Ann Marie K Weideman, M.S.

Predoctoral Trainee, Cancer Genomics Training Grant (T32) at University of North Carolina at Chapel Hill
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(386) 825-5501
Location
Chapel Hill, North Carolina, United States, US

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Experience

    • United States
    • Higher Education
    • 700 & Above Employee
    • Predoctoral Trainee, Cancer Genomics Training Grant (T32)
      • Aug 2020 - Present

      Supervisors: Joseph Ibrahim, Ph.D., Yuchao Jiang, Ph.D. • Construct Bayesian frameworks to infer tumor phylogenetic history and conduct mutational profiling of tumor subpopulations • Develop methodologies appropriate for the sparsity and stochasticity of single-cell data • Perform variant discovery on the Longleaf Cluster using popular tools for high-throughput sequencing data like Genome Analysis Toolkit (GATK), SAMtools, and Salmon

    • Graduate Research Assistant, Center for AIDS Research (CFAR) Biostatistics Core
      • Aug 2018 - Present

      http://unccfar.org/portfolio/biostatistics/ Supervisor: Michael Hudgens, Ph.D. • Statistically support HIV/AIDS research networks with database management, statistical analysis plans and conduct, power and sample size calculations, safety monitoring committees, interim data monitoring, manuscripts, student mentoring, and exploratory/developmental grant applications • Statistician on phase I/II trials to evaluate the safety and immunogenicity of HIV-1 vaccines or combination… Show more http://unccfar.org/portfolio/biostatistics/ Supervisor: Michael Hudgens, Ph.D. • Statistically support HIV/AIDS research networks with database management, statistical analysis plans and conduct, power and sample size calculations, safety monitoring committees, interim data monitoring, manuscripts, student mentoring, and exploratory/developmental grant applications • Statistician on phase I/II trials to evaluate the safety and immunogenicity of HIV-1 vaccines or combination antiretroviral therapy (ART) • HIV-related work has also entailed adherence studies, rapid ART initiation, CD8 T cell metabolism and inhibition, regulation of HIV latency, dental and prosthodontic care in persons with HIV, and syphilis self-testing

    • Grader, Graduate Biostatistics Courses
      • Aug 2020 - Dec 2021

      Courses graded: Analysis of Categorical Data, BIOS 665 · Fall 2021 Intermediate Statistical Methods, BIOS 662 · Fall 2020

    • Research Services
    • 200 - 300 Employee
    • Post-Baccalaureate Fellow, Neuroimmunological Diseases Section, NIAID
      • Sep 2016 - Sep 2018

      Supervisor: Bibiana Bielekova, M.D. • Statistically supported a team research effort to better understand the pathophysiology of central nervous system injury in order to develop effective therapies and treatment strategies for multiple sclerosis • Employed genetic algorithms, combined with parallel computing on the NIH Biowulf cluster, to develop an MRI disease rating scale • Beta tested a multiple sclerosis test suite (Android platform) and statistically validated outcomes from… Show more Supervisor: Bibiana Bielekova, M.D. • Statistically supported a team research effort to better understand the pathophysiology of central nervous system injury in order to develop effective therapies and treatment strategies for multiple sclerosis • Employed genetic algorithms, combined with parallel computing on the NIH Biowulf cluster, to develop an MRI disease rating scale • Beta tested a multiple sclerosis test suite (Android platform) and statistically validated outcomes from several simple functional tests

    • Summer Fellow, Laboratory of Biological Modeling, NIDDK
      • Jun 2016 - Sep 2016

      Supervisor: Arthur Sherman, Ph.D. • Investigated how a G protein-coupled inwardly-rectifying potassium (GIRK) and transient receptor potential cation (TRP) channel affect electrical oscillations in pancreatic beta-cells • Developed a mathematical model of electrical activity in beta-cells, similar to the Hodgkin-Huxley model used to describe action potentials in neurons • Simulated the effects of glucagon-like peptide-1 (GLP-1) on signal transduction pathways

  • Capitol Technology University
    • Laurel, Maryland, United States
    • Adjunct Faculty in Mathematics & Statistics
      • Aug 2016 - May 2018

      • Independently redesigned curriculum for MA-345, Probability and Statistics for Engineers, to incorporate R programming language and petitioned curriculum change to Probability & Statistics with R for Engineers and Scientists, 1st Edition. • Courses taught: Ordinary Differential Equations, MA-340 · Fall 2016, Spring 2017, Fall 2017, Spring 2018 Introduction to Statistics, MA-128 · Fall 2016, Fall 2017 Probability and Statistics for Engineers, MA-345 · Spring 2017, Spring 2018 • Independently redesigned curriculum for MA-345, Probability and Statistics for Engineers, to incorporate R programming language and petitioned curriculum change to Probability & Statistics with R for Engineers and Scientists, 1st Edition. • Courses taught: Ordinary Differential Equations, MA-340 · Fall 2016, Spring 2017, Fall 2017, Spring 2018 Introduction to Statistics, MA-128 · Fall 2016, Fall 2017 Probability and Statistics for Engineers, MA-345 · Spring 2017, Spring 2018

    • Graduate Student Mathematical Modeling Camp
      • Jun 2016 - Jun 2016

      • Worked with a team of over 85 applied mathematicians, scientists, and junior researchers on mathematical problems in industry • RPI: Utilized two techniques, porosimetry and filtration efficiency, to better understand the properties of an ideal filter • Duke: Contributed to the development of an application that tracks patient asthma and COPD symptoms and recommends a course of action based on symptom severity • Worked with a team of over 85 applied mathematicians, scientists, and junior researchers on mathematical problems in industry • RPI: Utilized two techniques, porosimetry and filtration efficiency, to better understand the properties of an ideal filter • Duke: Contributed to the development of an application that tracks patient asthma and COPD symptoms and recommends a course of action based on symptom severity

  • University of Maryland Baltimore County
    • Baltimore, Maryland, United States
    • Master’s Thesis
      • Sep 2015 - May 2016

      Mentor: Bradford Peercy, Ph.D. Thesis title: Modeling the pathogenesis of early-stage atherosclerosis following ionizing radiation exposure: a three-dimensional numerical study using COMSOL • Used a finite element analysis software (COMSOL) to model the three-dimensional pathogenesis of early-stage atherosclerosis following exposure to ionizing radiation • Solved a system of partial differential equations to predict rate of lesion formation following exposure to radiological incidents… Show more Mentor: Bradford Peercy, Ph.D. Thesis title: Modeling the pathogenesis of early-stage atherosclerosis following ionizing radiation exposure: a three-dimensional numerical study using COMSOL • Used a finite element analysis software (COMSOL) to model the three-dimensional pathogenesis of early-stage atherosclerosis following exposure to ionizing radiation • Solved a system of partial differential equations to predict rate of lesion formation following exposure to radiological incidents or radiation therapy • Discovered an increased risk of plaque development with radiation doses of over 2.2 Gray Show less Mentor: Bradford Peercy, Ph.D. Thesis title: Modeling the pathogenesis of early-stage atherosclerosis following ionizing radiation exposure: a three-dimensional numerical study using COMSOL • Used a finite element analysis software (COMSOL) to model the three-dimensional pathogenesis of early-stage atherosclerosis following exposure to ionizing radiation • Solved a system of partial differential equations to predict rate of lesion formation following exposure to radiological incidents… Show more Mentor: Bradford Peercy, Ph.D. Thesis title: Modeling the pathogenesis of early-stage atherosclerosis following ionizing radiation exposure: a three-dimensional numerical study using COMSOL • Used a finite element analysis software (COMSOL) to model the three-dimensional pathogenesis of early-stage atherosclerosis following exposure to ionizing radiation • Solved a system of partial differential equations to predict rate of lesion formation following exposure to radiological incidents or radiation therapy • Discovered an increased risk of plaque development with radiation doses of over 2.2 Gray Show less

    • United States
    • Hospitals and Health Care
    • 700 & Above Employee
    • Physician Record Assistant, Oncology and Hematology
      • Sep 2015 - May 2016

      • Prepared and completed charts for approximately 20-25 internal medicine, oncology, and hematology patients per day • Learned to identify and promptly report critical lab values, weight loss, and radiology reads to the oncologist/hematologist • Observed and accurately documented bone marrow aspirate and biopsy procedures

    • Medical Scribe, Emergency Department
      • Jun 2012 - Aug 2015

      • Assisted provider in properly documenting patient history and review of systems in the electronic medical records • Observed and recorded multiple procedures including laceration care, foreign body removal, incisions and drainages, casting/splinting, intubations, lumbar punctures, and local/general anesthesia • Discharged patients in a timely manner and arranged for outpatient follow-up with the appropriate on-call specialist

    • Summer Fellow, Division of Cancer Epidemiology and Genetics, NCI
      • Jun 2015 - Sep 2015

      Supervisor: Mark Little, D.Phil. • Investigated the potential association between upregulated inflammatory markers and low-dose, occupational radiation exposure • Developed a computational environment that replicated the composition of human blood and the physiology of a human coronary artery Supervisor: Mark Little, D.Phil. • Investigated the potential association between upregulated inflammatory markers and low-dose, occupational radiation exposure • Developed a computational environment that replicated the composition of human blood and the physiology of a human coronary artery

  • University of Maryland Baltimore County
    • Baltimore, Maryland, United States
    • Interdisciplinary Training for Undergraduates in Mathematical and Biological Sciences, NSF-Funded
      • Aug 2012 - Dec 2014

      Supervisors: Bradford Peercy, Ph.D., Michelle Starz-Gaiano, Ph.D. • Modeled the dynamics of a signaling molecule and its effect on cellular activation patterns in Drosophila melanogaster egg chambers • Computationally assessed border cell arrangements seen in the biological system • Employed a finite difference scheme to approximate the solution to a three-dimensional partial differential equation that accounted for change in concentration of signaling molecule over time Supervisors: Bradford Peercy, Ph.D., Michelle Starz-Gaiano, Ph.D. • Modeled the dynamics of a signaling molecule and its effect on cellular activation patterns in Drosophila melanogaster egg chambers • Computationally assessed border cell arrangements seen in the biological system • Employed a finite difference scheme to approximate the solution to a three-dimensional partial differential equation that accounted for change in concentration of signaling molecule over time

    • Summer Fellow, Basic Research Laboratory, NCI
      • May 2014 - Aug 2014

      Supervisor: Shree Ram Singh, Ph.D. • Dissected and stained Drosophila melanogaster testes with a group of select antibodies • Checked expression of corresponding proteins under a confocal microscope and learned how to take presentation-worthy, fluorescent images • Participated in the characterization of a number of genes involved in germline and somatic stem cell regulation Supervisor: Shree Ram Singh, Ph.D. • Dissected and stained Drosophila melanogaster testes with a group of select antibodies • Checked expression of corresponding proteins under a confocal microscope and learned how to take presentation-worthy, fluorescent images • Participated in the characterization of a number of genes involved in germline and somatic stem cell regulation

    • Mathematics Tutor
      • Feb 2008 - Dec 2011

      • While still in high school, tutored mathematics from arithmetic and elementary algebra through calculus and differential equations • Coordinated both private and group sessions to supplement student classwork • Assisted students in their development of good study habits and test-taking skills • Attended multiple training workshops to apply towards College Reading and Learning Association certification requirements • While still in high school, tutored mathematics from arithmetic and elementary algebra through calculus and differential equations • Coordinated both private and group sessions to supplement student classwork • Assisted students in their development of good study habits and test-taking skills • Attended multiple training workshops to apply towards College Reading and Learning Association certification requirements

Education

  • University of North Carolina at Chapel Hill
    Doctor of Philosophy - PhD, Biostatistics
    2018 - 2024
  • University of North Carolina at Chapel Hill
    Master of Science - MS, Biostatistics
    2018 - 2021
  • University of Maryland Baltimore County
    Master of Science - MS, Mathematics
    2015 - 2016
  • University of Maryland Baltimore County
    Bachelor of Science - BS, Mathematics
    2009 - 2014
  • Anne Arundel Community College
    Associate of Science - AS, Mathematics
    2007 - 2010

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