Experience

Eleven Therapeutics
• United Kingdom
• Research
• 1 - 100 Employee
• Senior Scientist (RNA Technologies)

  • Oct 2022 - Present


University of Toronto

• Canada
• Higher Education
• 700 & Above Employee

• Research Associate

  • Apr 2022 - Aug 2022

  Postdoctoral Research Associate in the lab of Dr. Benjamin J. Blencowe.• Characterizing the structure and function of the human Ribonucleosome.

• Postdoctoral Fellow

  • Sep 2015 - Mar 2022

  Postdoctoral Fellow in the lab of Dr. Benjamin J. Blencowe.1. Performed "Neu-SPAR-Seq" high-throughput genetic screen to identify and characterize novel regulators of neurogenesis-associated alternative splicing.• Utilized a wide range of techniques, including the detailed characterization of alternative protein isoforms, CRISPR/Cas9 editing of mESCs, neural differentiation, isoform-specific iCLIP, AP-MS, RNA-seq, in vitro splicing assays and scRNA-seq.• This work resulted in a co-first author publication in Molecular Cell, and was funded by an EMBO Postdoctoral Fellowship.2. Performed a high-throughput small molecule screen (100K) to identify small molecule modulators of ASD-associated microexon splicing.• Developed novel dual-luciferase reporter assays amenable to high-throughput screening and performed extensive validatory experiments including in vivo rescue of microexon splicing in the cerebral cortex of an ASD mouse model.• This work was funded by a CIHR postdoctoral fellowship. Show less



Newcastle University

• United Kingdom
• Higher Education
• 700 & Above Employee

• Postdoctoral Research Assistant

  • Jan 2015 - Aug 2015

  Postdoctoral Research Assistant in the lab of Dr. David J. Elliott.• Investigated the therapeutic potential of targeting Checkpoint kinase 1 (CHEK1) splice variants in breast cancer.

• Ph.D. Student

  • Sep 2010 - Dec 2014

  Ph.D. in Molecular Genetics in the lab of Dr. David J. Elliott.• Characterized regulatory mechanisms and functions of alternative pre-mRNA splicing in breast cancer.• Utilized a wide range of molecular biology techniques including mammalian cell culture, transcriptome-wide mapping of protein-RNA interactions (iCLIP), RNA-seq, splicing reporter minigene assays, cell growth and proliferation assays, and RNA and protein biochemistry.• This work resulted in 5 publications, including a first author publication in Nature Communications.• Awarded Newcastle University Doctoral Thesis Prize (Medical Genetics). Show less