay to determine the efficacy of experimental drugs in reducing the phenotypic effects of SMN mutations in Drosophila.
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US Environmental Protection Agency (EPA)
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United States
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Government Administration
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700 & Above Employee
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ORISE Research Fellow
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Jan 2020 - Jul 2021
Utilized the EPA ToxCast database to evaluate chemical toxicity. This database contains high-throughput (HTP) screening data on over 4000 chemicals which have been tested in any number of over 700 different assays. Evaluated the effect of maternal thyroid hormone insufficiency on brain development through differential gene expression analysis of neonatal ventricular epithelium by RNA-sequencing. Utilized the EPA ToxCast database to evaluate chemical toxicity. This database contains high-throughput (HTP) screening data on over 4000 chemicals which have been tested in any number of over 700 different assays. Evaluated the effect of maternal thyroid hormone insufficiency on brain development through differential gene expression analysis of neonatal ventricular epithelium by RNA-sequencing.
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Clemson University
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United States
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Higher Education
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700 & Above Employee
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Graduate Research And Teaching Assistant
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Aug 2017 - Dec 2019
Examined the effects of developmental As exposure below the current drinking water standard (10 ppb) by utilizing P19 pluripotent mouse carcinoma cells. Analyzed differential gene and protein expression, as well as changes in transcription factor translocation, to delineate molecular mechanisms leading to alterations in cell fate determination and pluripotency maintenance. Trained fellow graduate and undergraduate students on techniques including cell culture, PCR, qPCR, RNA extraction, protein extraction, western blot, immunohistochemistry (IHC), and cDNA synthesis. Show less
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Florida State University
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United States
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Higher Education
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700 & Above Employee
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Undergraduate Research Assistant
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May 2014 - Dec 2014
Worked as an assistant conducting research on the effects of brain-derived neurotrophic factor (BDNF) on the learning deficits of cocaine induced mice. Assessed the use of a selective TrkB antagonist to improve the ability of prenatally cocaine exposed mice to reverse learn tasks. Operated an olfactometer to operantly condition mice to associate a specific odor with a reward. Worked as an assistant conducting research on the effects of brain-derived neurotrophic factor (BDNF) on the learning deficits of cocaine induced mice. Assessed the use of a selective TrkB antagonist to improve the ability of prenatally cocaine exposed mice to reverse learn tasks. Operated an olfactometer to operantly condition mice to associate a specific odor with a reward.
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Education
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University of North Carolina at Chapel Hill
Doctor of Philosophy - PhD, Molecular Biology -
Clemson University
Master of Science - MS, Biology -
Florida State University
Bachelor's degree, Biology