Amy Mandigo
Senior Scientist at Regeneron- Claim this Profile
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Topline Score
Bio
Experience
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Regeneron
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United States
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Biotechnology
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700 & Above Employee
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Senior Scientist
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Mar 2023 - Present
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Associate Scientist
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Sep 2021 - Mar 2023
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Thomas Jefferson University
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United States
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Higher Education
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700 & Above Employee
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PHD Candidate
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Aug 2014 - Aug 2021
- Identified a new subset of castration-resistance prostate cancer that responds poorly to cytotoxic therapy. - Discovered a novel role for the retinoblastoma tumor suppressor protein (RB) in the regulation of cancer cell metabolism through negative control of the E2F1 transcription factor in advanced castration-resistant prostate cancer. - Elucidated the mechanism of the androgen receptor and E2F1 co-regulation of cancer-related transcription. - Identified a new subset of castration-resistance prostate cancer that responds poorly to cytotoxic therapy. - Discovered a novel role for the retinoblastoma tumor suppressor protein (RB) in the regulation of cancer cell metabolism through negative control of the E2F1 transcription factor in advanced castration-resistant prostate cancer. - Elucidated the mechanism of the androgen receptor and E2F1 co-regulation of cancer-related transcription.
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Marist College
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United States
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Higher Education
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700 & Above Employee
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Information Technology Helpdesk Support
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Dec 2011 - Aug 2014
- Coordinated between customers and several departments within Information Technology regarding computer hardware and software troubleshooting and service requests - Managed and trained new employees in assisting customers, submitting reports, and resolving issues - Developed a training program and manual for all new employees - Coordinated between customers and several departments within Information Technology regarding computer hardware and software troubleshooting and service requests - Managed and trained new employees in assisting customers, submitting reports, and resolving issues - Developed a training program and manual for all new employees
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Education
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Thomas Jefferson University Hospitals
PhD in Biochemistry and Molecular Pharmacology, Cancer Biology -
Marist College
Bachelor of Science (B.S.), Chemistry/Biochemistry