Ann Marie K Weideman, M.S.
Predoctoral Trainee, Cancer Genomics Training Grant (T32) at University of North Carolina at Chapel Hill- Claim this Profile
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Bio
Experience
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University of North Carolina at Chapel Hill
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United States
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Higher Education
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700 & Above Employee
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Predoctoral Trainee, Cancer Genomics Training Grant (T32)
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Aug 2020 - Present
Supervisors: Joseph Ibrahim, Ph.D., Yuchao Jiang, Ph.D. • Construct Bayesian frameworks to infer tumor phylogenetic history and conduct mutational profiling of tumor subpopulations • Develop methodologies appropriate for the sparsity and stochasticity of single-cell data • Perform variant discovery on the Longleaf Cluster using popular tools for high-throughput sequencing data like Genome Analysis Toolkit (GATK), SAMtools, and Salmon
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Graduate Research Assistant, Center for AIDS Research (CFAR) Biostatistics Core
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Aug 2018 - Present
http://unccfar.org/portfolio/biostatistics/ Supervisor: Michael Hudgens, Ph.D. • Statistically support HIV/AIDS research networks with database management, statistical analysis plans and conduct, power and sample size calculations, safety monitoring committees, interim data monitoring, manuscripts, student mentoring, and exploratory/developmental grant applications • Statistician on phase I/II trials to evaluate the safety and immunogenicity of HIV-1 vaccines or combination… Show more http://unccfar.org/portfolio/biostatistics/ Supervisor: Michael Hudgens, Ph.D. • Statistically support HIV/AIDS research networks with database management, statistical analysis plans and conduct, power and sample size calculations, safety monitoring committees, interim data monitoring, manuscripts, student mentoring, and exploratory/developmental grant applications • Statistician on phase I/II trials to evaluate the safety and immunogenicity of HIV-1 vaccines or combination antiretroviral therapy (ART) • HIV-related work has also entailed adherence studies, rapid ART initiation, CD8 T cell metabolism and inhibition, regulation of HIV latency, dental and prosthodontic care in persons with HIV, and syphilis self-testing
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Grader, Graduate Biostatistics Courses
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Aug 2020 - Dec 2021
Courses graded: Analysis of Categorical Data, BIOS 665 · Fall 2021 Intermediate Statistical Methods, BIOS 662 · Fall 2020
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National Institutes of Health
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Research Services
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200 - 300 Employee
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Post-Baccalaureate Fellow, Neuroimmunological Diseases Section, NIAID
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Sep 2016 - Sep 2018
Supervisor: Bibiana Bielekova, M.D. • Statistically supported a team research effort to better understand the pathophysiology of central nervous system injury in order to develop effective therapies and treatment strategies for multiple sclerosis • Employed genetic algorithms, combined with parallel computing on the NIH Biowulf cluster, to develop an MRI disease rating scale • Beta tested a multiple sclerosis test suite (Android platform) and statistically validated outcomes from… Show more Supervisor: Bibiana Bielekova, M.D. • Statistically supported a team research effort to better understand the pathophysiology of central nervous system injury in order to develop effective therapies and treatment strategies for multiple sclerosis • Employed genetic algorithms, combined with parallel computing on the NIH Biowulf cluster, to develop an MRI disease rating scale • Beta tested a multiple sclerosis test suite (Android platform) and statistically validated outcomes from several simple functional tests
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Summer Fellow, Laboratory of Biological Modeling, NIDDK
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Jun 2016 - Sep 2016
Supervisor: Arthur Sherman, Ph.D. • Investigated how a G protein-coupled inwardly-rectifying potassium (GIRK) and transient receptor potential cation (TRP) channel affect electrical oscillations in pancreatic beta-cells • Developed a mathematical model of electrical activity in beta-cells, similar to the Hodgkin-Huxley model used to describe action potentials in neurons • Simulated the effects of glucagon-like peptide-1 (GLP-1) on signal transduction pathways
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Capitol Technology University
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Laurel, Maryland, United States
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Adjunct Faculty in Mathematics & Statistics
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Aug 2016 - May 2018
• Independently redesigned curriculum for MA-345, Probability and Statistics for Engineers, to incorporate R programming language and petitioned curriculum change to Probability & Statistics with R for Engineers and Scientists, 1st Edition. • Courses taught: Ordinary Differential Equations, MA-340 · Fall 2016, Spring 2017, Fall 2017, Spring 2018 Introduction to Statistics, MA-128 · Fall 2016, Fall 2017 Probability and Statistics for Engineers, MA-345 · Spring 2017, Spring 2018 • Independently redesigned curriculum for MA-345, Probability and Statistics for Engineers, to incorporate R programming language and petitioned curriculum change to Probability & Statistics with R for Engineers and Scientists, 1st Edition. • Courses taught: Ordinary Differential Equations, MA-340 · Fall 2016, Spring 2017, Fall 2017, Spring 2018 Introduction to Statistics, MA-128 · Fall 2016, Fall 2017 Probability and Statistics for Engineers, MA-345 · Spring 2017, Spring 2018
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Graduate Student Mathematical Modeling Camp
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Jun 2016 - Jun 2016
• Worked with a team of over 85 applied mathematicians, scientists, and junior researchers on mathematical problems in industry • RPI: Utilized two techniques, porosimetry and filtration efficiency, to better understand the properties of an ideal filter • Duke: Contributed to the development of an application that tracks patient asthma and COPD symptoms and recommends a course of action based on symptom severity • Worked with a team of over 85 applied mathematicians, scientists, and junior researchers on mathematical problems in industry • RPI: Utilized two techniques, porosimetry and filtration efficiency, to better understand the properties of an ideal filter • Duke: Contributed to the development of an application that tracks patient asthma and COPD symptoms and recommends a course of action based on symptom severity
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University of Maryland Baltimore County
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Baltimore, Maryland, United States
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Master’s Thesis
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Sep 2015 - May 2016
Mentor: Bradford Peercy, Ph.D. Thesis title: Modeling the pathogenesis of early-stage atherosclerosis following ionizing radiation exposure: a three-dimensional numerical study using COMSOL • Used a finite element analysis software (COMSOL) to model the three-dimensional pathogenesis of early-stage atherosclerosis following exposure to ionizing radiation • Solved a system of partial differential equations to predict rate of lesion formation following exposure to radiological incidents… Show more Mentor: Bradford Peercy, Ph.D. Thesis title: Modeling the pathogenesis of early-stage atherosclerosis following ionizing radiation exposure: a three-dimensional numerical study using COMSOL • Used a finite element analysis software (COMSOL) to model the three-dimensional pathogenesis of early-stage atherosclerosis following exposure to ionizing radiation • Solved a system of partial differential equations to predict rate of lesion formation following exposure to radiological incidents or radiation therapy • Discovered an increased risk of plaque development with radiation doses of over 2.2 Gray Show less Mentor: Bradford Peercy, Ph.D. Thesis title: Modeling the pathogenesis of early-stage atherosclerosis following ionizing radiation exposure: a three-dimensional numerical study using COMSOL • Used a finite element analysis software (COMSOL) to model the three-dimensional pathogenesis of early-stage atherosclerosis following exposure to ionizing radiation • Solved a system of partial differential equations to predict rate of lesion formation following exposure to radiological incidents… Show more Mentor: Bradford Peercy, Ph.D. Thesis title: Modeling the pathogenesis of early-stage atherosclerosis following ionizing radiation exposure: a three-dimensional numerical study using COMSOL • Used a finite element analysis software (COMSOL) to model the three-dimensional pathogenesis of early-stage atherosclerosis following exposure to ionizing radiation • Solved a system of partial differential equations to predict rate of lesion formation following exposure to radiological incidents or radiation therapy • Discovered an increased risk of plaque development with radiation doses of over 2.2 Gray Show less
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Anne Arundel Medical Center
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United States
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Hospitals and Health Care
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700 & Above Employee
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Physician Record Assistant, Oncology and Hematology
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Sep 2015 - May 2016
• Prepared and completed charts for approximately 20-25 internal medicine, oncology, and hematology patients per day • Learned to identify and promptly report critical lab values, weight loss, and radiology reads to the oncologist/hematologist • Observed and accurately documented bone marrow aspirate and biopsy procedures
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Medical Scribe, Emergency Department
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Jun 2012 - Aug 2015
• Assisted provider in properly documenting patient history and review of systems in the electronic medical records • Observed and recorded multiple procedures including laceration care, foreign body removal, incisions and drainages, casting/splinting, intubations, lumbar punctures, and local/general anesthesia • Discharged patients in a timely manner and arranged for outpatient follow-up with the appropriate on-call specialist
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Summer Fellow, Division of Cancer Epidemiology and Genetics, NCI
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Jun 2015 - Sep 2015
Supervisor: Mark Little, D.Phil. • Investigated the potential association between upregulated inflammatory markers and low-dose, occupational radiation exposure • Developed a computational environment that replicated the composition of human blood and the physiology of a human coronary artery Supervisor: Mark Little, D.Phil. • Investigated the potential association between upregulated inflammatory markers and low-dose, occupational radiation exposure • Developed a computational environment that replicated the composition of human blood and the physiology of a human coronary artery
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University of Maryland Baltimore County
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Baltimore, Maryland, United States
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Interdisciplinary Training for Undergraduates in Mathematical and Biological Sciences, NSF-Funded
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Aug 2012 - Dec 2014
Supervisors: Bradford Peercy, Ph.D., Michelle Starz-Gaiano, Ph.D. • Modeled the dynamics of a signaling molecule and its effect on cellular activation patterns in Drosophila melanogaster egg chambers • Computationally assessed border cell arrangements seen in the biological system • Employed a finite difference scheme to approximate the solution to a three-dimensional partial differential equation that accounted for change in concentration of signaling molecule over time Supervisors: Bradford Peercy, Ph.D., Michelle Starz-Gaiano, Ph.D. • Modeled the dynamics of a signaling molecule and its effect on cellular activation patterns in Drosophila melanogaster egg chambers • Computationally assessed border cell arrangements seen in the biological system • Employed a finite difference scheme to approximate the solution to a three-dimensional partial differential equation that accounted for change in concentration of signaling molecule over time
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Summer Fellow, Basic Research Laboratory, NCI
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May 2014 - Aug 2014
Supervisor: Shree Ram Singh, Ph.D. • Dissected and stained Drosophila melanogaster testes with a group of select antibodies • Checked expression of corresponding proteins under a confocal microscope and learned how to take presentation-worthy, fluorescent images • Participated in the characterization of a number of genes involved in germline and somatic stem cell regulation Supervisor: Shree Ram Singh, Ph.D. • Dissected and stained Drosophila melanogaster testes with a group of select antibodies • Checked expression of corresponding proteins under a confocal microscope and learned how to take presentation-worthy, fluorescent images • Participated in the characterization of a number of genes involved in germline and somatic stem cell regulation
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Anne Arundel Community College/Private Tutoring
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Arnold, Maryland, United States
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Mathematics Tutor
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Feb 2008 - Dec 2011
• While still in high school, tutored mathematics from arithmetic and elementary algebra through calculus and differential equations • Coordinated both private and group sessions to supplement student classwork • Assisted students in their development of good study habits and test-taking skills • Attended multiple training workshops to apply towards College Reading and Learning Association certification requirements • While still in high school, tutored mathematics from arithmetic and elementary algebra through calculus and differential equations • Coordinated both private and group sessions to supplement student classwork • Assisted students in their development of good study habits and test-taking skills • Attended multiple training workshops to apply towards College Reading and Learning Association certification requirements
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Education
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University of North Carolina at Chapel Hill
Doctor of Philosophy - PhD, Biostatistics -
University of North Carolina at Chapel Hill
Master of Science - MS, Biostatistics -
University of Maryland Baltimore County
Master of Science - MS, Mathematics -
University of Maryland Baltimore County
Bachelor of Science - BS, Mathematics -
Anne Arundel Community College
Associate of Science - AS, Mathematics