Ariana Umana
Scientist at Rise Therapeutics- Claim this Profile
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Spanish Native or bilingual proficiency
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Portuguese Elementary proficiency
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English Native or bilingual proficiency
Topline Score
Bio
Credentials
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Principles of Preclinical Translational Science
National Center for Advancing Translational Sciences (NCATS)May, 2022- Nov, 2024
Experience
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Rise Therapeutics
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United States
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Biotechnology Research
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1 - 100 Employee
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Scientist
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Jan 2023 - Present
Lead new drug development strategies for synthetic biology-based cellular medicines Develop and characterize novel microbiome drug candidates Perform analytical testing procedures for product characterization Develop new microbiology genetic modification systems and scientific assessment procedures Analyzing data to identify limitations and bottlenecks in the performance of your microbes and designing strains in silico based on the above Support discovery and development of new functionally-directed bacteria strains Author SOPs, reports, and other controlled documents important for IND filings
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National Human Genome Research Institute (NHGRI)
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United States
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Research
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200 - 300 Employee
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Postdoctoral Researcher
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Jan 2021 - Dec 2022
· Explored the role of somatic mutations in endometrial carcinomas (EC) with a focus on the functional characterization of nonsynonymous missense mutations within the TGFβ signaling pathway. · Characterized the role of somatic mutations in R-SMADs that mediate Transforming Growth Factor Beta Receptor 1 (TβR-I) signaling and how they contribute to tumorigenesis through in-silico analysis, biochemical and cell-based assays, while exploring them as druggable targets. · Performed molecular dynamics simulations to predict protein-protein interactions of R-SMAD, co-SMAD and TβR-I.
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Virginia Tech
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United States
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Higher Education
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700 & Above Employee
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Graduate Student Researcher at The Slade Lab
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Aug 2016 - Dec 2020
· Focused on host-pathogen interaction to study invasion, infection and signaling on colorectal cancer. · Employed experimental and bioinformatic approaches to characterize the role of bacterial outer membrane and secreted proteins of Fusobacterium nucleatum diseases. · Established FusoPortal, an online database of Fusobacterium genomes (www.fusportal.org) · Discovered and utilized DNA methyltransferases in Fusobacterium nucleatum to enhance bacterial genetics and transformation efficiency in Fusobacterium strains. · Developed protocols for mutant constructions, protein expression and purification of large secreted Type V autotransporters and outer membrane proteins. · Supervised and managed projects for undergraduates and graduate students who rotated through the lab. · Coordinated all ordering of supplies and ensured adequate maintenance of research requirements.
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Hospira
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United States
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Pharmaceutical Manufacturing
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700 & Above Employee
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BQ technician
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Oct 2015 - Jun 2016
· Performed routine environmental monitoring of the GMP manufacturing facility · Conducted microbiological testing (microbial limits validation, bioburden, bacterial endotoxin, water testing) of incoming raw materials, in-process product solutions, and final products. · Completed biological testing (particulate matter test) of finished products. · Read and interpret Standard Operational procedures and test methods for medical devices. ·Reported testing results through standard laboratory based systems.
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Education
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2016 - 2020
Virginia Tech
Doctor of Philosophy - PhD, Biochemistry -
2011 - 2015
Tecnológico de Costa Rica
Bachelor's degree, Bioctechnology Engineering
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