Barrie Martin
Director of Chemistry and Conformational Design at C4X Discovery Ltd- Claim this Profile
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Bio
James Crawford
I worked with Barrie Martin during my time at AstraZeneca in a early stage / hit identification group. Barrie was a peer, colleague and friend, who impressed me greatly with his knowledge, work ethic and spirit. During one high priority chemokine inhibitor medicinal chemistry programme, Barrie spotted a previously neglected singleton hit compound that he was subsequently able to develop and progress into the AZ project portfolio, shortly before the closure of the R&D group at Charnwood. Who knows where this attractive (yet toxic) lead may have led were that not the case. He also took up cycling during our short tenure working together, which was a big hit. This turn to fitness also had an impact on his exceedingly strong levels of lab productivity. Barrie was an almost universally well-respected colleague at AZ, and I have followed his career as he made a bold move to Conformetrix/C4X where he took on the crucial role of 'Chief Chemist' and led their early medicinal chemistry efforts & applications of their technology. This led to a number of collaborative efforts with Genentech, and the company has gone from strength to strength since then. This was no surprise to me, chiefly since they have scientists such as Barrie at the helm. I would wholeheartedly recommend Barrie for medicinal chemistry and project leadership roles.
John Dixon
Barrie is a practising medicinal chemist who has worked on many drug discovery projects over several years and in several companies. His experience in the modern aspects of Medicinal Chemistry coupled with strong productivity will make him an asset to any organisation.
James Crawford
I worked with Barrie Martin during my time at AstraZeneca in a early stage / hit identification group. Barrie was a peer, colleague and friend, who impressed me greatly with his knowledge, work ethic and spirit. During one high priority chemokine inhibitor medicinal chemistry programme, Barrie spotted a previously neglected singleton hit compound that he was subsequently able to develop and progress into the AZ project portfolio, shortly before the closure of the R&D group at Charnwood. Who knows where this attractive (yet toxic) lead may have led were that not the case. He also took up cycling during our short tenure working together, which was a big hit. This turn to fitness also had an impact on his exceedingly strong levels of lab productivity. Barrie was an almost universally well-respected colleague at AZ, and I have followed his career as he made a bold move to Conformetrix/C4X where he took on the crucial role of 'Chief Chemist' and led their early medicinal chemistry efforts & applications of their technology. This led to a number of collaborative efforts with Genentech, and the company has gone from strength to strength since then. This was no surprise to me, chiefly since they have scientists such as Barrie at the helm. I would wholeheartedly recommend Barrie for medicinal chemistry and project leadership roles.
John Dixon
Barrie is a practising medicinal chemist who has worked on many drug discovery projects over several years and in several companies. His experience in the modern aspects of Medicinal Chemistry coupled with strong productivity will make him an asset to any organisation.
James Crawford
I worked with Barrie Martin during my time at AstraZeneca in a early stage / hit identification group. Barrie was a peer, colleague and friend, who impressed me greatly with his knowledge, work ethic and spirit. During one high priority chemokine inhibitor medicinal chemistry programme, Barrie spotted a previously neglected singleton hit compound that he was subsequently able to develop and progress into the AZ project portfolio, shortly before the closure of the R&D group at Charnwood. Who knows where this attractive (yet toxic) lead may have led were that not the case. He also took up cycling during our short tenure working together, which was a big hit. This turn to fitness also had an impact on his exceedingly strong levels of lab productivity. Barrie was an almost universally well-respected colleague at AZ, and I have followed his career as he made a bold move to Conformetrix/C4X where he took on the crucial role of 'Chief Chemist' and led their early medicinal chemistry efforts & applications of their technology. This led to a number of collaborative efforts with Genentech, and the company has gone from strength to strength since then. This was no surprise to me, chiefly since they have scientists such as Barrie at the helm. I would wholeheartedly recommend Barrie for medicinal chemistry and project leadership roles.
John Dixon
Barrie is a practising medicinal chemist who has worked on many drug discovery projects over several years and in several companies. His experience in the modern aspects of Medicinal Chemistry coupled with strong productivity will make him an asset to any organisation.
James Crawford
I worked with Barrie Martin during my time at AstraZeneca in a early stage / hit identification group. Barrie was a peer, colleague and friend, who impressed me greatly with his knowledge, work ethic and spirit. During one high priority chemokine inhibitor medicinal chemistry programme, Barrie spotted a previously neglected singleton hit compound that he was subsequently able to develop and progress into the AZ project portfolio, shortly before the closure of the R&D group at Charnwood. Who knows where this attractive (yet toxic) lead may have led were that not the case. He also took up cycling during our short tenure working together, which was a big hit. This turn to fitness also had an impact on his exceedingly strong levels of lab productivity. Barrie was an almost universally well-respected colleague at AZ, and I have followed his career as he made a bold move to Conformetrix/C4X where he took on the crucial role of 'Chief Chemist' and led their early medicinal chemistry efforts & applications of their technology. This led to a number of collaborative efforts with Genentech, and the company has gone from strength to strength since then. This was no surprise to me, chiefly since they have scientists such as Barrie at the helm. I would wholeheartedly recommend Barrie for medicinal chemistry and project leadership roles.
John Dixon
Barrie is a practising medicinal chemist who has worked on many drug discovery projects over several years and in several companies. His experience in the modern aspects of Medicinal Chemistry coupled with strong productivity will make him an asset to any organisation.
Experience
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C4X Discovery Ltd
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United Kingdom
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Pharmaceutical Manufacturing
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1 - 100 Employee
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Director of Chemistry and Conformational Design
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May 2022 - Present
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Senior Programme Manager
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Sep 2014 - Jun 2022
Project Leader on early and late stage Drug Discovery projects covering multi CRO to fully integrated outsourcing models; managing internal & external multidisciplinary teams.Lead Chemist for Drug Development projects supporting all CMC activities, including IMPD preparation & liasing with Consultants & Industry Experts.Chemistry lead for partnering discussions with support for Due Diligence and information/data transfer.
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Chief Medicinal Chemist
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Mar 2012 - Sep 2014
Development of applications & demonstration of the impact of Conformetrix technology within internal and partner Drug Discovery projects.Building the C4X discovery department through identification & recruitment of a team of highly experienced scientists.
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Medicinal Chemist
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Jul 2011 - Mar 2012
Principal Drug Discovery scientist at the University of Manchester Biotech spin-out company, Conformetrix (C4XDiscovery). Identifying Medicinal Chemistry insights from, and applications of the experimentally determined solution behaviour of bioactive small molecules.Initiation of internal Drug Discovery projects & providing expert analysis for partner projects.
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University of Manchester
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United Kingdom
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Aviation and Aerospace Component Manufacturing
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1 - 100 Employee
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Visiting Scientist
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Aug 2011 - Jun 2019
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AstraZeneca
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United Kingdom
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Pharmaceutical Manufacturing
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700 & Above Employee
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Lead Generation Project Lead
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Sep 2008 - Jul 2011
Invited to be a founder member of a team of experienced medicinal chemists. Responsible for delivering projects from HTS and fast follower start points. The role combined project and design experience from past candidate drug delivery.
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Lead Chemist Medicinal Chemistry
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Sep 2003 - Sep 2008
Introduction of increased project responsibilities following successful series optimisation and candidate drug delivery for multiple projects.
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Senior Research Scientist
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Sep 1999 - Sep 2003
Increased medicinal chemistry role and supervisor/line manager responsibilities, following successful delivery of many synthetically challenging targets and scale-ups.
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Astra Pharmaceuticals
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Pharmaceutical Manufacturing
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100 - 200 Employee
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Senior Research Scientist
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Sep 1995 - Sep 1999
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Fisons Pharmaceuticals
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India
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Mining
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1 - 100 Employee
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Research Scientist
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Sep 1993 - Sep 1995
Recruited as an experienced graduate chemist. Independently responsible for synthetic design to pertinent targets, with increasing target design. Recruited as an experienced graduate chemist. Independently responsible for synthetic design to pertinent targets, with increasing target design.
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Boots Pharmaceuticals
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Uganda
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Wholesale Drugs and Sundries
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Research Scientist
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Jun 1986 - Sep 1993
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Education
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1997 - 2000
University of East Anglia
MSc, Chemistry -
1986 - 1991
Nottingham Trent University
BSc, Chemistry -
1984 - 1986
South Notts College of FE
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1979 - 1984
Farnborough Comprehensive
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