Benjamin McMichael

PHD Student at University of North Carolina at Chapel Hill
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Contact Information
us****@****om
(386) 825-5501
Location
Chapel Hill, North Carolina, United States, US
Languages
  • English Native or bilingual proficiency
  • Spanish Limited working proficiency

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Experience

    • United States
    • Higher Education
    • 700 & Above Employee
    • PHD Student
      • Aug 2022 - Present

    • Research Technician
      • Jul 2021 - Jul 2022

      Analyzed amplicon sequencing data using bioinformatic RNA conformation prediction tools to compare predicted RNA conformations and elucidate possible functional consequences.Analyzed bulk RNA-seq data of histone mutant Drosophila brains to determine differential splicing.Designed and performed an assay to determine the efficacy of experimental drugs in reducing the phenotypic effects of SMN mutations in Drosophila.

    • United States
    • Government Administration
    • 700 & Above Employee
    • ORISE Research Fellow
      • Jan 2020 - Jul 2021

      Utilized the EPA ToxCast database to evaluate chemical toxicity. This database contains high-throughput (HTP) screening data on over 4000 chemicals which have been tested in any number of over 700 different assays. Evaluated the effect of maternal thyroid hormone insufficiency on brain development through differential gene expression analysis of neonatal ventricular epithelium by RNA-sequencing. Utilized the EPA ToxCast database to evaluate chemical toxicity. This database contains high-throughput (HTP) screening data on over 4000 chemicals which have been tested in any number of over 700 different assays. Evaluated the effect of maternal thyroid hormone insufficiency on brain development through differential gene expression analysis of neonatal ventricular epithelium by RNA-sequencing.

    • United States
    • Higher Education
    • 700 & Above Employee
    • Graduate Research And Teaching Assistant
      • Aug 2017 - Dec 2019

      Examined the effects of developmental As exposure below the current drinking water standard (10 ppb) by utilizing P19 pluripotent mouse carcinoma cells. Analyzed differential gene and protein expression, as well as changes in transcription factor translocation, to delineate molecular mechanisms leading to alterations in cell fate determination and pluripotency maintenance. Trained fellow graduate and undergraduate students on techniques including cell culture, PCR, qPCR, RNA extraction, protein extraction, western blot, immunohistochemistry (IHC), and cDNA synthesis. Show less

    • United States
    • Higher Education
    • 700 & Above Employee
    • Undergraduate Research Assistant
      • May 2014 - Dec 2014

      Worked as an assistant conducting research on the effects of brain-derived neurotrophic factor (BDNF) on the learning deficits of cocaine induced mice. Assessed the use of a selective TrkB antagonist to improve the ability of prenatally cocaine exposed mice to reverse learn tasks. Operated an olfactometer to operantly condition mice to associate a specific odor with a reward. Worked as an assistant conducting research on the effects of brain-derived neurotrophic factor (BDNF) on the learning deficits of cocaine induced mice. Assessed the use of a selective TrkB antagonist to improve the ability of prenatally cocaine exposed mice to reverse learn tasks. Operated an olfactometer to operantly condition mice to associate a specific odor with a reward.

Education

  • University of North Carolina at Chapel Hill
    Doctor of Philosophy - PhD, Molecular Biology
    2022 - 2027
  • Clemson University
    Master of Science - MS, Biology
    2017 - 2019
  • Florida State University
    Bachelor's degree, Biology
    2012 - 2016

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