Antonio Varone
Principal Scientist at Emulate, Inc.- Claim this Profile
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Bio
Experience
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Emulate, Inc.
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Biotechnology Research
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1 - 100 Employee
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Principal Scientist
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Jul 2018 - Present
I am a highly motivated and creative Biomedical Engineer with 6 years of extensive research experience in designing, development and characterization of in vitro 3D pre-clinical human models for investigative toxicology studies. In my scientific career, I led a team of both experienced and junior scientists in a number of pharmacological studies intended to identify clinically-relevant biomarkers, to investigate the mechanisms of toxicity of novel compounds for immune-oncology and autoimmunity… Show more I am a highly motivated and creative Biomedical Engineer with 6 years of extensive research experience in designing, development and characterization of in vitro 3D pre-clinical human models for investigative toxicology studies. In my scientific career, I led a team of both experienced and junior scientists in a number of pharmacological studies intended to identify clinically-relevant biomarkers, to investigate the mechanisms of toxicity of novel compounds for immune-oncology and autoimmunity application with the overall goal of enhancing the effectiveness of drug discovery and development. I also supervised the development of based screens assays using microfluidic device. As a leader, I promote an empowered and accountable culture and believe in the power of collaboration. I have an immediate impact on any organization that I join through my relentless work, energy and drive for rigor and delivery.
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Senior Scientist
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Jul 2017 - Jul 2018
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University of Pennsylvania
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United States
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Higher Education
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700 & Above Employee
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Science Research Specialist
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Jan 2016 - Jul 2017
Organ-on-Chip project: designed a biomimetic microfluidic chip based on “Organ-Chip” technology that reconstitutes a functionally active epithelial-connective tissue interface of the human organs. This bioinspired organ-chip platform integrates complex organ-level functionalities such as peristaltic-like mechanical strain (stretching) and active flow. The platform which provides controllable mechanical strain helping the investigation of the force-related aspects of cell morphogenesis, cell… Show more Organ-on-Chip project: designed a biomimetic microfluidic chip based on “Organ-Chip” technology that reconstitutes a functionally active epithelial-connective tissue interface of the human organs. This bioinspired organ-chip platform integrates complex organ-level functionalities such as peristaltic-like mechanical strain (stretching) and active flow. The platform which provides controllable mechanical strain helping the investigation of the force-related aspects of cell morphogenesis, cell movements and cell-cell interactions. The chip has a controllable active flow interconnecting epithelial, mesenchymal and endothelial cells which lead to a better understanding of the underlying molecular mechanisms of molecule uptake, transport and metabolism of both nutrient and drug compounds creating a more sophisticated organ models for tissue engineering, in vitro drug development and drug pharmaco-kinetic applications. Show less Organ-on-Chip project: designed a biomimetic microfluidic chip based on “Organ-Chip” technology that reconstitutes a functionally active epithelial-connective tissue interface of the human organs. This bioinspired organ-chip platform integrates complex organ-level functionalities such as peristaltic-like mechanical strain (stretching) and active flow. The platform which provides controllable mechanical strain helping the investigation of the force-related aspects of cell morphogenesis, cell… Show more Organ-on-Chip project: designed a biomimetic microfluidic chip based on “Organ-Chip” technology that reconstitutes a functionally active epithelial-connective tissue interface of the human organs. This bioinspired organ-chip platform integrates complex organ-level functionalities such as peristaltic-like mechanical strain (stretching) and active flow. The platform which provides controllable mechanical strain helping the investigation of the force-related aspects of cell morphogenesis, cell movements and cell-cell interactions. The chip has a controllable active flow interconnecting epithelial, mesenchymal and endothelial cells which lead to a better understanding of the underlying molecular mechanisms of molecule uptake, transport and metabolism of both nutrient and drug compounds creating a more sophisticated organ models for tissue engineering, in vitro drug development and drug pharmaco-kinetic applications. Show less
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Emulate, Inc.
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Biotechnology Research
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1 - 100 Employee
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Scientist II
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Jan 2015 - Jan 2016
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Wyss Institute at Harvard University
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United States
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Biotechnology Research
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200 - 300 Employee
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Research Assistant at Wyss Institute at Harvard University
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Mar 2014 - Jan 2015
Organ-on-Chip projects: Lung on a Chip is a complex, three-dimensional model of a living, breathing human lung on a microchip. The device is made using human lung and blood vessel cells and it can predict absorption of airborne nanoparticles and mimic the inflammatory response triggered by microbial pathogens. It can be used to test the effects of environmental toxins, absorption of aerosolized therapeutics, and the safety and efficacy of new drugs. It is expected to become an alternative to… Show more Organ-on-Chip projects: Lung on a Chip is a complex, three-dimensional model of a living, breathing human lung on a microchip. The device is made using human lung and blood vessel cells and it can predict absorption of airborne nanoparticles and mimic the inflammatory response triggered by microbial pathogens. It can be used to test the effects of environmental toxins, absorption of aerosolized therapeutics, and the safety and efficacy of new drugs. It is expected to become an alternative to animal testing Show less Organ-on-Chip projects: Lung on a Chip is a complex, three-dimensional model of a living, breathing human lung on a microchip. The device is made using human lung and blood vessel cells and it can predict absorption of airborne nanoparticles and mimic the inflammatory response triggered by microbial pathogens. It can be used to test the effects of environmental toxins, absorption of aerosolized therapeutics, and the safety and efficacy of new drugs. It is expected to become an alternative to… Show more Organ-on-Chip projects: Lung on a Chip is a complex, three-dimensional model of a living, breathing human lung on a microchip. The device is made using human lung and blood vessel cells and it can predict absorption of airborne nanoparticles and mimic the inflammatory response triggered by microbial pathogens. It can be used to test the effects of environmental toxins, absorption of aerosolized therapeutics, and the safety and efficacy of new drugs. It is expected to become an alternative to animal testing Show less
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Tufts University
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United States
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Higher Education
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700 & Above Employee
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Reaseach Assistant
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Aug 2010 - Mar 2014
Organotypic epithelium equivalent expressing HPV oncoproteins project: Engineered artificial organotypic epithelia expressing HPV oncoproteins are complex, three-dimensional model of a living, human skin capable of reproducing the differentiation-dependent replication cycle of human papillomavirus (HPV). The human in vitro organotypic culture was investigated using Two-Photon Fluorescence and Second Harmonic Generation high-resolution, depth-resolved imaging, relying entirely on endogenous… Show more Organotypic epithelium equivalent expressing HPV oncoproteins project: Engineered artificial organotypic epithelia expressing HPV oncoproteins are complex, three-dimensional model of a living, human skin capable of reproducing the differentiation-dependent replication cycle of human papillomavirus (HPV). The human in vitro organotypic culture was investigated using Two-Photon Fluorescence and Second Harmonic Generation high-resolution, depth-resolved imaging, relying entirely on endogenous two-photon excited fluorescence in combination with invasive biochemical assays. Optical imaging relying on endogenous fluorescence has been used as a noninvasive approach to assess tissue metabolic changes during cancer development. Show less Organotypic epithelium equivalent expressing HPV oncoproteins project: Engineered artificial organotypic epithelia expressing HPV oncoproteins are complex, three-dimensional model of a living, human skin capable of reproducing the differentiation-dependent replication cycle of human papillomavirus (HPV). The human in vitro organotypic culture was investigated using Two-Photon Fluorescence and Second Harmonic Generation high-resolution, depth-resolved imaging, relying entirely on endogenous… Show more Organotypic epithelium equivalent expressing HPV oncoproteins project: Engineered artificial organotypic epithelia expressing HPV oncoproteins are complex, three-dimensional model of a living, human skin capable of reproducing the differentiation-dependent replication cycle of human papillomavirus (HPV). The human in vitro organotypic culture was investigated using Two-Photon Fluorescence and Second Harmonic Generation high-resolution, depth-resolved imaging, relying entirely on endogenous two-photon excited fluorescence in combination with invasive biochemical assays. Optical imaging relying on endogenous fluorescence has been used as a noninvasive approach to assess tissue metabolic changes during cancer development. Show less
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Education
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University of Crete
Doctor of Philosophy - PhD, Pharmacology -
Tufts University
Master of Science - MS, Biomedical/Medical Engineering -
Seconda Università degli Studi di Napoli
Bachelor of Applied Science - BASc, Biotechnology